A5039983775- Cardiovascular Disease and Adiposity
- Adipokines, Inflammation, and Metabolic Diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Thermoregulation and physiological responses
- Heat shock proteins research
- Obesity, Physical Activity, Diet
- Cancer Mechanisms and Therapy
- Lipoproteins and Cardiovascular Health
- Cancer-related molecular mechanisms research
- Nutrition and Health in Aging
- Diabetes Treatment and Management
- Cardiovascular Health and Disease Prevention
- MRI in cancer diagnosis
- Cancer Immunotherapy and Biomarkers
- Blood Pressure and Hypertension Studies
- Cancer, Lipids, and Metabolism
- Spaceflight effects on biology
- Nuts composition and effects
- Genetic factors in colorectal cancer
- Radiomics and Machine Learning in Medical Imaging
- Nuclear Receptors and Signaling
Peking University
2021-2025
Second Affiliated Hospital of Xi'an Jiaotong University
2021-2025
National Institutes for Food and Drug Control
2025
Peking Union Medical College Hospital
2013-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2024
Shandong University
2020-2024
Sixth Affiliated Hospital of Sun Yat-sen University
2023
Sun Yat-sen University
2023
Second Military Medical University
2022
Eastern Hepatobiliary Surgery Hospital
2022
Observational studies have suggested strong associations between sleep duration and many cardiovascular diseases (CVDs), but causal inferences not been confirmed. We aimed to determine the genetically predicted 12 CVDs using both linear nonlinear Mendelian randomization (MR) designs.Genetic variants associated with continuous, short (≤6 h) long (≥9 durations were used examine among 404 044 UK Biobank participants of White British ancestry. Linear MR analyses showed that was negatively...
Combining lenvatinib with a programmed cell death protein-1 (PD-1) inhibitor has been explored for the treatment of un-resectable hepatocellular carcinoma (uHCC). This study aimed to investigate real-world efficacy and prognostic factors survival associated plus PD-1 in large cohort Asian uHCC patients even global LEAP-002 failed achieve primary endpoints.
Abstract Background Microsatellite instability-high (MSI-H) is a unique genomic status in many cancers. However, its role the features and immunotherapy cholangiocarcinoma (CCA) unclear. This study aimed to systematically investigate characterization efficacy of MSI-H patients with CCA. Methods We enrolled 887 CCA this study. Tumor samples were collected for next-generation sequencing. Differences alterations between microsatellite stability (MSS) groups analyzed. also investigated survival...
Abstract Background The triglyceride-glucose (TyG) index is regarded as a sophisticated surrogate biomarker for insulin resistance, offering refined means evaluating cardiovascular diseases (CVDs). However, prospective cohort studies have not simultaneously conducted baseline and multi-timepoint trajectory assessments of the TyG in relation to CVDs their subtypes elderly participants. Methods After excluding data deficiencies conditions that could influence research outcomes, this study...
Several studies have shown that patients with anti-MDA5 antibody-positive dermatomyositis (anti-MDA5 antibody + DM) an increased risk of developing rapid progression interstitial lung disease (RPILD), which is associated poor prognosis and high mortality. However, diagnosis treatment are often delayed due to atypical early clinical features heterogeneity. Therefore, should be identified establish a model for identification intervention, thereby improving the patients. The study aimed...
Abstract Background The mid-upper arm circumference (MUAC) is a proxy for subcutaneous fat in the upper body and reliable screening measure identifying individuals with abnormal regional distribution. purpose of this study was to evaluate association between MUAC metabolic syndrome (MetS) middle-aged elderly individuals. Methods We measured cross-sectional sample total 9787 subjects aged 40 years older. measurement performed on right using non-elastic tape held midway acromion olecranon...
This study aimed to assess the efficacy and safety of a triple therapy that comprises transarterial chemoembolization (TACE), antiangiogenic-targeted therapy, programmed death-1 (PD-1) inhibitors in real-world cohort patients with unresectable hepatocellular carcinoma (HCC) portal vein tumor thrombus (PVTT).Consecutive treated TACE combined antiangiogenic PD-1 at Eastern Hepatobiliary Surgery Hospital between June 2019 May 2021 were enrolled. The baseline characteristics treatment course...
Abstract Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates cholesterol metabolism by targeting the low-density lipoprotein receptor. Recent studies have shown that circulating PCSK9 is associated with glucose homeostasis and insulin resistance. The aim of this study was to examine association levels risk for development 2 diabetes in individuals prediabetes. Methods A population-based prospective conducted among 4205 Chinese subjects prediabetes (average age 56.1 ±...
