A5071561307- Chinese history and philosophy
- Regional Economic and Spatial Analysis
- Diverse Aspects of Tourism Research
- Herpesvirus Infections and Treatments
- Higher Education and Teaching Methods
- China's Socioeconomic Reforms and Governance
- Digital Media and Visual Art
- Global trade and economics
- Economic Zones and Regional Development
- Evaluation Methods in Various Fields
- Global Financial Crisis and Policies
- Educational Reforms and Innovations
- Cytomegalovirus and herpesvirus research
- Asian Culture and Media Studies
- Cruise Tourism Development and Management
- RNA regulation and disease
- Advanced Image and Video Retrieval Techniques
- Global Trade and Competitiveness
- Tryptophan and brain disorders
- Forest, Soil, and Plant Ecology in China
- Treatment of Major Depression
- E-commerce and Technology Innovations
- Industrial Technology and Control Systems
- Education and Work Dynamics
- Evacuation and Crowd Dynamics
Chinese Academy of Sciences
2011-2025
Aerospace Information Research Institute
2022-2025
Sichuan University
2010-2024
Northwestern Polytechnical University
2023-2024
University of Chinese Academy of Sciences
2017-2022
Center for Excellence in Brain Science and Intelligence Technology
2017-2022
Wuhan Institute of Virology
2017-2022
West China Medical Center of Sichuan University
2018-2022
Mirna Therapeutics (United States)
2022
Sino-Danish Centre for Education and Research
2020
Cell therapy is a potential therapeutic approach for neurodegenerative disorders, such as Alzheimer disease (AD). Neuronal differentiation of stem cells before transplantation promising procedure cell therapy. However, the impact and mechanisms action neuron-like differentiated from human umbilical cord mesenchymal in AD have not been determined.In this study, we used tricyclodecan-9-yl-xanthogenate (D609) to induce isolated Wharton jelly (HUMSCs) differentiate into (HUMSC-NCs), transplanted...
Herpes simplex virus type 1 strain 129 (H129) has represented a promising anterograde neuronal circuit tracing tool, which complements the existing retrograde tracers. However, current H129 derived tracers are multisynaptic, neither bright enough to label details of neurons nor capable determining direct projection targets as monosynaptic tracer.Based on bacterial artificial chromosome H129, we have generated serial recombinant viruses for tracing. Among them, H129-G4 was obtained by...
Abstract Rabies is a lethal zoonotic disease that mainly caused by the rabies virus (RABV). Although effective vaccines have long existed, current take both time and cost to produce. Messenger RNA (mRNA) technology an emergent vaccine platform supports rapid development on large scale. Here, optimized mRNA construct (LVRNA001) expressing glycoprotein (RABV-G) was developed in vitro then evaluated vivo for its immunogenicity protective capacity mice dogs. LVRNA001 induced neutralizing...
Feature pyramid network transformer decoder (FPNFormer) module, which can effectively deal with the strong rotation arbitrary of remote sensing images while improving expressiveness and robustness model. It is a plug-and-play module that be well transferred to various detection models significantly improves performance. Specifically, we use computational method problem image has any orientation, its output weakly depends on order input data. We apply it feature fusion stage design two ways...
Abstract Monosynaptic viral tracers are essential tools for dissecting neuronal connectomes and targeted delivery of molecular sensors effectors. Viral toxicity complex multi-injection protocols major limiting application barriers. To overcome these barriers, we developed an anterograde monosynaptic H129 Amp tracer system based on HSV-1 strain H129. The consists two components: H129-dTK-T2- pac Flox helper which assists tracer’s propagation transneuronal transmission. shared features...
Aerial optical cameras are the primary method for capturing high-resolution images to produce large-scale mapping products. To improve aerial photography efficiency, multiple often used in combination generate large-format virtual central projection images. This paper presents a high-precision directly transforming raw obtained from dual-camera system mounted at an oblique angle into images, thereby enabling construction of low-cost, camera systems. The commences with adaptive sub-block...
Background: A chronic pancreatitis model was developed in young male Lewis rats fed a high-fat and alcohol liquid diet beginning at three weeks. The used to assess time course efficacy of replication defective herpes simplex virus type 1 vector construct delivering human cDNA encoding preproenkephalin (HSV-ENK). Results: Most surprising the relative lack inflammation tissue disruption after HSV-ENK treatment compared histopathology consistent with (inflammatory cell infiltration, edema,...
