A5109297926- Crystallization and Solubility Studies
- DNA Repair Mechanisms
- X-ray Diffraction in Crystallography
- Multilevel Inverters and Converters
- Effects and risks of endocrine disrupting chemicals
- Microbial Metabolic Engineering and Bioproduction
- Plant Genetic and Mutation Studies
- Carcinogens and Genotoxicity Assessment
- Metabolomics and Mass Spectrometry Studies
- Biofuel production and bioconversion
- HVDC Systems and Fault Protection
- High-Voltage Power Transmission Systems
- Mitochondrial Function and Pathology
- Pancreatitis Pathology and Treatment
- Zebrafish Biomedical Research Applications
- Molecular Biology Techniques and Applications
- SARS-CoV-2 and COVID-19 Research
- Cancer, Hypoxia, and Metabolism
- Electric Motor Design and Analysis
- Epigenetics and DNA Methylation
- Microgrid Control and Optimization
- Toxic Organic Pollutants Impact
- Radiation Effects and Dosimetry
- Reproductive System and Pregnancy
- Virus-based gene therapy research
Guangdong Pharmaceutical University
2025
Chinese PLA General Hospital
2025
Westlake University
2025
Hangzhou First People's Hospital
2025
University of Chinese Academy of Sciences
2018-2024
Research Center for Eco-Environmental Sciences
2020-2024
Chinese Academy of Sciences
2017-2024
Institute of Microbiology
2023-2024
Northeast Electric Power University
2024
Tianjin University of Traditional Chinese Medicine
2024
Lysine methyltransferase KMT5C catalyzes deposition of trimethylation on histone H4 lysine 20 (H4K20me3), an epigenetic marker usually associated with gene repression and maintenance heterochromatin. is widely expressed in a variety tissues, however, its functional role liver has not been explored. Here, we show Kmt5c fasting- glucagon-induced which regulates hepatic gluconeogenesis. Loss hepatocytes results downregulated gluconeogenic expression compromised glucose output during fasting....
Abstract The recent outbreak of mpox epidemic, caused by monkeypox virus (MPXV), poses a new threat to global public health. Here, we initially assessed the preexisting antibody level MPXV B6 protein in vaccinia vaccinees born before end immunization program and then identified two monoclonal antibodies (MAbs), hMB621 hMB668, targeting distinct epitopes on B6, from one vaccinee. Binding assays demonstrate that both MAbs exhibit broad binding abilities its orthologs (VACV), variola (VARV)...
Hyperuricemia is characterized by elevated blood uric acid (UA) levels, which can lead to certain diseases. Epidemiological studies have explored the association between environmental contaminant exposure and hyperuricemia. However, few investigated role of chemical in development Here, we sought investigate effects bisphenol on occurrence Fifteen chemicals (BPs) were detected human serum urine samples collected from an area with a high incidence hyperuricemia China. Serum UA levels...
Background Etoposide is a cancer drug that induces strand breaks in cellular DNA by inhibiting topoisomerase II (topoII) religation of cleaved molecules. Although cleavage always produces II-linked double-strand (DSBs), the action etoposide also results single-strand (SSBs), since two strands are independently inhibited etoposide. In addition, recent studies indicate DSBs remain undetected unless removed to produce free DSBs. Methodology/Principal Findings To examine etoposide-induced damage...
Tetrabromobisphenol A (TBBPA), a ubiquitous environmental pollutant, has been implicated in developmental toxicity of aquatic animals. However, the impact TBBPA on development and related mechanism have not fully elucidated. In this study, using live imaging technique transgenic labeling zebrafish embryos, we described toxic effects hematopoietic zebrafish. We demonstrated that induced erythroid precursor expansion intermediate cell mass (ICM), which perturbed onset blood circulation at...
Abstract Sarcopenia is defined by age-related reductions in muscle mass, strength, and physiological function, it especially prevalent among individuals with autoimmune diseases. Autoimmune disorders, characterized immune dysregulation, cause systemic inflammation damage to multiple tissues through unregulated activity. Research indicates that diseases negatively impact skeletal functions may worsen the progression of sarcopenia. This viewpoint comprehensively discusses pathogenesis...
Severe acute pancreatitis (SAP) characterized by atrocious progression and numerous complications often leads to a high mortality rate due hypermetabolism, systemic inflammatory response syndrome (SIRS), multiple organs dysfunction (MODS). Studies have revealed that both early enteral nutrition (EEN) emodin are potent agents in the management of SAP. However, whether combined strategy is rational more effective than either one alone remains unknown. In this regard, Wistar rats were treated...
Abstract Most lung cancer (LC) patients are diagnosed at advanced stages due to the lack of effective screening tools. This multicenter study analyzes 1043 saliva samples (334 LC cases and 709 non‐LC cases) using a novel high‐throughput platform for metabolic fingerprint acquisition. Machine learning identifies 35 features distinguishing from subjects, enabling development classification model named SalivaMLD. In validation set test set, SalivaMLD demonstrates strong diagnostic performance,...
This paper for the first time comprehensively presents a multilevel space vector pulse width modulation (SVPWM) method based on imaginary coordinate system. is probably one of most efficient methods in fast SVPWMs. It avoids trigonometric operation, look-up tables and only requires simple logic judgement arithmetic calculation. A distinct advantage this over other coordinate-transformation-based that it does not need to transform from system back a-b-c (or α-β) order select redundant vectors...
Bisphenol S (BPS) is a bisphenol A (BPA) replacement that widely present in the environment and humans. The association between obesity BPS has been reported epidemiological studies; however, obesogenic effect related mechanism of remain poorly understood. In this study, high-resolution microcomputed tomography analysis showed volume visceral fat was significantly increased BPS-treated mice. Moreover, higher potency to induce formation mice than BPA at exposure concentration 5 mg/kg/day for...
Since the outbreak of COVID-19, many SARS-CoV-2-related coronaviruses (CoVs) have been discovered. Previous research identified a novel lineage CoVs in bat, such as RsYN04, which recognizes human angiotensin-converting enzyme 2 (ACE2) and poses potential threat to humans. Here, we screened binding RsYN04 receptor-binding domain (RBD) ACE2 orthologs from 52 animal species, found that virus shows narrower ACE2-binding spectrum than SARS-CoV-2. However, T484W mutation RBD can broaden spectrum....
Ionizing radiation (IR) can result in serious genomic instability and genotoxicity by causing DNA damage. Carbon ion (CI) beams X-rays are typical IRs possess high-linear energy transfer (LET) low-LET, respectively. In this article, a comet assay that was optimized decreasing the electrophoresis time (8 minutes) voltage (0.5 V/cm) performed to elucidate quantify damage induced CI or radiation. Two quantitative methods for assay, namely, score olive tail moment, were compared, appropriate...
Clostridium acetobutylicum ( C. ) has considerable potential for use in bioenergy development. Owing to the repeated of traditional mutagenesis methods, strains have developed a certain tolerance. The rheology bioprocess and downstream processing product heavily depend on ability mutants produce butanol. Carbon ion beam irradiation advantages over mutation methods fermentative production because its dose conformity superb biological effectiveness. However, effects specific productivity not...