A5057823709- Bone Tissue Engineering Materials
- Mesenchymal stem cell research
- Orthopedic Infections and Treatments
- 3D Printing in Biomedical Research
- Bone and Joint Diseases
- Dental Implant Techniques and Outcomes
- Electrospun Nanofibers in Biomedical Applications
- Cell Adhesion Molecules Research
- NF-κB Signaling Pathways
- Pediatric Hepatobiliary Diseases and Treatments
- Neonatal Health and Biochemistry
- Angiogenesis and VEGF in Cancer
- Endoplasmic Reticulum Stress and Disease
- Cardiac electrophysiology and arrhythmias
- Circular RNAs in diseases
- Supramolecular Self-Assembly in Materials
- Periodontal Regeneration and Treatments
- Immune Response and Inflammation
- Caveolin-1 and cellular processes
- Liver Disease Diagnosis and Treatment
- Infant Nutrition and Health
- Infectious Diseases and Tuberculosis
- Bone and Dental Protein Studies
- Ubiquitin and proteasome pathways
- Neonatal Respiratory Health Research
Harbin Medical University
2023-2025
Second Affiliated Hospital of Harbin Medical University
2023-2025
Zhujiang Hospital
2020-2024
Southern Medical University
2020-2024
Nanfang Hospital
2024
Fourth Affiliated Hospital of Harbin Medical University
2023
Abstract Steroid-induced osteonecrosis of the femoral head (ONFH) is characterized by decreased osteogenesis, angiogenesis, and increased adipogenesis. While bone tissue engineering has been widely investigated to treat ONFH, its therapeutic effects remain unsatisfactory. Therefore, further studies are required determine optimal angiogenesis adipogenesis in necrotic area head. In our study, we developed a carboxymethyl chitosan/alginate/bone marrow mesenchymal stem cell/endothelial...
CaO<sub>2</sub>/gelatin microspheres can slowly release oxygen to support cell survival in extreme hypoxia condition and enhance osteogenesis angiogenesis the necrotic femoral head after being grafted with 3D scaffold BMSCs.
Fabricate a MgO<sub>2</sub>-contained scaffold by 3D printing to improve ischemia and hypoxia in bone defect area.
The hypoxic microenvironment in osteosarcoma inevitably compromises the antitumor effect and local bone defect repair, suggesting an urgent need for sustained oxygenation tumor. currently reported oxygen-releasing materials have short cycles, harmful products, limited effects simply by improving hypoxia. Therefore, PCL/nHA/MgO2/PDA-integrated scaffold with a good photothermal therapy was innovatively constructed this work to achieve tumor cell killing regeneration functions simultaneously....
The combination of three-dimensional (3D) printed scaffold materials and various cytokines can achieve the purpose tissue reconstruction more efficiently. In this study, we prepared platelet-rich plasma (PRP)/gelatin microspheres combined with 3D polycaprolactone/β-tricalcium phosphate scaffolds to solve key problem that PRP cannot be released under control release time is too short, thus better promote bone repair. Consequently, composite displayed a good mechanical property sustained...
The repair of large bone defects remains a challenging problem in tissue engineering. Ischemia and hypoxia the defect area make it difficult for seed cells to survive differentiate, which fail perform effective regeneration. Current oxygen-producing materials frequently encounter problems such as rapid degradation rate, insufficient mechanical properties, molding, cumbersome fabrication. Here, novel three-dimensional (3D) printed integrated bionic oxygenated scaffold was fabricated with...
Implant-associated infections frequently complicate orthopedic surgeries, resulting in challenging issues. The current therapy of antibiotic treatment and surgical debridement often leads to drug resistance bone defect. development pH-responsive antimicrobial pro-osteogenic materials is a promising approach controlling repairing infected defects, especially given the weakly acidic pH bacterial infection area. Solid peroxides have potential provide sustained release hydrogen peroxide (H
ABSTRACT The pathogenicity of cholestatic liver diseases (CLDs) remains insufficiently characterized, hindering definitive diagnosis and timely treatment. aim this study was to improve the prediction novel bile acid (BA) transporter variants in patients with CLDs. We analyzed clinical characteristics genetic profiles a CLD cohort ( n = 57) using multiple silico tools vitro functional assays. identified 78 unique four BA genes. predominant defects were associated ABCC2 (57/78, 73.1%), most...
