A5028002353- Bone Tissue Engineering Materials
- Spine and Intervertebral Disc Pathology
- Tissue Engineering and Regenerative Medicine
- Musculoskeletal pain and rehabilitation
- Mesenchymal stem cell research
- Periodontal Regeneration and Treatments
- Spinal Cord Injury Research
- Osteoarthritis Treatment and Mechanisms
- Orthopaedic implants and arthroplasty
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Neuroinflammation and Neurodegeneration Mechanisms
- Electrospun Nanofibers in Biomedical Applications
- Nerve injury and regeneration
- Graphene and Nanomaterials Applications
- Spinal Hematomas and Complications
- Bone and Joint Diseases
- Bone Metabolism and Diseases
- Bone health and treatments
- Extracellular vesicles in disease
- 3D Printing in Biomedical Research
- Circular RNAs in diseases
- Bone health and osteoporosis research
- Bone and Dental Protein Studies
- Liver Disease Diagnosis and Treatment
Zhujiang Hospital
2015-2025
Southern Medical University
2015-2025
Sixth Affiliated Hospital of Sun Yat-sen University
2024
Sun Yat-sen University
2024
Shanghai Jiao Tong University
2023
Sichuan University
2023
West China Hospital of Sichuan University
2023
Zhuhai People's Hospital
2012
Xian Yang Central Hospital
2012
Fourth People's Hospital of Changzhou
2012
Abstract Steroid-induced osteonecrosis of the femoral head (ONFH) is characterized by decreased osteogenesis, angiogenesis, and increased adipogenesis. While bone tissue engineering has been widely investigated to treat ONFH, its therapeutic effects remain unsatisfactory. Therefore, further studies are required determine optimal angiogenesis adipogenesis in necrotic area head. In our study, we developed a carboxymethyl chitosan/alginate/bone marrow mesenchymal stem cell/endothelial...
CaO<sub>2</sub>/gelatin microspheres can slowly release oxygen to support cell survival in extreme hypoxia condition and enhance osteogenesis angiogenesis the necrotic femoral head after being grafted with 3D scaffold BMSCs.
Fabricate a MgO<sub>2</sub>-contained scaffold by 3D printing to improve ischemia and hypoxia in bone defect area.
The hypoxic microenvironment in osteosarcoma inevitably compromises the antitumor effect and local bone defect repair, suggesting an urgent need for sustained oxygenation tumor. currently reported oxygen-releasing materials have short cycles, harmful products, limited effects simply by improving hypoxia. Therefore, PCL/nHA/MgO2/PDA-integrated scaffold with a good photothermal therapy was innovatively constructed this work to achieve tumor cell killing regeneration functions simultaneously....
Abstract Peripheral blood mesenchymal stem cells (PBMSCs) may be easily harvested from patients, permitting autologous grafts for bone tissue engineering in the future. However, PBMSC’s capabilities of survival, osteogenesis and production new matrix defect area are still unclear. Herein, PBMSCs were seeded into a nanofiber scaffold self-assembling peptide (SAP) cultured osteogenic medium. The results indicated SAP can serve as promising survival differentiation 3D conditions. Furthermore,...
Abstract Background Silent information regulator 6 (SIRT6) is a mammalian homolog of the nicotinamide adenine dinucleotide (NAD)-dependent deacetylase sirtuin family. Prior evidences suggested that anti-inflammatory function SIRT6 after spinal cord and brain injury, it plays crucial role in macrophages polarization adipose tissue skin. However, involved peripheral nerve injury still unknown. Given prominent recovery, we aim to investigate regulation phenotypes shift functions injury. Results...
Abstract Intervertebral disc degeneration (IVDD) is an aging disease that results in a low quality of life and heavy socioeconomic burden. The mitochondrial unfolded protein response (UPR mt ) take part various aging-related diseases. Our research intents to explore the role underlying mechanism UPR IVDD. Nucleus pulposus (NP) cells were exposed IL-1β nicotinamide riboside (NR) served as inducer treat NP cells. Detection ATP, NAD + NADH used determine function mitochondria. MRI, Safranin...
