A5001553975- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- Advanced Polymer Synthesis and Characterization
- Polymer Surface Interaction Studies
- Advanced Nanomaterials in Catalysis
- RNA Interference and Gene Delivery
- Immune cells in cancer
- Hydrogels: synthesis, properties, applications
- Graphene and Nanomaterials Applications
- Advanced biosensing and bioanalysis techniques
- Dendrimers and Hyperbranched Polymers
- Cell Adhesion Molecules Research
- Phagocytosis and Immune Regulation
- Bone Tissue Engineering Materials
- Magnetic Properties and Synthesis of Ferrites
- Advanced Drug Delivery Systems
- Electrospun Nanofibers in Biomedical Applications
- Wound Healing and Treatments
- Zebrafish Biomedical Research Applications
- biodegradable polymer synthesis and properties
- Oral microbiology and periodontitis research
- Autophagy in Disease and Therapy
- Magnetic properties of thin films
- Antimicrobial Peptides and Activities
Chongqing University
2016-2025
Chongqing Three Gorges University
2025
Children's Hospital of Fudan University
2022-2025
Kanion Pharmaceutical (China)
2025
Harbin Institute of Technology
2024
Dalian Ocean University
2023
Central South University
2021-2023
Soochow University
2023
Xiangya Hospital Central South University
2021-2023
Northern Jiangsu People's Hospital
2015-2023
Atherosclerosis (AS), the underlying cause of most cardiovascular events, is one common causes human morbidity and mortality worldwide due to lack an efficient strategy for targeted therapy. In this work, we aimed develop ideal biomimetic nanoparticle AS Methods: Based on macrophage "homing" into atherosclerotic lesions cell membrane coating nanotechnology, nanoparticles (MM/RAPNPs) were fabricated with a (MM) surface rapamycin-loaded poly (lactic-co-glycolic acid) copolymer (PLGA) (RAPNPs)....
Cardiovascular disease is the leading cause of mortality worldwide. Atherosclerosis, one most common forms disease, characterized by a gradual formation atherosclerotic plaque, hardening, and narrowing arteries. Nanomaterials can serve as powerful delivery platforms for atherosclerosis treatment. However, their therapeutic efficacy substantially limited in vivo due to nonspecific clearance mononuclear phagocytic system. In order address this limitation, rapamycin (RAP)-loaded poly(lactic-
The efficacy of cardiac regenerative strategies for myocardial infarction (MI) treatment is greatly limited by the microenvironment. combination reactive oxygen species (ROS) scavenging to suppress oxidative stress damage and macrophage polarization M2 phenotype in MI microenvironment can be desirable treatment. Herein, melanin nanoparticles (MNPs)/alginate (Alg) hydrogels composed two marine-derived natural biomaterials, MNPs obtained from cuttlefish ink alginate extracted ocean algae, are...
Nanoparticles (NPs) modified by cell membranes represent an emerging biomimetic platform that can mimic the innate biological functions resulting from various in systems. researchers focus on constructing membrane camouflaged NPs using a wide variety of cells, such as red blood (RBC), macrophages and cancer cells. Cell (CMNPs) inherit composition membranes, including specific receptors, antigens, proteins, for target delivering to tumor, escaping immune clearance, prolonging circulation...
Oral antioxidant nanozymes bring great promise for inflammatory bowel disease (IBD) treatment. To efficiently eliminate reactive oxygen species (ROS), various metal-based have been developed the treatment of IBD but their practical applications are seriously impaired by unstable ROS-eliminating properties and potential metal ion leakage in digestive tract. Here, authors first time propose metal-free melanin (MeNPs) with excellent gastrointestinal stability biocompatibility as a favorable...
With the in-depth and comprehensive study of bacteria their related ecosystems in human body, bacterial-based drug delivery system has become an emerging biomimetic platform that can retain innate biological functions. Benefiting from its good biocompatibility ideal targeting ability as a carrier, Escherichia coli Nissle 1917 (ECN) been focused on treatment strategies inflammatory bowel disease tumor. The advantage bacterial carrier is it express exogenous protein while also acting natural...
Non-invasive localization of lesions and specific targeted therapy are still the main challenges for inflammatory bowel disease (IBD). Ta, as a medical metal element, has been widely used in treatment different diseases because its excellent physicochemical properties but is far from being explored IBD. Here, Ta2 C modified with chondroitin sulfate (CS) (TACS) evaluated highly nanomedicine Specifically, TACS dual targeting CS functions due to IBD lesion-specific positive charges high...
The role of the anti–inflammatory cytokine interleukin–10 (IL–10) was investigated in mouse model liver injury induced by carbon tetrachloride (CCl 4 ). To address endogenous IL–10 production, acute hepatitis CCl C57Bl/6 gene knock out (KO) and wild–type (WT) mice. After challenge, serum levels tumor necrosis factor–alpha (TNF–α) transforming growth factor–beta 1 (TGF–β1) increased were significantly higher KO mice, whereas IL–6 only slightly compared with WT At histological examination,...
Abstract Ulcerative colitis (UC), affecting millions of patients worldwide, is associated with disorders the gut microbiota. Probiotics‐based therapy positively regulating community structure microbiota regarded as an efficient intervention for UC. However, oral probiotics delivery restricted by limited bioactivity, short retention time, complex pathological condition, and single therapeutic efficacy. Here, a bioengineered probiotic decorated multifunctional prodrug coating constructed to...
The increased incidence of inflammatory bowel disease (IBD) has seriously affected the life quality patients. IBD develops due to excessive intestinal epithelial cell (IEC) apoptosis, disrupting gut barrier, colonizing harmful bacteria, and initiating persistent inflammation. current therapeutic approaches that reduce inflammation are limited. Although can be treated significantly by directly preventing IEC achieving this approach remains challenging. Accordingly, authors first develop an...
The escalating prevalence of microplastics and nanoplastics in aquatic environments is a major challenge affecting the behavior reproductive health organisms while posing potential risks to human ecosystems. This review focuses on neurobehavioral changes toxicity MNPs zebrafish their relationships. At same time, caused by were studied, synergistic effects interaction these pollutants with other environmental contaminants explored. In addition, zebrafish, as model organism, provide valuable...