A5011433958- Sleep and related disorders
- Sleep and Wakefulness Research
- Diet and metabolism studies
- Obesity, Physical Activity, Diet
- Liver Disease Diagnosis and Treatment
- Nutritional Studies and Diet
- Circadian rhythm and melatonin
- Nutrition and Health in Aging
- Frailty in Older Adults
- Cardiovascular Health and Risk Factors
- Blood Pressure and Hypertension Studies
- Cardiac Health and Mental Health
- Sleep and Work-Related Fatigue
- Diet, Metabolism, and Disease
- Chronic Disease Management Strategies
- Genetic Associations and Epidemiology
- Metabolomics and Mass Spectrometry Studies
- Physical Activity and Health
- Electroconvulsive Therapy Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Treatment of Major Depression
- Diabetes Management and Research
- Health disparities and outcomes
- Metabolism, Diabetes, and Cancer
- Health Systems, Economic Evaluations, Quality of Life
Uppsala University
2017-2025
Zhejiang University
2022-2025
Sir Run Run Shaw Hospital
2022-2025
Karolinska Institutet
2021-2025
Institute of Mental Health
2019-2025
Affiliated Hospital of North Sichuan Medical College
2025
Shanghai Ninth People's Hospital
2022-2024
Shanghai Jiao Tong University
2008-2024
Guangzhou University
2023
Second Affiliated Hospital of Nanchang University
2023
Observational studies have suggested strong associations between sleep duration and many cardiovascular diseases (CVDs), but causal inferences not been confirmed. We aimed to determine the genetically predicted 12 CVDs using both linear nonlinear Mendelian randomization (MR) designs.Genetic variants associated with continuous, short (≤6 h) long (≥9 durations were used examine among 404 044 UK Biobank participants of White British ancestry. Linear MR analyses showed that was negatively...
The aim of this study was to test whether current and past night shift work associated with incident atrial fibrillation (AF) association modified by genetic vulnerability. Its associations coronary heart disease (CHD), stroke, failure (HF) were measured as a secondary aim.This cohort included 283 657 participants in paid employment or self-employed without AF 276 009 free CHD, HF at baseline the UK Biobank. Current lifetime information obtained. Cox proportional hazard models used. Weighted...
There is a growing interest in the role of timing daily behaviors improving health. However, little known about optimal physical activity to maximize health benefits. We perform cohort study 92,139 UK Biobank participants with valid accelerometer data and all-cause cause-specific mortality outcomes, comprising over 7 years median follow-up (638,825 person-years). Moderate-to-vigorous intensity (MVPA) at any time day associated lower risks for all-cause, cardiovascular disease, cancer...
Atrial fibrillation (AF) is the most common sustained arrhythmia in adults. Investigations of risk factor profiles for AF according to age and genetic groups are essential promote individualized strategies prevention control AF.A total 409 661 participants (mean age, 56 years; 46% men) free at baseline with complete information about factors were included from UK Biobank cohort. The hazard ratios population-attributable (PAR) percentages incident associated 23 examined, including 3 social...
Importance Understanding the interplay between sleep duration, dietary habits, and risk of developing type 2 diabetes (T2D) is crucial for public health prevention strategies. Objective To investigate associations diet duration with development T2D. Design, Setting, Participants Data derived from UK Biobank baseline investigation (2006-2010) were analyzed this cohort study May 1 September 30, 2023. The association healthy patterns T2D was investigated during a median (IQR) follow-up 12.5...
Clonal haematopoiesis of indeterminate potential (CHIP) is associated with macrovascular diseases, including coronary artery disease and stroke. However, the effects CHIP on microvascular complication have not been evaluated in individuals type 2 diabetes (T2D). This study included 20,712 T2D participants without prevalent diabetic (DMCs) hematologic malignancy at baseline. related phenotypes were identified using whole exome sequencing derived from peripheral blood samples. The incidence...
The study aimed to assess whether aerobic exercise (AEx) training and a fibre-enriched diet can reduce hepatic fat content (HFC) increase glycaemic control in pre-diabetic patients with non-alcoholic fatty liver disease (NAFLD). Six-hundred-and-three from seven clinics Yangpu district, Shanghai, China were recruited. Of them 115 individuals aged 50-65-year fulfilled the inclusion criteria (NAFLD impaired fasting glucose or tolerance) randomly assigned into (AEx n = 29), (Diet 28), plus (AED...
To evaluate the association of cardiovascular health (CVH), measured by Life's Essential 8 score, with risk premature mortality and to determine patterns CVH-related differences in life expectancy among people without type 2 diabetes (T2D).This prospective study included 309,789 participants (age 56.6 ± 8.1 years; 46% men) enroled UK Biobank. The composite measure consists four behaviours (diet, physical activity, nicotine exposure, sleep) factors (BMI, non-HDL cholesterol, blood glucose,...
