A5074886510- Circular RNAs in diseases
- MicroRNA in disease regulation
- Urologic and reproductive health conditions
- Sperm and Testicular Function
- Renal and related cancers
- Glutathione Transferases and Polymorphisms
- Listeria monocytogenes in Food Safety
- Identification and Quantification in Food
- Insect and Pesticide Research
- Plant Molecular Biology Research
- PARP inhibition in cancer therapy
- Plant Reproductive Biology
- Cardiac electrophysiology and arrhythmias
- Microbial Metabolism and Applications
- Protein Interaction Studies and Fluorescence Analysis
- Pulmonary Hypertension Research and Treatments
- Genomics, phytochemicals, and oxidative stress
- Insect Resistance and Genetics
- PI3K/AKT/mTOR signaling in cancer
- Plant tissue culture and regeneration
- Cardiac Fibrosis and Remodeling
- Hormonal and reproductive studies
- Plant Gene Expression Analysis
- Salmonella and Campylobacter epidemiology
- RNA Interference and Gene Delivery
Nanjing Medical University
2013-2024
Shanghai Jiao Tong University
2018-2024
Shanghai First People's Hospital
2018-2024
East China University of Science and Technology
2009-2022
Shenzhen Nanshan Center for Chronic Disease Control
2021
Yibin University
2021
Jiangsu Province Hospital
2013-2015
University of Idaho
2005-2012
Yangzhou University
2005
Background/Aims: Percutaneous coronary intervention reduces acute myocardial infarction (MI)-induced mortality to a great extent, but effective treatments for MI-induced cardiac fibrosis and heart failure are still lacking. MicroRNAs (miRNAs) play variety of roles in cells have thus been investigated extensively. MicroRNA-223 (miR-223) expression has reported be altered post-MI humans; however, the miR-223 MI remain unknown. Our study aimed elucidate fibrosis. Methods: Cultured fibroblasts...
Overactivation of β-adrenergic receptor (β-AR) can improve cardiac function temporarily but promotes the development and mortality heart failure (HF) in long run.CircRNA, a member noncoding RNAs, tolerate digestion exonuclease be chronic stimulator to cell.But relationship circRNA with HF remains puzzle needs explored.Here, we found that circ-HIPK3 affected concentration Ca 2+ cytoplasm by miR-17-3p through ADCY6 (Adenylate cyclase type 6).The increase caused was ameliorated overexpression...
Mammalian nucleostemin (NS) is preferentially expressed in stem cells and acts to promote cell cycle progression. In plants, activities have be terminated during flower development, this process requires the activation of AGAMOUS (AG) gene expression. Here, a nucleostemin-like 1 gene, NSN1, shown required for development Arabidopsis. The NSN1 mRNA was found inflorescence meristem floral primordia, its protein localized nucleoli. Both heterozygous homozygous plants developed defective flowers...
Nuclear auto-antigenic sperm protein (NASP), initially described as a highly auto-immunogenic testis and sperm-specific protein, is histone chaperone that proved to present in all dividing cells. NASP has two splice variants: testicular (tNASP) somatic form of (sNASP). Only cancer, germ, transformed, embryonic cells have high level expression the tNASP. Up now, little been known about tNASP renal cell carcinoma (RCC). In study, molecular mechanism RCC was explored. The 16 paired human...
Myocardial ischemia–reperfusion injury (MIRI), characterized by post-ischemic cardiomyocytes death and reperfusion myocardial damage, is a lethal yet unresolved complication in the treatment of acute infarction (AMI). Previous studies have demonstrated that poly(ADP-ribose) polymerase-1 (PARP1) participates progression various cardiovascular diseases, reports proved PARP1 can be therapeutic target these but whether it plays role MIRI still unknown. Therefore, this study, we aimed to explore...
Abstract A limited delivery of oxygen and metabolic substrate to the heart caused by myocardial infarction (MI) impairs cardiac function, often results in failure. Here, we identified a circRNA (circ-SNRK) from SNRK (sucrose nonfermenting 1-related kinase, which can increase mitochondrial efficiency) cardiomyocytes (CMs). Circ-SNRK sponge miR-33 turn improved ATP synthesis via SNRK, proving existence circ-SNRK - axis. Furthermore, found that protein NOVA1 (NOVA alternative splicing regulator...
Postischemic myocardial fibrosis is a factor for the development of cardiac dysfunction and malignant arrhythmias, no effective therapy currently available. Circular RNAs are emerging as important epigenetic players in various biological functions; however, their roles unknown. With use rat model postischemic fibrosis, we identified an increase circHNRNPH1 ischemic myocardium after infarction, particularly fibroblasts. In fibroblasts, was responsive to transforming growth β1 (TGF-β1),...
