A5100692044- Advanced biosensing and bioanalysis techniques
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- RNA Interference and Gene Delivery
- Biosensors and Analytical Detection
- Immunotherapy and Immune Responses
- Mesenchymal stem cell research
- Immune Cell Function and Interaction
- Advanced Nanomaterials in Catalysis
- Neuroinflammation and Neurodegeneration Mechanisms
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Multiple Sclerosis Research Studies
- Neurological Disease Mechanisms and Treatments
- T-cell and B-cell Immunology
- Cervical Cancer and HPV Research
- Myasthenia Gravis and Thymoma
- DNA and Biological Computing
- Medical Research and Treatments
- Electrochemical Analysis and Applications
- Cancer Mechanisms and Therapy
- Epigenetics and DNA Methylation
- Nanocluster Synthesis and Applications
First Affiliated Hospital of Xinjiang Medical University
2023-2025
Xinjiang Medical University
2023-2025
Blood Center of Zhejiang Province
2025
Central South University
2019-2024
Xiangya Hospital Central South University
2021-2024
Peking University
2020-2024
Center for Disease Control
2024
King University
2024
Inner Mongolia Comprehensive Disease Prevention and Control Center
2024
Jiangnan University
2024
Oral antioxidant nanozymes bring great promise for inflammatory bowel disease (IBD) treatment. To efficiently eliminate reactive oxygen species (ROS), various metal-based have been developed the treatment of IBD but their practical applications are seriously impaired by unstable ROS-eliminating properties and potential metal ion leakage in digestive tract. Here, authors first time propose metal-free melanin (MeNPs) with excellent gastrointestinal stability biocompatibility as a favorable...
Non-invasive localization of lesions and specific targeted therapy are still the main challenges for inflammatory bowel disease (IBD). Ta, as a medical metal element, has been widely used in treatment different diseases because its excellent physicochemical properties but is far from being explored IBD. Here, Ta2 C modified with chondroitin sulfate (CS) (TACS) evaluated highly nanomedicine Specifically, TACS dual targeting CS functions due to IBD lesion-specific positive charges high...
The increased incidence of inflammatory bowel disease (IBD) has seriously affected the life quality patients. IBD develops due to excessive intestinal epithelial cell (IEC) apoptosis, disrupting gut barrier, colonizing harmful bacteria, and initiating persistent inflammation. current therapeutic approaches that reduce inflammation are limited. Although can be treated significantly by directly preventing IEC achieving this approach remains challenging. Accordingly, authors first develop an...
The present study was aimed to investigate whether Gensini score or SYNTAX a valuable tool predict in-stent restenosis (ISR) in coronary artery disease (CAD) patients with drug-eluting stents (DES) implantation. A retrospective case-control and validating cohort were designed. All subjects' information collected from the First Affiliated Hospital of Xinjiang Medical University. total 916 enrolled study, 961 subjects included retrospective-cohort study. In significant differences observed...
The immunoregulatory protein B7-H3, a member of the B7 family, has been confirmed to be highly expressed in colon cancer. However, exact influence B7-H3 on features and antitumor ability γδT cells cancer remains unknown. In present study, we investigated that proportions B7-H3+ were distinctly increased peripheral blood tumor tissues patients. blockade or knockdown promoted proliferation, inhibited cell apoptosis induced expression activation markers (CD25 CD69) Vδ2 T cells. contrast,...
Though experimental evidence shows that human bone marrow-derived mesenchymal stem cells (hBMSCs) are able to suppress T-cell activation and proliferation, the precise mechanisms still not completely understood. Here, we investigated role of negative costimulatory molecule B7-H4 in immunosuppressive effect hBMSCs on activation. We showed expresses abundantly assessed by reverse transcription, immunofluorescence staining, flow cytometric analysis. Further studies demonstrated expressed...
Abstract On the basis of daily data from Japanese 55-year Reanalysis (JRA-55) for extended winters (December–March) 1958/59 to 2014/15, this study examines formation mechanisms and climate impacts subseasonal Scandinavian (SCA) pattern. Results indicate that SCA pattern manifests itself as Rossby wave trains, arising initial height disturbances over North Atlantic propagating into peninsula central Siberia. One type may arise a train is closely coupled an anomalous convective heating dipole...
