A5100430894- Invertebrate Immune Response Mechanisms
- Insect symbiosis and bacterial influences
- Neurobiology and Insect Physiology Research
- Entomopathogenic Microorganisms in Pest Control
- Insect Resistance and Genetics
- Insect and Arachnid Ecology and Behavior
- Insect Utilization and Effects
- Animal Genetics and Reproduction
- Insect and Pesticide Research
- Immunotherapy and Immune Responses
- Insect-Plant Interactions and Control
- Immune Response and Inflammation
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- RNA Interference and Gene Delivery
- Mosquito-borne diseases and control
- Aquaculture Nutrition and Growth
- Aquaculture disease management and microbiota
- Antimicrobial Peptides and Activities
- RNA Research and Splicing
- Chromosomal and Genetic Variations
- Reproductive System and Pregnancy
- Inflammasome and immune disorders
- interferon and immune responses
- Atherosclerosis and Cardiovascular Diseases
- Reproductive biology and impacts on aquatic species
Central China Normal University
2015-2025
University of California, Riverside
2017-2025
Chengdu Sport University
2025
Jilin Agricultural University
2025
Hefei University of Technology
2024
Chinese Academy of Fishery Sciences
2024
Hainan University
2024
Nanfang Hospital
2023
Southern Medical University
2023
Capital Medical University
2021-2022
Female mosquitoes require a vertebrate blood meal to activate reproduction, transmitting numerous devastating human diseases. Vitellogenesis is central event of female reproduction that involves the massive production vitellogenin (Vg) in fat body and maturation ovaries. This process controlled by steroid hormone 20-hydroxyecdysone (20E); however, its molecular regulatory basis remains not completely understood. We found expression Aedes aegypti muscle aponeurosis fibromatosis B ( AaMafB ),...
Abstract Background The insect hemolymph (blood-equivalent fluid), composed of a large number hemocytes (blood cells) and variety soluble immune effectors, is hostile for pathogens including fungi. In order to survive in the hemocoel (body cavity), entomopathogenic fungus (EPF) has evolved two classical coping strategies, namely evasion suppression host reactions. However, it remains unclear whether EPF other ways with immunity. Results this study, we demonstrated that Metarhizium rileyi (an...
Abstract Background Wolbachia are endosymbiotic bacteria that frequently found in arthropods and nematodes. These maternally inherited manipulate host reproduction by several mechanisms including cytoplasmic incompatibility (CI). CI is the most common phenotype induced results developmental arrest of embryos derived from crosses between -infected males uninfected females. Although molecular currently unknown, studies suggest sperm modified during spermatogenesis. Results We compared gene...
Wolbachia are obligate endosymbiotic bacteria that infect numerous species of arthropods and nematodes. can induce several reproductive phenotypes in their insect hosts including feminization, male-killing, parthenogenesis cytoplasmic incompatibility (CI). CI is the most common phenotype occurs when Wolbachia-infected males mate with uninfected females resulting no or very low numbers viable offspring. However, matings between infected same strain result progeny. Despite substantial...
Abstract Background Recent studies identified an increased risk of prostate cancer (PCa) in Caucasian men harboring polymorphisms genes involved innate immunity and inflammation. This study was designed to assess whether single nucleotide the IL-10 promoter play a role predisposing individuals PCa Chinese population. Methods We genotyped three SNPs (-1082A/G, -819T/C -592A/C) using polymerase chain reaction-restriction fragment length polymorphism analysis 262 subjects with 270 age-matched...
To investigate the molecular mechanisms of cytoplasmic incompatibility (CI) induced by Wolbachia bacteria in Drosophila melanogaster, we applied an isobaric tags for relative and absolute quantitation (iTRAQ)-based quantitative proteomic assay to identify differentially expressed proteins extracted from spermathecae seminal receptacles (SSR) uninfected females mated with either 1-day-old Wolbachia-uninfected (1T) or infected males (1W) 5-day-old (5W). In total, 1317 were quantified; 83...
Purpose.: To enhance drug uptake in RPE cells, improve efficacy for choroidal neovascularization (CNV), and reduce toxicity, an EphA2-targeted nanocarrier loaded with doxorubicin (DOX) was developed by conjugation a homing peptide YSA. Methods.: The YSA coupled to PEGylated lipid. Then, YSA-modified DOX stealth liposomes (YSA-SSL-DOX) were prepared characterized. Their human cell line (ARPE-19) evaluated. After intravitreous injection, their against CNV assessed laser-induced rat model....
DBZ (Danshensu Bingpian Zhi), a synthetic derivative of natural compound found in traditional Chinese medicine, has been reported to suppress lipopolysaccharide-induced macrophage activation and lipid accumulation vitro. The aim this study was assess whether could attenuate atherosclerosis at early advanced stages.
The immune system of a host functions critically in shaping the composition microbiota, and some microbes are involved regulating endocrine development. However, whether acts on development by microbiota remains unclear, few molecular players or this process have been identified. In current study, we found that RNA interference C-type lectin (HaCTL3) cotton bollworm Helicoverpa armigera suppresses ecdysone juvenile hormone signaling, thus reducing larval body size delaying pupation....
Metarhizium rileyi is an entomopathogenic fungus with promising potential for controlling agricultural pests, including Spodoptera frugiperda. Following penetration of the host through cuticle, M. cells transform into in vivo blastospores or hyphal bodies, propagating within hemocoel. However, strategies and molecular mechanisms by which survives upon exposure to powerful insect immune system remain unclear.We determined pathogenicity found that either conidial immersion blastospore...
Abstract Background Gut bacteria are beneficial to the host, many of which must be passed on host offspring. During metamorphosis, midgut holometabolous insects undergoes histolysis and remodeling, thus risks losing gut bacteria. Strategies employed by minimize this risk obscure. How affect after entering hemocoel causing opportunistic infections remains largely elusive. Results We used Helicoverpa armigera as a model found low Lactobacillus load, high level C-type lectin (CTL) gene CD209...