Background Increasing evidence indicates a robust correlation between epilepsy and variants of the Kv7.2 ( KCNQ2 ) channel, which is critically involved in directing M-currents regulating neuronal excitability within nervous system. With advancement next-generation sequencing, identification has surged. Nonetheless, their functional impacts are still being determined, introducing uncertainty into diagnostic process for affected families potentially hindering ability to participate targeted...
Bone defects caused by infection, tumor, trauma, and so on remain difficult to treat clinically. tissue engineering (BTE) has great application prospect in promoting bone defect repair. Polycaprolactone (PCL) is a commonly used material for creating BTE scaffolds. In addition, self-assembling peptides (SAPs) can function as the extracellular matrix promote osteogenesis angiogenesis. work, PCL scaffold was constructed 3D printing, then integrated with marrow mesenchymal stem cells (BMSCs)...
Vascular endothelial growth factor A (VEGFA), which plays a key role in angiogenesis, is composed of many isoforms. Distinct VEGFA isoforms are generated by alternative splicing mRNA and named as VEGFxxx, where xxx represents the number amino acids present final protein sequence. These have opponent pro- antiangiogenic effects. VEGF-Ax, an additional isoform containing 22-amino-acid extension COOH terminus, arising from mRNA, programmed translational readthrough. The function VEGF-Ax not...
A significant challenge in the tissue engineering of injured sites is lack vascularization engineered due to insufficient oxygen supply. scaffolding system required support seeded cells as develops. In this study, we examined effects hypoxic conditions and release on cell survival a synthetic system. We developed three-dimensional using CaO
Primary familial brain calcification (PFBC) is a rare neurodegenerative and neuropsychiatric disorder characterized by bilateral symmetric intracranial along the microvessels or inside neuronal cells in basal ganglia, thalamus, cerebellum. Slc20a2 homozygous (HO) knockout mice are most commonly used model to simulate phenotype observed human patients. However, cellular molecular mechanisms related calcification, particularly at early stage much prior emergence of remain largely unknown. In...
<title>Abstract</title> Bone loss is a significant complication of Staphylococcus aureus osteomyelitis, for which there currently no efficacious treatment despite research indicating the involvement various mechanisms in bone during infections. Oxeiptosis, caspase independent form cell death induced by oxidative stress, has been implicated pathogen elimination. Nevertheless, role oxeiptosis extinction osteoblasts S. infection remains uncertain. In current investigation, preliminary evidence...
To investigate the effects and related signaling pathway of miR-362-3p on OS.
目的 探讨外源性补充不同剂量的维生素D对极低出生体重儿(very low birth weight，VLBW)钙磷代谢状态的改善作用。 方法 120例VLBW分为大剂量组、小剂量组、对照组，各40例。三组VLBW均给予早产儿配方奶喂养及部分肠道外营养支持。在此基础上，大剂量组每天口服维生素D滴剂2粒(800 IU)，小剂量组每天口服维生素D滴剂1粒(400 IU)。均连续口服4周。比较三组出生后第1 d、第8 d、第15 d、第22 d、第36 d的血清钙、血清磷、血清25-羟维生素D水平，并记录补充维生素D期间的不良症状。 结果 对照组出生后第15 d的血清25-羟维生素D水平较出生后第1 d差异无统计学意义(P>0.05)；大剂量组与小剂量组出生后第15 d的血清25-羟维生素D均显著高于出生后第1 d，且高于对照组，差异有统计学意义(P 0.05)；大剂量组出生后第15 d的血清钙、血清磷水平显著高于出生后第1...