In this study, we have developed novel fluorescence logic gates for simultaneous analysis of telomerase activity and miRNA. An imperfectly complementary duplex is assembled which can be destroyed by catalyzed extension or miRNA mediated strand displacement. The released single-stranded DNA further initiates the subsequent hybridization chain reaction. output response OR gate originates from fuel strand-templated silver nanoclusters (AgNCs). On other hand, a three-way junction constructed AND...
The primary impediment to the success of immunotherapy lies in immune evasion orchestrated by tumors, contributing suboptimal overall response rates observed. Despite this recognition, intricacies underlying mechanisms remain incompletely understood. Through preliminary detection clinical patient tissues, we have found that ALDH1A1 was a key gene for prognosis cancer patients and tumor glycolysis. In vitro experiments formation nude mice suggested targeting could inhibit growth. further...
Endometrial cancer (EC) is a gynecological malignant tumor characterized by high incidence. EC occurrence and development are regulated numerous molecules signal pathways. There need to explore key regulatory identify potential therapeutic targets reduce the incidence of EC. Treatment targeting single molecule poor efficacy owing resistance significant side effects. The current study explored candidates in integrating bioinformatics analysis vivo vitro experimental validation circumvent...
Endoscopic retrograde cholangiopancreatography (ERCP) is an established treatment for common bile duct (CBD) stones. Post- ERCP cholecystitis (PEC) a known complication of such procedure and there are no effective models clinical applicable tools PEC prediction.A random forest (RF) machine learning model was developed to predict PEC. Eligible patients at The First Hospital Lanzhou University in China with stones gallbladders in-situ were enrolled from 2010 2019. Logistic regression analysis...
Purpose: To investigate the expression and distribution of Rh phenotypes (C, c, D, E, e) among voluntary blood donors in a specific region East China, to establish regional phenotype database, enhance precision efficacy clinical transfusions. Patients Methods: A total 28979 samples were collected from at central station China between May 2023 December 2023. An automated type analyzer was used determine phenotypes, which then applied clinically for ABO type-matching Results: Analysis 28672...
Deep neural networks (DNNs) such as convolutional (CNNs) for visual tasks, recurrent (RNNs) sequence data, and transformer models rich linguistic or multimodal achieved unprecedented performance on a wide range of tasks. The impressive modern DNNs is partially attributed to their sheer scale. latest deep learning have tens hundreds millions parameters which makes the inference processes resource-intensive. high computational complexity these prevents deployment resource-limited devices...
Abstract Ovarian cancer (OC) is the most lethal gynaecological malignancy, characterized by high recurrence and mortality. However, mechanisms of its pathogenesis remain largely unknown, hindering investigation functional roles. This study sought to identify key hub genes that may serve as biomarkers correlated with prognosis. Here, we conduct an integrated analysis using weighted gene co‐expression network (WGCNA) explore clinically significant sets candidate associated OC clinical...
Herein, a highly sensitive electrochemical genosensor is proposed by the construction of an innovative DNA walking machine. Generally, number tetrahedral (TDNA)-supported tracks and walkers are comodified on electrode surface. inhibited in absence target DNA. After interaction between walker strand DNA, single-stranded primer sequence could be released, which initiates subsequent rolling circle amplification (RCA). The generated long product contains multiple DNAzyme cores, facilitate...
Artificial intelligence (AI) discrimination models using single radioactive variables in recognition algorithms of lung nodules cannot predict cancer accurately. Hence, we developed a clinical model that combines AI with blood test to cancer.Between 2018 and 2021, 584 individuals (358 patients 226 other than as control) were enrolled prospectively. Machine learning including lasso regression random forest (RF) used select from data, Logistic analysis was reconfirm the features build nomogram...
Background: The tumor microenvironment and immunity have become the focus of research on diagnosis treatment. Lymphocyte activation gene-3 (LAG-3, CD223) is a newly discovered immunosuppressive receptor that abnormally expressed in various microenvironments plays an important role as immune checkpoint response. Objective: We developed novel enzyme-linked immunosorbent assay kit, examined levels soluble LAG-3 (sLAG-3) serum patients with cervical cancer, identified new biomarkers for cancer...