A5107519773- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Lipid metabolism and disorders
- Peroxisome Proliferator-Activated Receptors
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Advanced ceramic materials synthesis
- Hip and Femur Fractures
- Dialysis and Renal Disease Management
- Research in Cotton Cultivation
- Lipid metabolism and biosynthesis
- Pancreatic function and diabetes
- Renal cell carcinoma treatment
- Sperm and Testicular Function
- Chronic Kidney Disease and Diabetes
- Multicomponent Synthesis of Heterocycles
- Intermetallics and Advanced Alloy Properties
- Renal Diseases and Glomerulopathies
- Polyamine Metabolism and Applications
- Fiber-reinforced polymer composites
- Receptor Mechanisms and Signaling
- Hormonal and reproductive studies
- Ubiquitin and proteasome pathways
- Composite Material Mechanics
Hangzhou Hospital of Traditional Chinese Medicine
2025
Zhejiang Chinese Medical University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Xingtai People's Hospital
2024
University of Chinese Academy of Sciences
2024
Tianjin Institute of Industrial Biotechnology
2024
Chinese Academy of Sciences
2024
Hebei Medical University
2024
Wuhan University
2021
Ministry of Education of the People's Republic of China
2015
Background In diabetic patients, non-diabetic kidney disease (NDKD) may occur independently or alongside (DKD). This study explored the utility of biopsy in type 2 diabetes mellitus (T2DM) patients and predictability diagnosing DKD combined with NDKD using clinical laboratory data. Methods retrospective examines medical records T2DM who underwent percutaneous renal at Hangzhou TCM Hospital, Zhejiang Chinese Medical University, from 2012 to 2023. The patient’s demographic, clinical, blood...
Abstract Background Metastasis renal cell carcinoma (RCC) patients have extremely high mortality rate. A predictive model for RCC micrometastasis based on pathomics could be beneficial clinicians to make treatment decisions. Methods total of 895 formalin-fixed and paraffin-embedded whole slide images (WSIs) derived from three cohorts, including Shanghai General Hospital (SGH), Clinical Proteomic Tumor Analysis Consortium (CPTAC) Cancer Genome Atlas (TCGA) another 588 frozen section WSIs TCGA...
Utilizing<italic>N</italic>,<italic>N</italic>′-bis(carboxymethyl)-<sc>L</sc>-lysine (ANTA) combined with bivalent metal cation Ni<sup>2+</sup>, which leaving free sites for the reversible binding of gene recombinant histidine-tagged β<sub>2</sub>-adrenoceptor onto silica gel.
Healthy adipose tissue is crucial to maintain normal energy homeostasis. Little known about the role of murine double minute 2 (MDM2), an E3 ubiquitin ligase and has been highlighted in oncopathology, tissue. Our results indicated that MDM2 expression was associated with nutritional status. Mdm2 adipocyte-specific knock-in (Mdm2-AKI) mice exhibited exacerbated weight gain, insulin resistance, decreased expenditure. Meanwhile, chronic high-fat diet (HFD) exposure caused obvious epididymal...
LncRNAs are involved in modulating the individual risk and severity of progression metabolic dysfunction-associated fatty liver disease (MASLD), but their precise roles remain largely unknown. This study aimed to investigate role lncRNA Snhg3 development MASLD, along with underlying mechanisms. The result showed that was significantly downregulated high-fat diet-induced obesity (DIO) mice. Notably, palmitic acid promoted expression overexpression increased lipid accumulation primary...
LncRNAs are involved in modulating the individual risk and severity of progression metabolic dysfunction-associated fatty liver disease (MASLD), but their precise roles remain largely unknown. This study aimed to investigate role lncRNA Snhg3 development MASLD, along with underlying mechanisms. The result showed that was significantly downregulated high-fat diet-induced obesity (DIO) mice. Notably, palmitic acid promoted expression overexpression increased lipid accumulation primary...
LncRNAs are involved in modulating the individual risk and severity of progression metabolic dysfunction-associated fatty liver disease (MASLD), but their precise roles remain largely unknown. This study aimed to investigate role lncRNA Snhg3 development MASLD, along with underlying mechanisms. In vitro vivo experiments revealed that is lipid metabolism steatosis. The result showed was significantly downregulated high-fat diet-induced obesity (DIO) mice. Notably, palmitic acid promoted...
LncRNAs are involved in modulating the individual risk and severity of progression metabolic dysfunction-associated fatty liver disease (MASLD), but their precise roles remain largely unknown. This study aimed to investigate role lncRNA Snhg3 development MASLD, along with underlying mechanisms. In vitro vivo experiments revealed that is lipid metabolism steatosis. The result showed was significantly downregulated high-fat diet-induced obesity (DIO) mice. Notably, palmitic acid promoted...
Abstract LncRNAs are involved in modulating the individual risk and severity of progression metabolic dysfunction-associated fatty liver disease (MASLD), but their precise roles remain largely unknown. This study aimed to investigate role lncRNA Snhg3 development MASLD, along with underlying mechanisms. The result showed that was significantly downregulated high-fat diet-induced obesity (DIO) mice. Notably, palmitic acid promoted expression overexpression increased lipid accumulation primary...
LncRNAs are involved in modulating the individual risk and severity of progression metabolic dysfunction-associated fatty liver disease (MASLD), but their precise roles remain largely unknown. This study aimed to investigate role lncRNA Snhg3 development MASLD, along with underlying mechanisms. In vitro vivo experiments revealed that is lipid metabolism steatosis. The result showed was significantly downregulated high-fat-induced obesity (DIO) mice. Notably, palmitic acid promoted expression...
Long noncoding RNAs (lncRNAs) are strongly associated with glucose homeostasis, but their roles remain largely unknown. In this study, the potential role of lncRNA-Snhg3 in metabolism was evaluated both vitro and vivo. Here, we found a positive relationship between Snhg3 hepatic glycogenesis. Glucose tolerance improved hepatocyte-specific knock-in (Snhg3-HKI) mice, while it worsened knockout (Snhg3-HKO) mice. Furthermore, glycogenesis had shown remarkable increase Snhg3-HKI mice reduction...