A5062985408- Parasites and Host Interactions
- Phytochemistry and Biological Activities
- Liver physiology and pathology
- Pulmonary Hypertension Research and Treatments
- Ginseng Biological Effects and Applications
- Phytochemistry and biological activity of medicinal plants
- Natural product bioactivities and synthesis
- Phytochemistry and Bioactive Compounds
- Renin-Angiotensin System Studies
- Pharmacological Effects of Natural Compounds
- Signaling Pathways in Disease
- Essential Oils and Antimicrobial Activity
- Galectins and Cancer Biology
- Heart rate and cardiovascular health
- PI3K/AKT/mTOR signaling in cancer
- Spine and Intervertebral Disc Pathology
- Piperaceae Chemical and Biological Studies
- Hepatitis Viruses Studies and Epidemiology
- Spinal Fractures and Fixation Techniques
- Medicinal Plants and Bioactive Compounds
- Nitric Oxide and Endothelin Effects
- Cancer Cells and Metastasis
- Eicosanoids and Hypertension Pharmacology
- Liver Diseases and Immunity
- Receptor Mechanisms and Signaling
Yunnan University of Traditional Chinese Medicine
2025
Nanjing Medical University
2009-2024
Guizhou University
2024
Jiangsu University
2023-2024
Affiliated Hospital of Jiangsu University
2024
First People's Hospital of Foshan
2023
Wangjing Hospital of China Academy of Chinese Medical Sciences
2010-2022
Central South University
2022
Kunming Institute of Botany
2009-2014
Chinese Academy of Sciences
2009-2014
(+)-Lingzhiol and (−)-lingzhiol, a pair of rotary door-shaped meroterpenoidal enantiomers, were isolated from Ganoderma lucidum. Their structures identified by spectroscopic methods X-ray diffraction crystallography. Lingzhiol bears an unusual 5/5/6/6 ring system characteristic sharing C-3′–C-7′ axis. Biological evaluation showed that (+)-lingzhiol or (−)-lingzhiol could selectively inhibit the phosphorylation Smad3 in TGF-β1-induced rat renal proximal tubular cells activate Nrf2/Keap1...
Inflammation plays a critical role in the development of diabetic cardiomyopathy (DCM), which has been identified as major predisposing factor for heart failure patients. Previous studies indicated that ivabradine (a specific agent rate [HR] reduction) anti‐inflammatory properties, but its DCM remains unknown. This study investigated whether exerts therapeutic effect DCM. C57BL/6J mice were injected intraperitoneally with streptozotocin (STZ) to induce diabetes; then administered or saline...
Background Schistosomiasis is a parasitic disease infecting more than 200 million people in the world. Although chemotherapy targeting on killing schistosomes one of main strategies control, there are few effective ways dealing with liver fibrosis caused by parasite infection chronic and advanced stages schistosomiasis. For this reason, new prospective drugs, which exert antifibrotic effects, urgently required. Methods Findings The effects praziquantel were assessed murine models...
(±)-Aspongamide A (1), an unusual trimer of N-acetyldopamine (NADA) bearing a novel tetrahydrobenzo[a]dibenzo[b,e][1,4]dioxine structure, and pair NADA dimeric enantiomers (2) were isolated from Aspongopus chinensis. The structures compounds 1 2 assigned using spectroscopic methods. Compound was found to be inhibitor Smad3 phosphorylation in transforming growth factor-β1 (TGF-β1) induced rat renal proximal tubular cells suppressed extracellular matrix expression mesangial under diabetic conditions.
Formononetin has been demonstrated to protect against cerebral ischemia–reperfusion injury, however its mechanism be further researched. This study examined the effect of formononetin on injury in rats using PARP-1/PARG/Iduna signaling pathway. In male SD rats, a model was developed. Animals were randomly assigned one eight groups: Sham operation, operation + formononetin, MCAO, MCAO PARP inhibitor (PJ34) PJ34 PARG (Ethacridine lactate) and ethacridine lactate formononetin. The neurological...
Swerilactones H-K (1-4), which are four novel lactones with an unprecedented C29 skeleton, were isolated from Swertia mileensis (Qing-Ye-Dan), endemic Chinese herb used for treating viral hepatitis. Their structures determined by extensive spectroscopic and X-ray crystallographic diffraction analyses. exhibit potent anti-hepatitis B virus activity against HBV DNA replication IC(50) values ranging 1.53 to 5.34 μM. For the first time, a plausible biogenetic pathway swerilactones H-K, together...