Although a varicella-zoster virus (VZV) vaccine has been used for many years, the neuropathy caused by VZV infection is still major health concern. Open reading frame 7 (ORF7) of recognized as neurotropic gene in vivo, but its neurovirulent role remains unclear. In present study, we investigated effect ORF7 deletion on replication cycle at entry, genome replication, expression, capsid assembly and cytoplasmic envelopment, transcellular transmission differentiated neural progenitor cells...
We examine the stability and strength of relationship between exchange rates trade over time using three alternative approaches, mitigating endogeneity relation.We find that both rate pass-through price elasticity volumes are largely stable time.Economic slack financial conditions affect relationship, but there is limited evidence participation in global value chains has significantly changed rate-trade time.
Marek's disease virus (MDV) is an oncogenic avian herpesvirus whose genomic structure similar to those of herpes simplex and varicella-zoster virus. Repeat regions the MDV genome have been intensively investigated because a potential relationship oncogenicity abundant expression immediate-early transcripts. In this study, 1.6-kb transcript was localized BamHI-I2 region by Northern (RNA) hybridization analysis. With cDNA cloning sequencing, two cDNAs 1.4 kb (C1) 1.35 (C2) were identified....
Thalamic intralaminar and medial nuclei participate mainly in affective motivational aspects of pain processing. Unique to the present study were identification characterization spontaneously active neurons central lateral nucleus (CL) thalamus, which found respond only viscerally evoked noxious stimuli animals under pentobarbital anesthesia. Responses colorectal distention, intrapancreatic bradykinin, intraperitoneal dilute acetic acid, greater splanchnic nerve electrical stimulation...
WD repeat-containing protein 5 (WDR5) is essential for assembling the VISA-associated complex to induce a type I interferon antiviral response Sendai virus infection. However, roles of WDR5 in DNA infections are not well described. Here, we report that human cytomegalovirus exploits facilitate capsid nuclear egress. Overexpression fibroblasts slightly enhanced infectious yield. knockdown dramatically reduced titers with only small decrease viral genome replication or gene expression. Further...
Environmental stability technology plays an important role in improving the adaptive range, image resolution and ensuring of geometric parameters aerial mapping camera. Traditional environmental methods directly implement active passive thermal design to optical systems, which is easy lead radial temperature difference components, cannot eliminate influence pressure change. To solve above problem, a method environment based on multi-dimensional structure proposed. Firstly, camera designed as...
Purpose The purpose of this paper is to elaborate on the interactive conflicts between business and governmental authorities in regulatory process an emerging model: sharing economy. Focusing bike system, study also investigates conflict-handling strategy companies government regulation. Design/methodology/approach An evolutionary game model introduced illustrate conflict regulation, combined with system dynamics (SD) simulate strategies two players. Findings dynamic players are observed,...
We examine the stability and strength of relationship between exchange rates trade over time using three alternative approaches, mitigating endogeneity relation. find that both rate pass-through price elasticity volumes are largely stable time. Economic slack financial conditions affect relationship, but there is limited evidence participation in global value chains has significantly changed rate-trade
Viral tracers are important tools for mapping brain connectomes. The feature of predominant anterograde transneuronal transmission offers herpes simplex virus-1 (HSV-1) strain H129 (HSV1-H129) as a promising candidate to be developed viral tracers. In our earlier studies, we H129-derived polysynaptic and TK deficient (H129-dTK) monosynaptic However, their broad application is limited by some intrinsic drawbacks the H129-dTK tracers, such low labeling intensity due deficiency potential...
Human cytomegalovirus (HCMV) has a large (∼235 kb) genome with more than 200 predicted open reading frames that exploits numerous cellular factors to facilitate its replication. A key feature of HCMV-infected cells is the emergence distinctive membranous cytoplasmic compartment termed virion assembly (vAC). Here, we report host protein WD repeat domain 11 (WDR11) plays role in vAC formation and morphogenesis. We found WDR11 was upregulated at both mRNA levels during HCMV infection. At late...