A5103117904- Hormonal Regulation and Hypertension
- Adrenal and Paraganglionic Tumors
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Adrenal Hormones and Disorders
- Ovarian function and disorders
- Metabolism, Diabetes, and Cancer
- Bone Metabolism and Diseases
- Adipose Tissue and Metabolism
- Chronic Kidney Disease and Diabetes
- Bariatric Surgery and Outcomes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Blood Pressure and Hypertension Studies
- Muscle and Compartmental Disorders
- Systemic Lupus Erythematosus Research
- Natural Antidiabetic Agents Studies
- Atherosclerosis and Cardiovascular Diseases
- HIV-related health complications and treatments
- Birth, Development, and Health
- Gout, Hyperuricemia, Uric Acid
- Estrogen and related hormone effects
- Alcohol Consumption and Health Effects
- Cannabis and Cannabinoid Research
- Osteoarthritis Treatment and Mechanisms
- Effects and risks of endocrine disrupting chemicals
- Retinal Diseases and Treatments
The Affiliated Yongchuan Hospital of Chongqing Medical University
2016-2025
Chongqing Medical University
2016-2025
Second Affiliated Hospital of Nanchang University
2018
Nanchang University
2018
With the widespread use of advanced imaging technology, adrenal tumors are increasingly being identified.To investigate prevalence and characteristics in an unselected screening population China.Cross-sectional study. (ClinicalTrials.gov: NCT04682938).A health examination center China.Adults having annual checkup were invited to be screened for by computed tomography.The participants with had further evaluation malignancy risk function.A total 25 356 screened, 351 whom found have tumors, a...
Aim . This retrospective study is aimed at investigating whether aldosterone-renin ratio (ARR) cutoffs calculated by the plasma aldosterone concentration (PAC)/plasma renin (PRC) should be set differently in patients of different ages. Methods 521 hypertensive were screened for primary aldosteronism (PA) PAC/PRC. 174 diagnosed with PA and 311 essential hypertension (EH) included final analysis. Subjects subdivided into four age groups: <40, 40–49, 50–59, ≥60 years old. Results The...
Accumulating evidence suggests that bisphenol A (BPA) exposure is associated with nonalcoholic fatty liver disease. Disruption of autophagy causes lipid accumulation in hepatocytes. Whether and how BPA regulates remains to be explored. We investigated the effect on hepatocytes examined influence BPA-regulated hepatic accumulation. Male CD1 mice were treated for 8 weeks, followed by histological biochemical evaluation lipids autophagy. Also, effects primary HepG2 cells. Lipid content cells...
Abstract Context The Endocrine Society Guidelines for the diagnosis of primary aldosteronism (PA) suggest that confirmatory tests (CFT) are not required when following criteria met: plasma aldosterone concentration (PAC) is &gt;20 ng/dL, renin below detection levels, and hypokalemia present. evidence applicability guideline limited. Objective To develop validate optimized sparing CFT in PA. Design Setting were developed a Chinese cohort using captopril challenge test, verified by saline...
Serum pigment epithelium-derived factor (PEDF) is highly expressed in adipose tissue and plays an important role insulin resistance (IR). However, there are no data on serum PEDF levels their relationship with IR polycystic ovary syndrome (PCOS) women.To quantitate examine women PCOS.Ninety-six PCOS 63 healthy age-matched controls were recruited. Ninety-six 20 underwent hyperinsulinemic-euglycemic clamp to assess sensitivity, which was as M value. also estimated by homeostasis model...
Abstract Context More than half of patients diagnosed with unilateral primary aldosteronism (UPA) suffer from persisting hypertension after adrenalectomy. Objective The objective this work is to develop and validate a nomogram-based preoperative score (NBPS) predict clinical outcomes adrenalectomy for UPA. Design Setting NBPS was developed in an Asian cohort by incorporating predictors independently associated remission UPA validated Caucasian cohort. Participants comprised achieving...
Background While both renin-dependent and renin-independent aldosterone secretion contribute to aldosteronism, their relative associations with cardiovascular disease (CVD) risk has not been investigated. Methods Results A total of 2909 participants from the FOS (Framingham Offspring Study) baseline, serum concentration, plasma renin concentration who attended sixth examination cycle were followed up until 2014 free CVD included. We further recruited 2612 hypertensive CONPASS (Chongqing...
Diabetes-associated bone complications lead to fragile mechanical strength and osteoporosis, aggravating the disease burden of patients. Advanced evidence shows that chronic hyperglycemia metabolic intermediates, such as inflammatory factor, reactive oxygen species (ROS), advanced glycation end products (AGEs), are regarded dominant hazardous factors complications, whereas pathophysiological mechanisms complex controversial. By establishing a diabetic Sprague-Dawley (SD) rat model loss cell...
Objective . Pigment epithelium-derived factor (PEDF) plays an important role in obesity-induced insulin resistance (IR). The study aims to investigate the effect of metformin, a widely used agent improve IR, on PEDF production both vivo and vitro. Methods SD rats were divided into normal control group, high fat group (HF group), metformin (MET group). Hyperinsulinemic euglycemic clamp was performed evaluate sensitivity. IR models 3T3-L1 HepG2 cells established then treated with inhibitor AMP...
Aldosterone-producing adenoma (APA) is a benign adrenal tumor with autonomous aldosterone production which causes hypertension and excess cardiovascular risk. Protein phosphorylation regulates secretion from cortical cells, but how signaling networks are remodeled in APA remains unknown.We performed an integrated proteomic phosphoproteomic profiling of 15 10 matched nonfunctioning adrenocortical tumors (NFAT) based on the 4-dimensional label-free technique. We further validated our main...
Objective To study the association of transcription factor 7-like 2(TCF7L2)polymorphisms with tvpe 2 diabetes mellitus in Chinese Han population. Methods Two polymorphisms (rs7903146 and rs12255372)of TCF7L2 gene were genotyped 446 patients type mellitus(T2DM group)and 303 normal subiects (NC group) by PCR-restriction fragment length polymorphism(PCR-RFLP).Waist circumference.body mass index,plasma glucose,serum insulin,lipid profiles,high-sensitivity C-reactive protein non-esterified fatty...
Objectives Aldosterone-to-renin ratio (ARR) based screening is the first step in diagnosis of primary aldosteronism (PA). However, guideline-recommended ARR cutoff covers a wide range, from equivalent 1.3 to 4.9 ng·dl−1/mIU∙l−1. We aimed optimize for PA on risk cardiovascular diseases (CVD).