A5101151232- Cancer-related molecular mechanisms research
- Pituitary Gland Disorders and Treatments
- Liver Disease Diagnosis and Treatment
- Molecular Sensors and Ion Detection
- Protein Kinase Regulation and GTPase Signaling
- Colorectal Cancer Surgical Treatments
- RNA modifications and cancer
- Luminescence and Fluorescent Materials
- Melanoma and MAPK Pathways
- Protein Tyrosine Phosphatases
- PI3K/AKT/mTOR signaling in cancer
- Peroxisome Proliferator-Activated Receptors
- MicroRNA in disease regulation
- Lipid metabolism and disorders
- Adipose Tissue and Metabolism
- Adrenal and Paraganglionic Tumors
- Neuroendocrine Tumor Research Advances
- Analytical Chemistry and Sensors
- Natural product bioactivities and synthesis
- Fibromyalgia and Chronic Fatigue Syndrome Research
- COVID-19 Clinical Research Studies
- Musculoskeletal pain and rehabilitation
- Neuroblastoma Research and Treatments
- Urological Disorders and Treatments
- Myofascial pain diagnosis and treatment
Shanghai Jian Qiao University
2023-2025
Northwest Normal University
2013-2025
Ministry of Agriculture and Rural Affairs
2025
Henan Agricultural University
2025
Fuzhou Second Hospital
2025
Peking University People's Hospital
2021-2024
Shanxi Medical University
2009-2024
Ruijin Hospital
2018-2024
Foshan Hospital of TCM
2019-2024
Beijing Friendship Hospital
2017-2024
Mitogen-activated protein (MAP) kinase lies at the convergence of various extracellular ligand-mediated signaling pathways. It is activated by dual-specificity kinase, MAP or MEK. inactivation mediated dephosphorylation via specific phosphatases (MKPs). One MKP (MKP-1 (also known as 3CH134, Erp, CL100)) has been reported to be expressed in a wide range tissues and cells. We report identification second widely MKP, termed MKP-2, isolated from PC12 MKP-2 showed significant homology with MKP-1...
Aberrant expression of long noncoding RNA H19 has been associated with tumour progression, but the underlying molecular tumourigenesis mechanisms remain largely unknown. Here, we report that is frequently downregulated in human primary pituitary adenomas and negatively correlated progression. Consistently, upregulation inhibits cell proliferation vitro growth vivo. Importantly, uncover a function H19, which controls cell/tumour through inhibiting mTORC1 not mTORC2. Mechanistically, show...
Two major intracellular signals that regulate neuronal function are calcium and cAMP. In many cases, the actions of these two second messengers involve long term changes in gene expression. One well studied target both cAMP signaling is transcription factor cAMP-responsive element-binding protein (CREB). Multiple pathways have been shown to contribute regulation CREB-dependent transcription, including kinase A (PKA)- mitogen-activated (MAP) kinase/extracellular signal-regulated...
Abstract Hormones and growth factors regulate cell via the mitogen-activated protein (MAP) kinase cascade. Here we examine actions of hormone somatostatin on MAP cascade through one its two major receptor subtypes, 1 (SSTR1) stably expressed in CHO-K1 cells. Somatostatin antagonizes proliferative effects fibroblast factor CHO-SSTR1 cells SSTR1 receptor. However, these cells, robustly activates (also called extracellular signal regulated kinase; ERK) augments factor-stimulated ERK activity....
Induction of neuronal differentiation the rat pheochromocytoma cell line, PC12 cells, by nerve growth factor (NGF) requires activation mitogen-activatedprotein (MAP) kinase or extracellular signal-regulated (ERK). cAMP-dependent protein (protein A (PKA)) also can induce these cells. Like NGF, ability PKA to differentiate cells is associated with a sustained ERKs. Here we show that maximal ERK1 NGF PKA. Inhibitors partially blocked but had no effect on EGF. Inhibition reduced and cAMP, not...
Our previous study demonstrated that the expression of long noncoding RNA (lncRNA) H19 was frequently downregulated in human primary pituitary adenomas and negatively correlated with tumor progression. However, role exosomal lncRNA inhibition growth remains unclear.To investigate whether could be transported across cell membrane to exert its inhibitory effect on growth.Empty lentivirus GH3 cells or without overexpression were used establish a xenograft model. Isolated exosomes identified by...