Spinal cord injury (SCI) is a severe disabling disease that characterized by inflammation and oxidative reactions. Tangeretin has been shown to possess significant antioxidant anti-inflammatory activities. The Keap1/Nrf2 pathway, downstream of the Sesn2 gene, involved in regulating response. main objective this study was investigate effect tangeretin on SCI its possible mechanism through cell animal models. A T9 clamp used for mouse model LPS-induced stimulation BV-2 cells model. improvement...
Hypertrophy of the ligamentum flavum (LF) is one key pathomechanisms lumbar spinal stenosis (LSS). Transforming growth factor (TGF)-β1 abundantly expressed in hypertrophied degenerative LF tissues from LSS. However, molecular mechanisms underling association between TGF-β1 and hypertrophy have not yet been fully elucidated. In this study, we investigated important role mitogen-activated protein kinase (MAPK) pathway pathogenesis LSS by analyzing expression connective tissue (CTGF)...
Purpose: Mesenchymal stem cells (MSCs) seeded on biocompatible scaffolds have therapeutic potential for bone defect repair. However, MSCs can be affected by hypoxia and nutritional deficiency due to a lack of blood vessels in the scaffolds. Here, we explored effects MSC differentiation clarify these mechanisms. Methods: Peripheral mesenchymal (PBMSCs) were cultured small individual chambers with oxygen concentrations 1%, 9%, 21%. Cell proliferation was evaluated Counting Kit 8 assays, cell...
The repair of large bone defects remains a challenging problem in tissue engineering. Ischemia and hypoxia the defect area make it difficult for seed cells to survive differentiate, which fail perform effective regeneration. Current oxygen-producing materials frequently encounter problems such as rapid degradation rate, insufficient mechanical properties, molding, cumbersome fabrication. Here, novel three-dimensional (3D) printed integrated bionic oxygenated scaffold was fabricated with...
The combination of three-dimensional (3D) printed scaffold materials and various cytokines can achieve the purpose tissue reconstruction more efficiently. In this study, we prepared platelet-rich plasma (PRP)/gelatin microspheres combined with 3D polycaprolactone/β-tricalcium phosphate scaffolds to solve key problem that PRP cannot be released under control release time is too short, thus better promote bone repair. Consequently, composite displayed a good mechanical property sustained...
Atractylenolide-III (AT-III) is well known as its role in antioxidant and anti-inflammatory. Present study was aimed to figure out effects on osteoarthritis potential mechanisms. Rat model, human cartilage explants rat/human chondrocyte cultures were prepared test AT-III's progression senescence. Potential targeted molecules of AT-III predicted using network pharmacology molecular docking, assessed by Western blotting then verified with rescue experiments. treatment alleviated severity...
Osteoporotic bone regeneration poses significant challenges due to the complexity of condition. Osteoporosis, a degenerative disorder, results from an imbalance in homeostasis driven by dysregulation osteoblast and osteoclast activity. This complicates treatment osteoporosis its related injuries clinical practice. Despite development various polymer scaffolds for defect repair, achieving effective osteoporotic bones-especially when combined with medications-remains difficult. In this study,...
Intervertebral disc degeneration (IVDD) is a core factor in spinal degeneration. To date, there no effective treatment for IVDD. It urgent to identify the pathogenesis of IVDD develop strategies treatment. Alleviating endplate chondrocyte promising strategy treatment, while mitophagy prevents chondrocytes. Stigmasterol (STM) protects neurons from injuries by triggering mitophagy, yet effect STM on chondrocytes has not been reported. In this study, was induced interleukin-1β, and ribonucleic...
Prostate cancer is a serious disease that can invade bone tissues. These metastases greatly decrease patient's quality of life, pose financial burden, and even result in death. In recent years, tumor cell-secreted microvesicles have been identified proposed to be key factor cell interaction. However, the impact cancer-derived exosomes on cells remains unclear. Herein, we isolated from prostate line PC-3 investigated their effects human osteoclast differentiation by tartrate-resistant acid...