A5032266715- Gastrointestinal motility and disorders
- Gut microbiota and health
- Diet and metabolism studies
- Viral Infections and Immunology Research
- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Pituitary Gland Disorders and Treatments
- Liver Disease Diagnosis and Treatment
- Folate and B Vitamins Research
- Adipose Tissue and Metabolism
- Retinal Diseases and Treatments
- Viral gastroenteritis research and epidemiology
- HIV, Drug Use, Sexual Risk
- HIV/AIDS Research and Interventions
- Thyroid Disorders and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Genetic Syndromes and Imprinting
- Asthma and respiratory diseases
- Congenital gastrointestinal and neural anomalies
- Peroxisome Proliferator-Activated Receptors
- Growth Hormone and Insulin-like Growth Factors
- Systemic Lupus Erythematosus Research
- Ovarian function and disorders
- Epigenetics and DNA Methylation
- Functional Brain Connectivity Studies
Sun Yat-sen University
2019-2025
The First Affiliated Hospital, Sun Yat-sen University
2019-2025
Sichuan University
2024
West China Hospital of Sichuan University
2024
North Sichuan Medical University
2024
Nanchong Central Hospital
2024
Affiliated Hospital of Southwest Medical University
2021-2023
Versus Arthritis
2023
Weatherford College
2023
Beijing Luhe Hospital Affiliated to Capital Medical University
2022
An increased prevalence of impaired glucose homeostasis (IGH) and diabetes mellitus is reported in monosomy X, or Turner syndrome (TS). To determine whether IGH an intrinsic feature this syndrome, independent obesity hypogonadism, we compared results a standard oral challenge age- body mass index-matched women with TS karyotypically normal premature ovarian failure (POF). Fasting levels were both groups, but values after higher [2-h glucose, 135 +/- 36 mg/dl (7.5 2.0 mmol/liter) 97 18 (5.4...
Abstract Background Short-chain fatty acids (SCFAs) alteration have been reported in irritable bowel syndrome (IBS), but the results are conflicting. Our study aims to explore of SCFAs patients with diarrhea-predominant IBS (IBS-D) and their potential role occurrence development IBS. Methods We recruited IBS-D defined by Rome IV criteria age-and-gender matched healthy controls (HCs). A headspace solid-phase microextraction gas chromatography–mass spectrometric (HS-SPME-GC-MS) method was...
Serum pigment epithelium-derived factor (PEDF) is highly expressed in adipose tissue and plays an important role insulin resistance (IR). However, there are no data on serum PEDF levels their relationship with IR polycystic ovary syndrome (PCOS) women.To quantitate examine women PCOS.Ninety-six PCOS 63 healthy age-matched controls were recruited. Ninety-six 20 underwent hyperinsulinemic-euglycemic clamp to assess sensitivity, which was as M value. also estimated by homeostasis model...
Abstract To investigate the effects of ketamine on glucose uptake and transporter (GLUT) expression in depressive-like mice. After HA1800 cells were treated with ketamine, 2-[N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)Amino]-2-Deoxyglucose (2-NBDG) was added to test uptake, production lactate, levels GLUT, ERK1/2, AKT, AMPK. Adult female C57BL/6 mice subjected chronic unpredictable mild stress (CUMS), 27 CUMS randomly divided into depression, (i.p.10 mg/kg), FR180204 (ERK1/2 inhibitor, i.p.100...
Gut microbiota plays a crucial role in the pathogenesis and treatment of functional constipation (FC). The aim this study was to explore therapeutic effects Bifidobacterium Lactobacillus triple viable on slow transit (STC). Patients with STC who met Rome IV criteria received viable. Gastrointestinal time (GITT) constipation-related symptoms were assessed before after receiving Additionally, rat model induced by loperamide treated evaluate whether could improve rats possible mechanisms...
The present study aims to evaluate the effects of basic periodontal disease therapy on general condition and serum inflammatory indicators patients with rheumatoid arthritis (RA) combined chronic periodontitis (CP).Forty RA were enrolled in and, based results an oral examination line 2018 diagnostic criteria, they divided into a group CP (the + group) without group). Twenty-nine who attended department our hospital recruited as only group), 20 volunteers any systemic or healthy control H...
Structural changes in the gut microbiota are closely related to development of functional constipation, and regulating can improve constipation. Rifaximin is a poorly absorbed antibiotic beneficial for microbiota, but few studies have reported its effects on The purpose this study was investigate effect rifaximin loperamide-induced constipation SD rats. results showed that improved by increasing serum 5-HT, SP, mRNA expression AQP3, AQP8, reducing TLR2 TLR4. In addition, could regulate...
