A5109766691- Lung Cancer Research Studies
- Peptidase Inhibition and Analysis
- Colorectal Cancer Screening and Detection
- Cancer Mechanisms and Therapy
- Metabolism, Diabetes, and Cancer
- Colorectal and Anal Carcinomas
- Cosmology and Gravitation Theories
- Stellar, planetary, and galactic studies
- Cancer Immunotherapy and Biomarkers
- Dark Matter and Cosmic Phenomena
- Petroleum Processing and Analysis
- Urban Heat Island Mitigation
- AI in cancer detection
- Urban Green Space and Health
- Single-cell and spatial transcriptomics
- Diabetes Treatment and Management
- Renal Diseases and Glomerulopathies
- Traditional Chinese Medicine Studies
- Protein Degradation and Inhibitors
- Land Use and Ecosystem Services
- Lung Cancer Treatments and Mutations
- Thermochemical Biomass Conversion Processes
- Vasculitis and related conditions
- S100 Proteins and Annexins
- Gastric Cancer Management and Outcomes
Anhui Normal University
2025
Chinese Academy of Fishery Sciences
2025
Chinese PLA General Hospital
2023-2024
Suzhou Science and Technology Bureau
2024
Fudan University
2022-2024
Zhejiang University
2022-2024
Shanghai Chest Hospital
2022-2024
Shanghai Jiao Tong University
2023-2024
Beckman Research Institute
2024
Zhongshan Hospital
2024
Glioblastoma (GBM) is an aggressive malignant primary brain cancer with poor survival. Hypoxia a hallmark of GBM, which promotes tumor cells spreading (invasion) into the healthy tissue.
Pituitary neuroendocrine tumors (PitNETs) are common gland neoplasms demonstrating distinctive transcription factors. Although the role of immune cells in PitNETs has been widely recognized, precise immunological environment and its control over tumor poorly understood. The heterogeneity, spatial distribution, clinical significance macrophages were analyzed using single-cell RNA sequencing (scRNA-seq), bulk RNA-seq, transcriptomics, immunohistochemistry, multiplexed quantitative...
Abstract To overcome current limitations in photoimmunotherapy, such as insufficient tumor antigen generation and a subdued immune response, novel photo‐/metallo dual‐mode immunotherapeutic agent (PMIA) is introduced for potent near‐infrared (NIR) light‐triggered cancer therapy. PMIA features dumbbell‐like AuPt heterostructure decorated with starry Pt nanoclusters, meticulously engineered enhancing plasmonic catalysis through multi‐dimensional regulation of growth on Au nanorods. Under NIR...
Carotenoids are important natural pigments and have medical health functions for humans. Carotenoid cleavage dioxygenase 4 (
Richter’s transformation (RT) is a progression of chronic lymphocytic leukemia (CLL) to aggressive lymphoma. MGA ( Max gene associated ), functional MYC suppressor, mutated at 3% in CLL and 36% RT. However, genetic models molecular mechanisms deletion that drive RT remain elusive. We established an mouse model by knockout Mga the Sf3b1 / Mdr using CRISPR-Cas9 determine role Murine cells exhibited mitochondrial aberrations with elevated oxidative phosphorylation (OXPHOS). Through RNA...
We propose a novel mechanism for photon–dark photon mass-state oscillations mediated by gravitational separation during propagation through the interstellar medium. This phenomenon establishes new avenue detection of dark matter. By analyzing lensing data from quasars, we investigate sensitivity this approach to photons. Our analysis demonstrates constraints ε<10−2 in mass range 1.7×10−14 eV 5.4×10−14 eV. Furthermore, potential applications astrophysical systems with strong fields, such...
Urban greening plays a crucial role in maintaining environmental sustainability and enhancing people's well-being. However, limited by the shortcomings of traditional methods, studying heterogeneity nonlinearity between factors green view index (GVI) still faces many challenges. To address concerns nonlinearity, spatial heterogeneity, interpretability, an interpretable machine learning framework incorporating Geographically Weighted Random Forest (GWRF) model SHapley Additive exPlanation...
Abstract Background Hepatocellular carcinoma (HCC) is one of the most common human cancers with poor prognosis in world. HCC has become second leading cause cancer-related death China. It urgent to identify novel biomarker and valid target effectively diagnose, treat or predict HCC. been reported that S100A family closely related cell proliferation migration different cancers. However, values S100As remain be further analyzed. Methods We investigated transcriptional translational expression...
<title>Abstract</title> Urban greening plays a crucial role in maintaining environmental sustainability and enhancing people's well-being. However, limited by the shortcomings of traditional methods, studying heterogeneity nonlinearity between factors green view index (GVI) still faces many challenges. To address concerns nonlinearity, spatial heterogeneity, interpretability, an interpretable machine learning framework incorporating Geographically Weighted Random Forest (GWRF) model SHapley...
TRIM16 has been identified as a tumor suppressor in hepatocellular carcinoma (HCC). This study aimed to investigate whether there are genetic variants influencing HCC risk and/or prognosis and explore the mechanisms. We performed gene-wide single-nucleotide polymorphism (SNP) mining TRIM16. The associations of SNPs with both were assessed through two independent cohorts respectively. Functional experiments underlying A missense variant rs2074890 (G > T, resulting an amino acid substitution...
Objective: Ultrasound-guided fine-needle aspiration biopsy (US-FNAB) is a safe and effective method for screening malignant thyroid nodules. The purpose of this study was to compare the diagnostic effectiveness US-FNAB nodules different sizes. Methods: A total 1085 patients with who underwent between January 2021 July 2023 were included in study. divided into three groups based on maximum diameter nodules: there 324 ≤ 5 mm Group A, 537 6 10 B, 224 > C. satisfactory specimen rate, time...
Motor learning (ML), which plays a fundamental role in growth and physical rehabilitation, involves different stages of memory processes through brain regions. However, the neural mechanisms that underlie ML are not sufficiently understood. Here, previously unreported neuronal projection from dorsal hippocampus (dHPC) to zona incerta (ZI) involved regulation behaviors is identified. Using recombinant adeno-associated virus, projections ZI surprisingly identified as originating dentate gyrus...
Abstract Background The 9th edition of the TNM Classification for lung cancer delineates M1c into two subcategories: M1c1 (Multiple extrathoracic lesions within a single organ system) and M1c2 involving multiple systems). Existing research indicates that patients with in stage exhibit superior overall survival compared to those M1c2. primary frontline therapy advanced non‐small cell (NSCLC), lacking driver gene mutations, involves use immune checkpoint inhibitors (ICIs) combined...
We investigated association between skin adverse events (AEs) and efficacy with dacomitinib in patients
Background: Periodontits (PD) and Alzheimer's disease (AD) are both associated with ageing clinical studies increasingly evidence their association. However, specific mechanisms underlying this association remain undeciphered, immune-related processes purported to play a signifcant role. The accrual of publicly available transcriptomic datasets permits secondary analysis the application data-mining bioinformatic tools for biological discovery. Aim: present study aimed leverage databases,...
Durvalumab is a check-point inhibitor against programmed death ligand-1 (PD-L1), and anlotinib new orally administered multitarget tyrosine kinase (TKI). Both agents have been approved in China. Preclinical clinical trials suggested that antiangiogenic therapy has the potential to alleviate immunosuppression showed synergetic effect when combined with ICIs. However, it unclear whether this combination effective initiated as maintenance treatment ES-SCLC patients.This multicenter, randomized,...