R2R3-MYB transcription factors play important roles in the regulation of plant flavonoid metabolites. In current study, NtMYB3, a novel transcriptional factor isolated from Chinese narcissus (Narcissus tazetta L. var. chinensis), was functionally characterized. Phylogenetic analysis indicated that NtMYB3 belongs to AtMYB4-like clade, which includes repressor MYBs involved biosynthesis. Transient assays showed significantly reduced red pigmentation induced by potato anthocyanin activator...
Adenovirus E1A mediates its effects on cellular transformation and transcription by interacting with critical proteins involved in cell growth differentiation. The amino terminus of binds to CBP/p300 associated histone acetyltransferases such as P/CAF. carboxyl the carboxyl-terminal binding protein (CtBP), which associates deacetylases. We show that 12S can be acetylated p300 P/CAF map one acetylation sites Lys-239. This Lys residue is adjacent consensus CtBP motif, PXDLS. Mutation Lys-239...
// Lei Yu 1, * , Xuejun Gong 2, Sun 3 Hong Yao 1 Baoling Lu Liying Zhu Department of Infectious Disease, The Fourth Hospital Harbin Medical University, 150001, Heilongjiang, China 2 Biliary and Pancreatic Surgery, Xiangya Central South Changsha, 410008, Hunan, Ophthalmology, These authors contributed equally to this work Correspondence to: Li-Ying Zhu, e-mail: zlyhmu@126.com Yu, widedoor@sina.com Keywords: hepatocellular carcinoma, microRNA, miR-454, CHD5 Received: May 11,...
Pituitary neuroendocrine tumors (PitNETs) are common gland neoplasms demonstrating distinctive transcription factors. Although the role of immune cells in PitNETs has been widely recognized, precise immunological environment and its control over tumor poorly understood. The heterogeneity, spatial distribution, clinical significance macrophages were analyzed using single-cell RNA sequencing (scRNA-seq), bulk RNA-seq, transcriptomics, immunohistochemistry, multiplexed quantitative...
In addition to regulating blood pressure and body fluid homeostasis, the renin-angiotensin system is also involved in lung fibrogenesis.To study effect of losartan, an angiotensin II antagonist, on bleomycin-induced pulmonary fibrosis rats its possible mechanism.Pulmonary was induced SD by intratracheal instillation bleomycin (5 mg x kg(-1)). Subsequently, received daily losartan (3, 9 27 kg(-1)) or prednisone (20 orally. Six each group were sacrificed 14 21 days after instillation....
Gefitinib is one of commonly used first-line treatment options for patients with positive EGFR mutation in non-small cell lung cancer (NSCLC). However, most gefitinib relapse over time due to the loss drug sensitivity. Compound Kushen injection (CKI) has been treat cancer, including EGFR-mutated NSCLC. In this report, we examined anti-cancer and sensitivity increased activities CKI less sensitive NSCLC lines H1650 H1975. Bioinformatics analysis was applied uncover gene regulation molecular...
Abstract Background Pituitary neuroendocrine tumors (PitNETs) are common intracranial that classified into seven histological subtypes, including lactotroph, somatotroph, corticotroph, thyrotroph, gonadotroph, null cell, and plurihormonal PitNETs. However, the molecular characteristics of these types PitNETs not completely clear. Methods A total 180 consecutive cases were collected to perform RNA sequencing. All subtypes distinguished by unsupervised clustering analysis. We investigated...
This study was designed to determine the molecular function of miR-141 and underlying mechanisms in colorectal cancer (CRC).SW480 cells which up- or down-regulated were established. Reverse transcription, quantitative polymerase chain reaction Western blotting used examine microRNA protein expression. Cell-cycle progression analyzed by flow cytometry. Proliferation marker Ki-67 evaluated immunofluorescence. Transwell assay conducted migration rates cells. Subcutaneous xenograft models effect...
Chinese poetry, renowned for its elegance and simplicity, is a hallmark of culture. While neural networks have made significant advancements in generating balancing diversity with adherence to rigid structural formats remains challenge. Research indicates that factors such as themes, emotions (e.g., happiness, sadness), sentiments positive, negative) play crucial role poetic creation, influencing both the quality generated content.In this paper, we propose MixSong, an autoregressive language...