Abstract Background Observational studies have found that both short and long sleep duration are associated with increased risk of metabolic syndrome (MetS). This study aimed to examine the associations genetically determined durations MetS its five components (i.e., central obesity, high blood pressure, dyslipidemia, hypertriglyceridemia, hyperglycemia) among a group elderly population. Methods In 335,727 participants White British from UK Biobank, linear Mendelian randomization (MR)...
Sodium-glucose cotransporter 2 (SGLT2) inhibitors have shown promise in reducing the risk of atrial fibrillation (AF). However, results are controversial and underlying metabolic mechanism remains unclear. Emerging evidence implied that SGLT2 extra beneficial effects on circulating metabolites beyond glucose control, which might play a role AF. Hence, our study aimed to investigate effect mediating inhibition AF by Mendelian randomization (MR).A two-sample two-step MR was conducted evaluate...
BackgroundThe health effects of rest–activity rhythm are major interest to public health, but its associations with outcomes remain elusive. We aimed examine the between accelerometer-measured amplitude and risks among general UK population.MethodsWe did a prospective cohort analysis Biobank participants aged 43–79 years valid wrist-worn accelerometer data. Low was defined as first quintile relative amplitude; all other quintiles were classified high amplitude. Outcomes using International...
The aim of the current study was to investigate association accelerometer-measured sleep duration and different intensities physical activity (PA) with risk incident type 2 diabetes in a population-based prospective cohort study. Altogether, 88,000 participants (mean age = 62.2 ± 7.9 years, mean SD) were included from UK Biobank. Sleep (short: <6 h/day; normal: 6–8 long: >8 h/day) PA measured using wrist-worn accelerometer over 7-day period between 2013 2015. classified according median or...
Abstract Background Type 2 diabetes (T2D) is associated with an increased risk of premature death. Whether multifactorial factor modification could attenuate T2D-related excess death unclear. We aimed to examine the association target achievement mortality and life expectancy among patients T2D, compared individuals without diabetes. Methods In this longitudinal cohort study, we included 316 995 participants (14 162 T2D 302 833 T2D) free from cardiovascular disease (CVD) or cancer at...
BACKGROUND: An association between sweetened beverages and several cardiometabolic diseases has been reported, but their with atrial fibrillation (AF) is unclear. We aimed to investigate the associations consumption of sugar-sweetened (SSB), artificially (ASB), pure fruit juice (PJ) risk AF further evaluate whether genetic susceptibility modifies these associations. METHODS: A total 201 856 participants who were free baseline AF, had data available, completed a 24-hour diet questionnaire...
<p dir="ltr">Clonal haematopoiesis of indeterminate potential (CHIP) is associated with macrovascular diseases, including coronary artery disease and stroke. However, the effects CHIP on microvascular complication have not been evaluated in individuals type 2 diabetes (T2D). This study included 20,712 T2D participants without prevalent diabetic (DMCs) hematologic malignancy at baseline. related phenotypes were identified using whole exome sequencing derived from peripheral blood...
Hyperthermia (HT) has broad potential for disease treatment and health maintenance. Previous studies have shown that far-infrared rays (FIRs) at 8-10 μm can potentially reduce inflammation, oxidative stress, gut microbiota imbalance. However, the effects of FIR HT on energy metabolism require further investigation. To investigate graphene-FIR therapy diet-induced obesity their regulatory mechanisms in disorders. After 8 weeks hyperthermia, mice fed standard chow or a high-fat diet (HFD)...
Clonal hematopoiesis of indeterminate potential (CHIP), characterized by the age-related expansion blood cells carrying preleukemic mutations, is associated with immune aging. This study aimed to investigate association between CHIP and established autoimmune diseases. We analyzed baseline data from 456,692 UK Biobank participants available whole-exome sequences. The primary outcome was 19 disorders. Associations among any (variant allele fraction ≥2%), large clones ≥10%), gene-specific...
Summary This cross‐sectional study aimed to investigate whether body fat distribution, physical activity levels and dietary intakes are associated with insomnia and/or obstructive sleep apnea among overweight middle‐aged men. Participants were 211 Finnish men aged 30–65 years. Among the 163 or obese participants, 40 had only, 23 24 comorbid 76 without disorder. The remaining 48 participants normal weight Fat mass, of diet assessed by dual‐energy X‐ray densitometry, questionnaire 3‐day food...
The aim of this study was to investigate the association between cardiorespiratory fitness and gut microbiota composition in premenopausal women. participants consisted 71 Finnish women (aged 19-49 years). Gut were analyzed using flow cytometry, 16S rRNA gene hybridization DNA-staining. Maximum oxygen uptake (VO2max) assessed by respiratory gas analyzer body Bioimpdance. We found that with low VO2max had lower Bacteroides, but higher Eubacterium rectale-Clostridium coccoides than high group...
Sleep duration and sleep quality are often linked to increased risk of mortality morbidity. However, national representative data on both their relationship with chronic health problems rarely available from the same source. This current study aimed examine independent combined associations physical mental disorders, using Singapore Mental Health Study 2016. 6,126 residents aged ≥18years participated in this epidemiological, cross-sectional survey. measures were assessed Pittsburg Quality...