The expansion of weed infestation has increased the demand on new herbicides. A series novel galactosyl moiety-conjugated furylchalcones was facilely synthesized in which furyl group (A ring) combined with substituted benzene (B ring), and a moiety introduced. All these were predicted to be phloem-mobile. Most significantly promoted early seedling growth sorghum barnyardgrass under dark conditions, but all them revealed considerable anti-growth ability illuminated pot plants; especially,...
The loss of cardiomyocytes (CMs) after myocardial infarction (MI) is widely acknowledged to initiate the development heart failure (HF). Herein, we found that circCDYL2 (583 nt) derived from chromodomain Y-like 2 (Cdyl2) significantly upregulated in vitro (oxygen-glucose deprivation (OGD)-treated CMs) and vivo (failing post-MI) can be translated into a polypeptide termed Cdyl2-60aa (~7 kDa) presence internal ribosomal entry sites (IRES). Downregulation decreased OGD-treated CMs or infarcted...
The incidence of renal cell carcinoma (RCC) has been steadily rising each year. There are currently few recognized biomarkers for the diagnosis and prognosis RCC. We investigated semenogelin I (Sg I) expression its clinical significance in patients with levels Sg protein were measured by qPCR Western blotting, respectively. Immunohistochemistry was used to investigate RCC normal tissue from 53 patients. Kaplan–Meier method log-rank test evaluate data. By qRCR (p < 0.01) blot, level benign...
The hope is that photoactive compounds acting as potential insecticides will have reduced environmental risk, but not necessarily the case. In an attempt to elucidate risk by which photoactivated α-terthienyl (α-T) affects human health, effects of exposure 293 cells and insect Tn-5B1-4 α-T at certain doses were characterized. Photoactivated exhibited dose dependence toxicity time kinetics phototoxic activation on growth (EC50 = 6.23 μg/mL) 3.36 μg/mL). appeared be anchorage-independent,...
ObjectiveEpididymal protease inhibitor (Eppin) was located on the surface of spermatozoa and modulates liquefaction human semen. Here, we identify correlative protein partner Eppin to explore molecular mechanism Methods(1) Human seminal vesicle proteins were transferred membrane by Western blotting separated 2-D electrophoresis incubated in recombinant Eppin. The identified Mass Spectrometry (MS) (2). used determine relation rEppin rFibronectin(Fn); (3) Co-localization detected using...
Using the phenylpyrazole insecticide, fipronil for selection in laboratory, a resistant Wenzhou strain of rice stem borer, Chilo suppressalis (Walker) (Lepidoptera: Crambidae) had an LD50 at least 45.3 times greater than susceptible Anhui strain. The realized heritability (h2) 0.213 showed that tolerant phenotype was moderately heritable and potential to develop higher tolerance fipronil. Piperonyl butoxide decreased effects on mortality larvae with 0.27-0.44 synergistic rates, but increased...
Abstract Background: Pulmonary arterial hypertension (PAH) is characterized by excessive proliferation of small pulmonary vascular smooth muscle cells (PASMCs), endothelial dysfunction, and extracellular matrix remodeling. G protein-coupled receptor kinase 2 (GRK2) plays an important role in the maintenance tone blood flow. However, GRK2 pathogenesis PAH unknown. Methods: levels were detected lung tissues from healthy people patients. C57BL/6 mice, cell-specific Grk2 -knockout mice ( Δ SM22...
Meta-analysis Polymorphism Studies of the relationship between male infertility and CYP1A1 polymorphisms are inconclusive. To drive a more precise estimation, we performed meta-analysis based on 1,060 cases 1,225 controls from 7 published case-control studies. PubMed CNKI literature search were conducted to identify all eligible studies investigating such relationship. Crude odds ratios (ORs) with 95% confidence intervals (CIs) used assess strength association in additive model, dominant...
Background Glutathione S-transferases (GSTs) are a family of multifunctional enzymes that involved in the metabolism many xenobiotics, including wide range environmental carcinogens. While null genotypes GSTM1 and GSTT1 have been implicated tumor genesis, it remains inconsistent inconclusive. Herein, we aimed to assess possible associations genotype cancer risks.
Objective: Nuclear auto-antigenic sperm protein (NASP), initially described as a highly auto-immunogenic testis and sperm-specific protein, is histone chaperone that proved to present in all dividing cells. NASP has two splice variants: testicular (tNASP) somatic form of (sNASP). Only cancer, germ, transformed, embryonic cells have high level expression the tNASP. Up now, little been known about tNASP renal cell carcinoma (RCC). In study, molecular mechanism RCC was explored.
Objective: The incidence of renal cell carcinoma (RCC) has been steadily rising each year. There are currently few recognized biomarkers for the diagnosis and prognosis RCC.