A5102917191- Mercury impact and mitigation studies
- Animal Genetics and Reproduction
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Toxic Organic Pollutants Impact
- Epigenetics and DNA Methylation
- Effects and risks of endocrine disrupting chemicals
- Reproductive biology and impacts on aquatic species
- Cancer-related gene regulation
- Heavy metals in environment
- Aquaculture Nutrition and Growth
- Birth, Development, and Health
- Per- and polyfluoroalkyl substances research
- Marine animal studies overview
- Estrogen and related hormone effects
- Reproductive System and Pregnancy
- Semiconductor materials and devices
- Cancer-related molecular mechanisms research
- Environmental Toxicology and Ecotoxicology
- Advanced Photocatalysis Techniques
- Sexual Differentiation and Disorders
- Heavy Metal Exposure and Toxicity
- Sleep and related disorders
- Microplastics and Plastic Pollution
- Zebrafish Biomedical Research Applications
- MicroRNA in disease regulation
Sichuan University
2024-2025
Jianghan University
2017-2025
Beijing Tian Tan Hospital
2024
Guilin University of Electronic Technology
2016-2024
Capital Medical University
2024
Chinese Academy of Sciences
2004-2022
Research Center for Eco-Environmental Sciences
2017-2022
China Jiliang University
2022
Central China Normal University
2008-2021
Institute of Hydrobiology
2012-2018
There is growing concern about the distribution of nanoplastics (NPs) in central nervous system (CNS), whereas intrusion poorly understood. In this study, fluorescent-labeled polystyrene NPs (PS-NPs) were microinjected into different areas zebrafish embryo to mimic routes exposure. PS-NPs observed brain, eyes, and spinal cord through gametal It indicated that maternally derived specially distributed CNS during early development. Importantly, these stranded but not transferred other organs...
Growth and reproduction are closely related. hormone (GH)-transgenic common carp exhibit accelerated growth delayed reproductive development, which provides an amenable model to study cross talk between the axes. We analyzed energy status development in GH-transgenic by using multi-tissue RNA sequencing, real-time-PCR, Western blotting, ELISA, immunofluorescence, vitro incubation. The expression of gys (glycogen synthase) igfbp1 (insulin-like factor binding protein) as well blood glucose...
Abstract DMC1 is a recombinase that essential for meiotic synapsis. Experiments in extensive species of eukaryotes have indicated the independent role repairing double strand breaks (DSBs) produced during meiosis I. Mutation dmc1 mice and human often leads to obstacles spermatogenesis male sterility. Here, we report on disruption medaka ( Oryzias latipes ). Synapsis was disturbed mutant testis nuclei, as observed other organisms. Unexpectedly, could produce few sperm and, although most these...
Biomonitoring is an effective way to assess the effects of pollutants on marine ecosystems. As important fishing region in China, Chinese Bohai Sea has been contaminated with heavy metals, posing great risks seafood safety and human health. Herein, spatiotemporal variations concentrations seven metals (As, Cd, Cr, Cu, Ni, Pb, Zn) 11 species mollusks (658 samples) collected from were studied during 2006-2016. The As, Pb approximately 41%, 100%, 71%, 18% sampled exceeded maximum permissible...
Tris(2,3-dibromopropyl) isocyanurate (TBC), recognized as an endocrine disruptor, can cause inflammatory injury to the lung tissue of mice. To investigate specific respiratory effects TBC, male C57BL/6J mice were administered a daily dose 20 mg/kg TBC over 14 days. Postexposure, these developed chronic obstructive pulmonary disease (COPD)-like symptoms characterized by damage and functional impairment. In light antiestrogenic properties we administrated estradiol (E2) its potential...
Abstract Water‐solid contact electrification (CE) is a common physical phenomenon. The electron transfer during water‐solid CE can mediate the redox reactions at interface, however, effect of different surface functional groups on this physicochemical process and its mechanism are limited in understanding. Here, we have regulated caused by between water florine‐doped tin oxide (FTO) with various groups, as well their processes contact. It revealed that ‐COOH FTO sample has larger work...
Black phosphorus (BP), a novel two-dimensional (2D) material, has shown promising applications in the optoelectronic, biological, and medical fields recent years. However, its increasing use may lead to inadvertent environmental release, creating potential ecological health risks that remain poorly understood. In this study, wild-type transgenic zebrafish were used evaluate developmental toxicity of small-size BP (S-BP), with lateral particle size 154.4 ± 34.6 nm, focusing specifically on...
Abstract Medaka is an ideal model for sex determination and reversal, such as XY phenotypically female patients in humans. Here, we assembled improved TALENs targeting the DMY gene generated − mutants to investigate gonadal dysgenesis medaka. -TALENs resulted indel mutations at targeted loci (46.8%). DMY-nanos3UTR induced were passed through germline F1 generation with efficiencies of up 91.7%. developed into females, laid eggs stably Y chromosome next generation. RNA-seq 157 million raw...
The Vitreoscilla hemoglobin gene (VHb), trans-zeatin secretion (tzs), and the modified 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS), as linked expression cassettes, were simultaneously introduced into immature embryos of rice (Oryza sativa L.) cultivars Xiushui-11, Qiufeng, Youfeng, Hanfeng by Agrobacterium tumefaciens A total 1153 transgenic lines composed 4222 plants obtained through selection for hygromycin (hyg) B resistance. Genomic polymerase chain reaction (PCR), southern...
Heavy metal pollution elicits severe environmental concern and health problem worldwide. Mercury is considered as a ubiquitous pollutant due to its versatile application in medicine, industry, cosmetics. Long noncoding RNAs (lncRNAs) are transcripts greater than 200 nt without protein-encoding function. However, little known about the mechanism of heavy metals-induced RNA changes aquatic organisms. To reveal epigenetic mercury toxicity zebrafish embryos explore novel specific...