A5100339039- Influenza Virus Research Studies
- Respiratory viral infections research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Viral gastroenteritis research and epidemiology
- Gut microbiota and health
- Hepatitis C virus research
- COVID-19 epidemiological studies
- Hepatitis Viruses Studies and Epidemiology
- Liver Disease and Transplantation
- Viral Infections and Vectors
- COVID-19 Clinical Research Studies
- Metabolomics and Mass Spectrometry Studies
- Virology and Viral Diseases
- Sepsis Diagnosis and Treatment
- COVID-19 diagnosis using AI
- Animal Disease Management and Epidemiology
- Probiotics and Fermented Foods
- Thermal Regulation in Medicine
- Cancer, Lipids, and Metabolism
- Global Cancer Incidence and Screening
- vaccines and immunoinformatics approaches
- Viral-associated cancers and disorders
- Lipoproteins and Cardiovascular Health
- Infection Control and Ventilation
Yangzhou University
2022-2025
Shandong Agricultural University
2025
Chinese PLA General Hospital
2024
Chinese People's Liberation Army
2024
Daping Hospital
2024
Army Medical University
2024
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2018-2023
Zhejiang University
2018-2023
Kunming Medical University
2023
First Affiliated Hospital Zhejiang University
2020-2022
This study aimed to investigate region-specific epidemiologic characteristics of influenza and transmission zones (ITZs).Weekly surveillance data 156 countries from 1996 2021 were obtained using FluNet. Joinpoint regression was used describe global virus trends, clustering analyses classify the ITZs.The median average positive rate for total 16.19% (interquartile range: 11.62-25.70%). Overall, three major subtypes (influenza H1, H3, B viruses) showed alternating epidemics. Notably,...
As a prevalent agent in cats, feline herpesvirus 1 (FHV-1) infection contributes to respiratory disease and acute chronic conjunctivitis. FHV-1 can successfully evade the host innate immune response persist for lifetime of cat. Several mechanisms evasion by human herpesviruses have been elucidated, but mechanism remains unknown. In this study, we screened open reading frames (ORFs) responsible inhibiting type I interferon (IFN) pathway with an IFN-β promoter reporter analysis mRNA levels HEK...
Objective To evaluate the trends in disease burden and epidemiological features of liver cancer China while identifying potential strategies to lower burden. Design Observational study based on Global Burden Diseases. Participants Data were publicly available de-identified individuals not involved. Measurement methods measure burden, we extracted data from Health Exchange using metrics prevalence, incidence, mortality disability-adjusted life years (DALYs). Joinpoint negative binomial...
Introduction As an important pathogen causing diarrheal diseases, the burden and change in death rate of norovirus-associated diseases (NADs) globally are still unknown. Methods Based on global disease data from 1990 to 2019, we analyzed age-standardized (ASDR) NADs by age, region, country, Socio-Demographic Index (SDI) level. The discrete Poisson model was applied analysis NADs' spatiotemporal aggregation, Joinpoint regression analyze trend over 30 years, a generalized linear identify risk...
Abstract Acute Kidney Injury (AKI) is a common complication encountered among hospitalized patients, imposing significantly increased cost, morbidity, and mortality. Early prediction of AKI has profound clinical implications because currently no treatment exists for once it develops. Feature selection (FS) an essential process building accurate interpretable models, but to our best knowledge study investigated the robustness applicability such AKI. In this study, we compared eight...
Abstract Background Chronic hepatitis B virus (HBV) infection is characterized by the presence of dysfunctional exhausted CD8 + T cells that hamper viral control. We investigated phenotypic heterogeneity in HBV carriers. Methods enrolled 31 carriers and 23 healthy controls (HCs) our study. Peripheral blood mononuclear (PBMCs) were isolated, flow cytometry was used to determine distribution cell subsets. Expression cytokines such as TNF-α IFN-γ detected quantitative reverse transcription–PCR,...
Patrinia scabiosaefolia L. (P. scabiosaefolia), a traditional food and medicinal plant, is used to treat internal inflammation. This study investigated the mechanisms by which P. improves ulcerative colitis (UC) via combined UHPLC-OE-MS/MS, network pharmacology, molecular docking, animal experiments. A total of 72 compounds were detected in extraction, with 15 key components (ranking degree value) selected for further analysis. GO enrichment analysis suggested that PS may alleviate...
ABSTRACT This study demonstrates the antioxidative stress potential of Shanyao–Fuling–Yiyiren (SFY) decoction—a Chinese polyherbal formulation derived from Si Fang decoction—by establishing a systematic framework that integrates network pharmacology, molecular docking, in vitro synergy assays, cellular experiments, and 3D printing. Despite its long traditional use, mechanisms underlying effects remain unclear, formulations are based more on empirical methods than design. To fill this gap,...
Previous studies have reported that temperature is the main meteorological factor associated with influenza activity. This study used generalized additive models (GAMs) to explore relationship between and activity in China. From national perspective, average (AT) had an approximately negative linear correlation incidence of influenza, as well a positive rate H1N1 virus (A/H1N1). Every degree monthly AT rose, cases decreased by 2.49% (95%CI: 1.24%-3.72%). The risk reached peak at -5.35 °C RRs...
Abstract Purpose This study aimed to investigate the prevalence and risk factors for myopia high among Han Uyghur students in Xinjiang, China. Methods cross‐sectional with a multistage, stratified cluster sampling method was completed Visual acuity noncycloplegic refraction were measured. The crude sex‐ age‐adjusted of compared. Multivariate logistic regression analyses applied identify associated myopia. Results In total, 84,033 participants included final analysis, comprising 64,110 19,923...
Abstract The colonization ability of Limosilactobacillus fermentum DALI02 and the promoting effect fermented prebiotics have been studied. This study aims to evaluate systemic immunomodulatory effects + Prebiotics on cyclophosphamide‐induced immunosuppressed rats. We found that Prebiotics, especially exhibited significant restorative immunocompromised state in rats ( p < .05). Specifically, both them promoted recovery body weight immune organ function, enhanced proliferative capacity...
A severe seasonal influenza epidemic was observed during 2017–2018 in China, prompting questions on clinical characteristics and outcomes of cases with influenza. We retrospectively collected data laboratory-confirmed hospitalized patients (severe to critical) Jan-2011 Feb-2018 from five hospitals, followed by a systematic analysis 2017 2018 (n = 289) all previous epidemics 2011–2017 169). In-hospital fatality over 5-folds higher the (p < 0.01) which 19 died (6.6%), whereas only 2...
Zeolitic imidazolate framework-8 (ZIF-8)/semiconductor nanocomposites were synthesized by a simple method. The composed of the in situ grown ZIF-8 and supported ZnIn-layered double oxides (ZnIn-LDOs), which ZnIn-LDOs used as Zn2+ source to form ZIF-8. formed calcining microhydrothermally hydroxide precursor. effect amount on morphology photocatalytic activity was studied. aggregation shape dodecahedron flower. ZI-1-ZIF-8 exhibited excellent photodegradation activity, degradation rate...
Liver cirrhosis is one of the leading causes decreased life expectancy worldwide. However, molecular mechanisms underlying liver remain unclear. In this study, we performed a comprehensive analysis using transcriptome and metabolome sequencing to explore genes, pathways, interactions associated with cirrhosis.