A5100621779- Genomics and Phylogenetic Studies
- Ferroptosis and cancer prognosis
- Neurobiology and Insect Physiology Research
- RNA modifications and cancer
- CRISPR and Genetic Engineering
- Cancer Mechanisms and Therapy
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Chromosomal and Genetic Variations
- Genetic diversity and population structure
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- Invertebrate Immune Response Mechanisms
- Immune cells in cancer
- RNA Interference and Gene Delivery
- TGF-β signaling in diseases
- Crustacean biology and ecology
- Photosynthetic Processes and Mechanisms
- Cancer Cells and Metastasis
- S100 Proteins and Annexins
- Biochemical Analysis and Sensing Techniques
- Angiogenesis and VEGF in Cancer
- Pluripotent Stem Cells Research
- Insect Resistance and Genetics
Fujian Agriculture and Forestry University
2021-2025
Ruijin Hospital
2010-2025
Shanghai Jiao Tong University
2019-2025
Huazhong University of Science and Technology
2019-2025
Inner Mongolia University
2022-2023
Guangzhou Medical University
2023
Stomatology Hospital
2023
Hunan Normal University
2023
Zhejiang Wanli University
2022
Guangdong Medical College
2013-2022
To better determine the history of modern birds, we performed a genome-scale phylogenetic analysis 48 species representing all orders Neoaves using phylogenomic methods created to handle data. We recovered highly resolved tree that confirms previously controversial sister or close relationships. identified first divergence in Neoaves, two groups named Passerea and Columbea, independent lineages diverse convergently evolved land water bird species. Among Passerea, infer common ancestor core...
Using next-generation sequencing technology alone, we have successfully generated and assembled a draft sequence of the giant panda genome. The contigs (2.25 gigabases (Gb)) cover approximately 94% whole genome, remaining gaps (0.05 Gb) seem to contain carnivore-specific repeats tandem repeats. Comparisons with dog human showed that genome has lower divergence rate. assessment genes potentially underlying some its unique traits indicated bamboo diet might be more dependent on gut microbiome...
The cynomolgus and Chinese rhesus macaques are used as animal models in biomedical research. Yan et al. sequence their genomes compare the sequences to that of Indian macaque, providing a genetic foundation for interpreting research results. nonhuman primates most commonly medical from genus Macaca1. To better understand differences between these models, we present high-quality draft genome two macaque species, cynomolgus/crab-eating macaque. Comparison with previously sequenced reveals all...
BackgroundPenguins are flightless aquatic birds widely distributed in the Southern Hemisphere. The distinctive morphological and physiological features of penguins allow them to live an life, some have successfully adapted hostile environments Antarctica. To study phylogenetic population history molecular basis their adaptations Antarctica, we sequenced genomes two Antarctic dwelling penguin species, Adélie [Pygoscelis adeliae] emperor [Aptenodytes forsteri].
Parrots belong to a group of behaviorally advanced vertebrates and have an ability vocal learning relative other vocal-learning birds. They can imitate human speech, synchronize their body movements rhythmic beat, understand complex concepts referential meaning sounds. However, little is known about the genetics these traits. Elucidating genetic bases would require whole genome sequencing robust assembly parrot genome.We present genomic resource for budgerigar, Australian Parakeet...
During exogenous bone-graft-mediated bone defect repair, macrophage inflammation dictates angiogenesis and regeneration. Exosomes from different human cells have shown immunomodulation-mediated regeneration potential. However, the effect of serum-derived exosomes (serum-Exo) on during repair has not been investigated yet. In this study, we explored effects serum-Exo regulation-mediated preliminarily elucidated mechanism. Healthy was isolated by ultracentrifugation. The LPS-induced M1...
The freshwater prawn Macrobrachium rosenbergii is one kind of important economic aquaculture species and displays remarkable sexual dimorphism. molecular mechanism differentiation in M. has been primarily unraveled through the research efforts androgenic gland its related genes. However, understanding conserved genes involved underpinning sex determination still fragmentary. MroDmrt11E a member doublesex mab-3-related transcription factor (Dmrt) gene family prominently expressed testis. In...