Objective Growth differentiation factor 15 (GDF-15) is a member of the TGF- β superfamily that has anti-inflammatory properties. The objective this study was to evaluate relationship between circulating GDF-15 levels and diabetic retinopathy (DR) in patients with type 2 diabetes. Materials/Methods A case–control performed which 402 diabetes were enrolled. Of these, 171 had DR remaining 231 without acted as controls. plasma measured using ELISA, while diagnosed canon ophthalmic digital...
Background: Neutrophil-lymphocyte ratio (NLR) is a novel marker of inflammation. Emerging studies have evaluated the relationship NLR with cardiovascular diseases and malignant conditions. However, rare regarded association between long-term health status. This study aimed to evaluate all-cause mortality cause-specific among adults in United States. Methods: We obtained eight cycles data National Health Nutrition Examination Surveys (NHANES) from 1999 2014, enrolled 32328 participants after...
Choledochal cyst (CDC) increases the risk (2.5%-30%) of malignancy. Metaplasia and dysplasia have been recognized as premalignant lesions among CDCs. This study aimed to evaluate factors metaplasia in CDC children. Two hundred ten children who underwent excision Roux-en-Y hepaticojejunostomy at our institution between July 2020 November 2021 were included randomly divided into training set validation set. Univariate multivariate logistic regression analysis used identify independent build a...
Abstract Background Heat shock protein 27 (HSP27) has been proposed as a vital protective factor in atherosclerosis. The objective of the present study was to evaluate association between circulating HSP27 and carotid intima–media thickness (IMT) individuals with type 2 diabetes determine whether represents an independent marker subclinical atherosclerosis this patient population. Methods We performed cross-sectional community-based 186 Chinese subjects median duration 8.2 years who...
Background Previous studies reported that proprotein convertase subtilisin/kexin type 9 (PCSK9) was a key player in the regulations of lipid metabolism and glucose homeostasis. The current study aimed to detect expression PCSK9 pregnant women with gestational diabetes mellitus (GDM) investigate possible relationships between related metabolic phenotypes GDM. Methods Circulating levels were determined by ELISA kit cohort subjects GDM (n = 170) normal tolerance (NGT; n 130). We collected blood...
Healthy adipose tissue is crucial to maintain normal energy homeostasis. Little known about the role of murine double minute 2 (MDM2), an E3 ubiquitin ligase and has been highlighted in oncopathology, tissue. Our results indicated that MDM2 expression was associated with nutritional status. Mdm2 adipocyte-specific knock-in (Mdm2-AKI) mice exhibited exacerbated weight gain, insulin resistance, decreased expenditure. Meanwhile, chronic high-fat diet (HFD) exposure caused obvious epididymal...
In this study, we aimed to explore the associations between HLA-A\B\DRB1 polymorphisms and risks of vulvar lichen sclerosus (VLS) or squamous cell hyperplasia vulva (SCHV) in Han Chinese women. We enrolled 76 women with VLS (Group A), 74 SCHV B), 66 healthy (control group) study. Polymerase chain reaction amplification sequence specific primers (PCR-SSP) was used determine polymorphisms. Compared control group, HLA-A*11, -B*15, -DRB1*12 were present at a higher frequency groups A B, while...
Background Cathepsin S, as an adipokine, was reported to play a critical role in various disease, including atherosclerosis and diabetes. The present study aims elucidate the relationship between circulating cathepsin S cardiovascular disease (CVD) patients with type 2 Methods A total of 339 diabetes individuals were enrolled this cross-sectional community-based study. Basic information, medical laboratory data collected. Serum levels assessed by ELISA. Results Compared CVD (−) group, serum...
Abstract Background Neck circumference, a proxy for upper-body subcutaneous fat, is unique and pathogenic fat depot that confers additional metabolic risk. The purpose of present study was to determine whether neck circumference associates with nonalcoholic fatty liver disease (NAFLD) in postmenopausal women normal body mass index. Methods A cross-sectional survey (n = 2492) 3.1-year follow-up investigation 1354) were conducted among Chinese BMI (18.5 < 25 kg/m 2 ). measured horizontally...
A small thigh circumference is associated with an increased risk of diabetes, cardiovascular diseases, and total mortality. The purpose this study was to evaluate the association between hypertension in middle-aged elderly population.A 9520 individuals aged 40 years older measurement were available for analysis. performed directly below gluteal fold thigh. tested logistic regression analyses reported as odds ratio (OR) 95% CI.Thigh negatively correlated systolic blood pressure, diastolic...