A5065154015- Advanced battery technologies research
- SARS-CoV-2 and COVID-19 Research
- Perovskite Materials and Applications
- Cancer-related molecular mechanisms research
- Advanced Battery Materials and Technologies
- Genomics and Phylogenetic Studies
- Circular RNAs in diseases
- Adipose Tissue and Metabolism
- Chronic Lymphocytic Leukemia Research
- MicroRNA in disease regulation
- Animal Virus Infections Studies
- Pancreatic function and diabetes
- Bacteriophages and microbial interactions
- Metabolism, Diabetes, and Cancer
- Lymphoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Molecular Biology Techniques and Applications
- RNA modifications and cancer
- Animal Behavior and Reproduction
- Supercapacitor Materials and Fabrication
- Bioinformatics and Genomic Networks
- Plant Virus Research Studies
- Regulation of Appetite and Obesity
- Genetic diversity and population structure
- Primate Behavior and Ecology
Guangzhou Medical University
2023-2025
Kingmed Diagnostics
2022-2025
Fudan University
2022-2025
State Key Laboratory of Genetic Engineering
2025
Zhejiang University
2025
University of Washington
2024
Seattle University
2024
Clean Energy (United States)
2024
South China University of Technology
2012-2021
Regenerative Medicine Institute
2020
The cynomolgus and Chinese rhesus macaques are used as animal models in biomedical research. Yan et al. sequence their genomes compare the sequences to that of Indian macaque, providing a genetic foundation for interpreting research results. nonhuman primates most commonly medical from genus Macaca1. To better understand differences between these models, we present high-quality draft genome two macaque species, cynomolgus/crab-eating macaque. Comparison with previously sequenced reveals all...
Abstract The development and innovation of next generation sequencing (NGS) the subsequent analysis tools have gain popularity in scientific researches clinical diagnostic applications. Hence, a systematic comparison platforms variant calling pipelines could provide significant guidance to NGS-based genomics. In this study, we compared performance, concordance operating efficiency 27 combinations pipelines, testing three pipelines—Genome Analysis Tool Kit HaplotypeCaller, Strelka2...
The anode-free design is a promising strategy to increase the energy density of aqueous Zn metal batteries (AZMBs). However, scarcity Zn-rich cathodes and rapid loss limited greatly hinder their commercial applications. To address these issues, novel Zn-iodine battery (AFZIB) was designed via simple, low-cost scalable approach. Iodine plays bifunctional roles in improving AFZIB overall performance: enabling high-performance cathode modulating deposition behavior. On side, ZnI2 serves as...
First machine learning predictions of perovskite solar cell service lifetimes.
Type 2 Diabetes Mellitus (T2DM) and obesity have become increasingly prevalent in recent years. Recent studies focused on identifying causal variations or candidate genes for T2DM via analysis of expression quantitative trait loci (eQTL) within a single tissue. are affected by comprehensive sets multiple tissues. In the current study, gene levels human tissues from GEO datasets were analyzed, 21 displaying high percentages differential filtered out. Specifically, DENND1B, LYN, MRPL30, POC1B,...
To further reveal the phylogenetic evolution and molecular characteristics of whole genome severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) based on a large number genomes provide basis for prevention treatment SARS-CoV-2.Various analysis methods were employed.The estimated ratio rates non-synonymous to synonymous changes (Ka/Ks) SARS-CoV-2 was 1.008 or 1.094 622 3624 nine key specific sites high linkage, four major haplotypes found: H1, H2, H3 H4. The results Ka/Ks, detected...
The scarcity of lithium resources and the unsafety organic electrolytes limit further application lithium-ion batteries (LIBs) in electric vehicles grid-scale energy storage. Aqueous zinc-ion (AZIBs) are potential complements for LIBs large-scale grid storage because their abundant resources, environmental friendliness, intrinsic safety low cost. However, current AZIBs mainly based on intercalation-type cathodes densities not competitive with LIBs. Fortunately, conversion-type cathodes,...
Accumulating evidences demonstrated that microRNA-target gene pairs were closely related to tumorigenesis and development. However, the correlation between miRNA target was insufficiently understood, especially its changes tumor normal tissues.