The gene-drive system can ensure that desirable traits are transmitted to the progeny more than normal Mendelian segregation. clustered regularly interspersed palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) mediated has been demonstrated in dipteran insect species, including Drosophila and Anopheles, not yet other species. Here, we have developed a single CRISPR/Cas9-mediated construct for Plutella xylostella, highly-destructive lepidopteran pest of cruciferous crops. was...
Osteoarthritis (OA) is a chronic and degenerative disease marked by inflammation extracellular matrix (ECM) degeneration, contributing to synovial cartilage destruction. Accumulating evidence has demonstrated that Liver receptor homolog-1 (LRH-1), an orphan nuclear receptor, mediates inflammatory response. However, there lack of regarding the regulatory role LRH-1 in OA pathogenesis. In this study, we confirmed chondrocytes expressed LRH-1, observed its upregulation both IL-1β-treated...
Aim: To explore the potential functions and mechanism of N6.methyladenosine (m6A) abnormality RNAs in nucleus pulposus from intervertebral disc degeneration (IDD). Materials & methods: We performed rat model, m6A epitranscriptomic microarray, bioinformatics analysis metabolomics. Results: In IDD, most differentially methylated showed a significant demethylation situation. The competing endogenous RNA network LOC102555094/miR-431/GSK-3β combining downstream Wnt pathway were identified...
The pluripotent stem cells exist in a narrow window during early development and its derivation depends on intrinsic extrinsic growth signalling vitro. It has remained challenging to derive two or three distinct cell lines that are representative of blastocyst-stage lineages from one preimplantation embryo simultaneously chemical defined condition. Therefore, it is desirable establish system by manipulating culture multiple types single blastocyst. This study used medium containing Activin...
Osteoporosis is a result of impaired bone formation and/or excessive resorption. Osteoclasts are the only cells in body that have resorption function. Inhibiting osteoclast activity and differentiation way to treat osteoporosis. The current pharmacological treatment for osteoporosis has many shortcomings, more effective treatments needed. Vinpocetine (Vinp), derivative alkaloid vincamine, been used cerebrovascular disorders cognitive impairment long time. Vinp inhibits mitogen-activated...
Colorectal cancer (CRC) is the leading cause of cancer-related mortality in world. Accumulating evidence indicate that tumour infiltrating immune cells participated progression. Among them, neutrophils (TINs) are reported to play crucial role various cancers. In this study, we used CIBERSORTx, a digital cytometry tool evaluate infiltration CRC based on gene expression data tissues from GSE39582 set and The Cancer Genome Atlas (TCGA-COAD TCGA-READ). Weighted co-expression network analysis...
DsRNA-degrading enzymes (dsRNases) have been recognized as important factors in reducing RNA interference (RNAi) efficiency different insect species. However, dsRNases Plutella xylostella are still unknown. We identified the full-length cDNAs of PxdsRNase1, PxdsRNase2, PxdsRNase3, and PxdsRNase4. Gene expression profile showed that PxdsRNase1 was mainly expressed hemolymph; PxdsRNase2 PxdsRNase3 were intestinal tract. The PxCht (Chitinase P. xylostella) larvae injected with mixture dsPxCht...
Abstract Background Hepatocellular carcinoma (HCC) is one of the most common human cancers with poor prognosis in world. HCC has become second leading cause cancer-related death China. It urgent to identify novel biomarker and valid target effectively diagnose, treat or predict HCC. been reported that S100A family closely related cell proliferation migration different cancers. However, values S100As remain be further analyzed. Methods We investigated transcriptional translational expression...
The N-myc downstream-regulated gene (NDRG) family, NDRG1-4, has been involved in a wide spectrum of biological functions multiple cancers. However, their prognostic values remain sparse gastric cancer (GC). Therefore, it is crucial to systematically investigate the NDRG family GC.The were evaluated by Kaplan-Meier Plotter and SurvExpress. mRNA was investigated Cancer Genome Atlas (TCGA). Transcription factors (TFs) miRNAs associated with predicted NetworkAnalysis. DNA methylation levels...