Reactive oxygen species (ROS) contribute to many aspects of physiological and pathological cardiovascular processes. However, the underlying mechanism ROS induction by low shear stress (LSS) remains unclear. Accumulating evidence has shown that angiotensin II type 1 receptor (AT1R) is involved in inflammation, apoptosis, production. Our aim was explore role AT1R LSS-mediated induction. We exposed human umbilical vein endothelial cells (HUVECs) LSS (3 dyn/cm2 ) for different periods time....
The difficulty of diabetic nephropathy (DN) treatment makes prevention the best choice. Cinnamomum cassia barks, known as Chinese cinnamon or cassia, is one most popular natural spices and flavoring agents in many parts World. Since previous reports indicated that extract could be used for diabetes, we proposed this spice may beneficial DN. However, responsible compounds need to further identified. In study, isolated three new phenolic glycosides, cinnacassosides A-C (1-3), together with...
Two new oxanthrone C-glycosides, patientosides A (14) and B (15), together with three known ones (11-13), were isolated from Rumex patientia. Their structures identified on the basis of spectroscopic methods. The absolute configuration for 14 15 deduced by analysis their CD spectra comparison those similar compounds. Compounds 11-15, anthraquinones (1-4, 6-10, 16-20) previously nepalensis, hastatus, endophytic Aspergillus fumigatus, respectively, as well a commercially available compound...
The activation of hepatic stellate cells (HSCs) is a key event in fibrotic pathogenesis. However, the mechanism involving HSCs chronic schistosomiasis not entirely clear. Human HSC LX‐2 and human umbilical vein endothelial (ECs) were cultured with Schistosoma japonicum antigens (SA) vitro . Fibrosis‐associated genes cell proliferation analyzed. isolated from mice or without praziquantel (PZQ) treatment, followed by microarray analysis for liver fibrosis‐associated pathways. Although SA...
Previous studies have suggested that exogenous hydrogen sulfide can alleviate the development of diabetic cardiomyopathy (DCM) by inhibiting oxidative stress, inflammation, and apoptosis. However, underlying mechanism is not fully understood. Nuclear expression function transcription factor Forkhead box protein O (FoxO1) been associated with cardiovascular diseases, thus, importance FoxO1 in DCM has gained increasing attention. This study was designed to investigate interactions between (H2...
Recent studies reported that atorvastatin (ATOR) alleviated progression of experimental diabetic cardiomyopathy (DCM), possibly by protecting against apoptosis. However, the underlying mechanisms this protective effect remain unclear. Therefore, our study investigated role glycogen synthase kinase (GSK)-3β-protein phosphatase 2A(PP2A)-NF-κB signaling pathway in anti-apoptotic and cardioprotective effects ATOR on cardiomyocytes cultured high glucose (HG) DCM. Our results showed that,...
Hepatic stellate cells (HSCs) play a key role in the development of liver fibrosis caused by schistosomiasis. Chemokines were widely expressed and involved cellular activation, proliferation migration inflammatory infectious diseases. However, little is known about expressions chemokines on HSCs schistosoma infection. In addition, roles pathogenesis are not totally clear. our study, we used microarray to analyze temporal gene primary isolated from mice with both acute chronic Our data showed...
Toxicodenanes A–C (1–3), representing sesquiterpenoids with three new carbon skeletons, were isolated from the dried resin of Toxicodendron vernicifluum. Their structures identified by spectroscopic data and X-ray diffraction crystallography. plausible biosynthetic route was proposed via intermediate (4). Compounds 2 3 could significantly inhibit overproduction fibronectin, collagen IV, IL-6 in high-glucose-induced mesangial cells a dose- time-dependent manner, showing their potential...
Excessive proliferation, migration, and antiapoptosis of pulmonary artery (PA) smooth muscle cells (PASMCs) underlies the development vascular remodeling. The innervation PA is predominantly sympathetic, increased levels circulating catecholamines have been detected in arterial hypertension (PAH), suggesting that neurotransmitters released by sympathetic overactivation may play an essential role PAH. However, responsible mechanism remains unclear. Here, to investigate effects norepinephrine...
Swerilactones C (1) and D (2), two novel diastereomeric lactones with an unprecedented 6/6/6/6/6 pentacyclic ring system, were isolated from the traditional Chinese herb Swertia mileensis. Their structures relative stereochemistry elucidated on basis of spectroscopic methods further confirmed by X-ray single-crystal diffraction analysis. In vitro antihepatitis B virus (HBV) assay Hep G 2.2.15 cell line showed that both compounds 1 2 exhibited inhibitory activities against secretion HBsAg...