ABSTRACT The pathogenicity of cholestatic liver diseases (CLDs) remains insufficiently characterized, hindering definitive diagnosis and timely treatment. aim this study was to improve the prediction novel bile acid (BA) transporter variants in patients with CLDs. We analyzed clinical characteristics genetic profiles a CLD cohort ( n = 57) using multiple silico tools vitro functional assays. identified 78 unique four BA genes. predominant defects were associated ABCC2 (57/78, 73.1%), most...
Background Increasing evidence indicates a robust correlation between epilepsy and variants of the Kv7.2 ( KCNQ2 ) channel, which is critically involved in directing M-currents regulating neuronal excitability within nervous system. With advancement next-generation sequencing, identification has surged. Nonetheless, their functional impacts are still being determined, introducing uncertainty into diagnostic process for affected families potentially hindering ability to participate targeted...
Within-host evolution plays a critical role in shaping the diversity of SARS-CoV-2. However, understanding primary factors contributing to prevalence intra-host single nucleotide variants (iSNVs) viral population remains elusive. Here, we conducted comprehensive analysis over 556,000 SARS-CoV-2 sequencing data and different S protein amino acid mutations elucidate key influencing iSNVs gene. revealed presence mutational hotspots within gene, mainly located NTD, RBD, TM, CT domains....
Abstract Objective Ephrin type‐B receptor 1 (EphB1) is a tyrosine kinase involved in axon guidance, synaptic plasticity, and tumorigenesis. However, the role of EphB1 metabolic regulation obesity remains poorly understood. This study aims to uncover energy metabolism provide insights into underlying mechanisms by which regulates obesity. Methods Two Ephb1 mutations identified from forward genetic screen for obesity‐related loci mice were examined their effects gene expression, metabolism,...
Non-human primates have emerged as an important resource for the study of human disease and evolution. The characterization genomic variation between within non-human primate species could advance development genetically defined models. However, specific reagents that would expedite such research, exon-capture tools, are lacking. We evaluated efficiency using a exome capture design selective enrichment exonic regions primates. compared exon sequence recovery in nine chimpanzees, two...
Abstract Breast cancer, the most common cancer in women worldwide, is associated with high mortality. The long non‐coding RNAs (lncRNAs) a little capacity of coding proteins playing an increasingly important role paradigm. Accumulating evidences demonstrate that lncRNAs have crucial connections breast prognosis while studies are still its primary stage. In this study, we collected 1052 clinical patient samples, comparatively large sample size, including 13 159 lncRNA expression profiles...
Type 2 diabetes (T2D) is a prevalent disease that happens around the world and usually with insulin resistance. MicroRNAs (miRNAs) represented important roles in suppression of gene expression were proven to be related human diseases. In this study, we used cynomolgus monkey fed normal high fatty diet (HFD), respectively, analyze miRNA profile whole blood by deep sequencing. Finally total 24 miRNAs differential filtered. Among them, miR-182 resistance modulating FOXO1 PI3K/AKT cascade had...
The Goto-Kakizaki (GK) rat is an animal model of non-obese type 2 diabetes (T2D). GK was generated through the introduction various genetic mutations from continuous inbreeding; these rats develop spontaneously. mutated genes in may play key roles regulation diabetes. hypothalamus plays a central role systematic energy homeostasis. Here, hypothalamic transcriptomes and Wistar at 4, 8 12 weeks were investigated by RNA-seq, multiple variants gene expression profiles obtained. number identified...
Abstract Objectives To reveal epidemic trend and possible origins of SARS-CoV-2 by exploring its evolution molecular characteristics based on a large number genomes since it has infected millions people spread quickly all over the world. Methods Various analysis methods were employed. Results The estimated Ka/Ks ratio is 1.008 or 1.094 622 3624 genomes, time to most recent common ancestor (tMRCA) was inferred in late September 2019. Further 9 key specific sites highly linkage four major...
Physical activity exerts positive effects on glycemic control in type 2 diabetes (T2D), which is mediated part by extensive metabolic and molecular remodeling of skeletal muscle response to exercise, while many regulators remain unclear. In the present study, we investigated acute exercise transcriptomic responses Goto-Kakizaki (GK) rats can spontaneously develop T2D. The transcriptomes from both 8-week-old GK Wistar that underwent a single session (60 min running using an animal treadmill...