Abstract Background Gut microbiota alterations including small intestinal bacterial overgrowth (SIBO) might play a role in pathogenesis of irritable bowel syndrome (IBS). Rifaximin could effectively and safely improve IBS symptoms. The aim this study was to investigate the effect rifaximin on Gastrointestinal (GI) symptoms, quality life (QOL) SIBO eradication Chinese IBS-D patients. Methods This included 78 patients defined by Rome IV criteria. Patients received 400 mg twice daily for 2...
Abstract Purpose This study aimed to investigate the prevalence and risk factors for myopia high among Han Uyghur students in Xinjiang, China. Methods cross‐sectional with a multistage, stratified cluster sampling method was completed Visual acuity noncycloplegic refraction were measured. The crude sex‐ age‐adjusted of compared. Multivariate logistic regression analyses applied identify associated myopia. Results In total, 84,033 participants included final analysis, comprising 64,110 19,923...
Abstract Objective Gut microbiota might play a crucial role in the pathogenesis of irritable bowel syndrome (IBS), and probiotics supplement may be an effective treatment option. This study aims to explore therapeutic effects Golden bifid on diarrhea-predominant IBS (IBS-D). Methods Twenty-one consecutive IBS-D patients were recruited based Rome IV criteria. All took 2000 mg triple daily for 4 weeks. Gastrointestinal (GI) symptoms, psychological small intestine bacterial overgrowth (SIBO)...
The gut microbiota is involved in the pathogenesis of diarrhea-predominant irritable bowel syndrome (IBS-D), but few studies have focused on role virome IBS-D. We aimed to explore characteristics patients with IBS-D, its interactions bacteria and metabolites, associations between multiomics profiles symptoms. This study enrolled twelve IBS-D eight healthy controls (HCs). stool samples were subjected metavirome sequencing, 16S rRNA gene untargeted metabolomic analysis. participants completed...
Background Mild cognitive impairment (MCI) is the intermediate stage of changes between normal aging and dementia. KLOTH an age-related gene that may contribute to risk MCI. The aim our study was explore association KLOTHO promoter methylation MCI in Xinjiang Uygur Han populations. Methods DNA assay performed using bisulphite pyrosequencing technology among 96 (48 48 controls) Chinese individuals from province China. Results We found significant (CpG1: p = 3.77E-06; CpG2: 1.91E-07; CpG3:...
We investigated type II deiodinase (DIO 2 ) polymorphisms and serum thyroid hormone levels in subjects with mild cognitive impairment (MCI) a Uygur population.We studied the DIO Thr92Ala (rs225014) ORFa-Gly3Asp (rs12885300) of 129 unrelated MCI cases 131 matched controls.All were genotyped using SNaPshot SNP genotyping assays.Serum measured by radioimmunoassay.Levels triiodothyronine thyroxine group significantly lower than those control group.Genotype allele frequencies gene between groups...
Pigment epithelium-derived factor (PEDF) plays an important role in insulin resistance (IR). The study aims to investigate the effect of rosiglitazone, sensitizer, on PEDF production and release both vivo vitro. Male SD rats were divided into normal control group, high-fat rosiglitazone group. Hyperinsulinemic euglycemic clamp was performed evaluate sensitivity. IR models 3T3-L1 adipocytes HepG2 cells established by hyperinsulinemic method. Glucose uptake examined validate adipocytes,...
// Palida Abulizi 1 , Xiao-Hui Zhou Kabinuer Keyimu Mei Luo and Feng-Qing Jin No1 Cadre Wards Medicine, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830054, China Correspondence to: Zhou, email: zhouxiaohpd@163.com Keywords: mild cognitive impairment, Klotho gene, uygur nationality, Han nationality Received: November 02, 2016 Accepted: July 18, 2017 Published: September 06, ABSTRACT secretive protein is an anti-aging regulatory hormone that plays a...
To explore models to improve HIV testing, linkage care and treatment among men who have sex with (MSM) in cooperation community-based organizations (CBOs) China.We introduced a new model for testing services targeting MSM six cities 2013.These provision of rapid by CBO staff streamlined processes screening, confirmation initial reactive screening results, diagnosed people. We monitored attrition along each step the continuum from compared program performance between 2012 2013. According...
Abstract Aims The aim of this study was to explore the clinical characteristics and risk factors for hypersensitivity reactions induced by antituberculosis drugs. Methods A retrospective analysis conducted on medical records patients with active tuberculosis (TB) treated in TB ward at West China Hospital, Sichuan University, from November 2010 April 2020. Results Out 7106 tuberculosis, 205 experienced drugs; incidence 2.9%. predominant manifestation a rash, observed 57.1% (117/205) these...