A5023017024- Intraperitoneal and Appendiceal Malignancies
- Adrenal and Paraganglionic Tumors
- Antibiotic Resistance in Bacteria
- Pesticide and Herbicide Environmental Studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Bacterial Identification and Susceptibility Testing
- Weed Control and Herbicide Applications
- Hormonal Regulation and Hypertension
- Antibiotics Pharmacokinetics and Efficacy
- Environmental Toxicology and Ecotoxicology
- Antibiotic Use and Resistance
- Metabolomics and Mass Spectrometry Studies
- Pneumonia and Respiratory Infections
- Ferroptosis and cancer prognosis
- Advanced Chemical Sensor Technologies
- Cancer-related gene regulation
- Bladder and Urothelial Cancer Treatments
- Biocrusts and Microbial Ecology
- Cancer-related Molecular Pathways
- Immune cells in cancer
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Research Studies
- Infections and bacterial resistance
- Inflammasome and immune disorders
- Bacterial biofilms and quorum sensing
Nanchang University
2023-2025
Guangxi University
2023-2025
First Affiliated Hospital of Jiangxi Medical College
2024-2025
Tongde Hospital of Zhejiang Province
2025
Second Affiliated Hospital of Nanchang University
2023-2024
Zhejiang Chinese Medical University
2019-2022
Beijing University of Chemical Technology
2018
Flusulfinam, a novel chiral herbicide, effectively controls Echinochloa crusgalli and Digitaria sanguinalis in paddy fields, indicating significant potential for practical agricultural applications. However, limited information is available on flusulfinam from perspective. A comprehensive evaluation of the enantiomeric levels was performed.
Background:This retrospective study was designed to assess risk factors for increased 30-day mortality from bacteremia caused by Escherichia coli or Klebsiella pneumoniae and calculate the optimal point of time patients move inappropriate empirical antimicrobial therapy appropriate treatment. Material/Methods:This analyzed data 610 with a diagnosis E. coli-and K. pneumoniae-induced collected between 2020 2023, including population-based information, infection bacteria, comorbidities,...
Indole, a crucial bacterial signaling molecule, plays fundamental role in regulating various physiological processes within bacteria, including growth, acid tolerance, biofilm development, motility, and other cellular functions. Its regulatory influence extends beyond indole-producing significantly impacting the activities non-indole-producing species. In this study, we demonstrate that indole enhances pathogenicity viability of Klebsiella pneumoniae using Galleria mellonella infection model...
Introduction The tumor immune environment and immune-related genes are instrumental in the development, progression, prognosis of bladder cancer (BLCA). This study sought to pinpoint key influencing BLCA decipher their mechanisms action. Methods results We analyzed differentially expressed (DEGs) between high- low- mutational burden (TMB) groups. Subsequently, we constructed a reliable prognostic model based on gene pairs (IRGPs) DEGs low-risk A total 22 shared were identified across...
This study aimed to identify carbapenem-resistant Klebsiella pneumoniae (CRKP) based on changes in levels of its volatile organic compounds (VOCs) simulated blood cultures (BCs) using the gas chromatography-ion mobility spectrometry (GC-IMS) technique. A comprehensive analysis metabolites produced by (K. pneumoniae) BC bottles was conducted GC-IMS. Subsequently, released VOCs were analyzed examine differences VOC release between CRKP and carbapenem-susceptible (CSKP). total 54 detected,...
Objective: This research aimed to analyze the clinical characteristics, prognosis, and antimicrobial treatment of bloodstream infections (BSI) caused by Enterobacter cloacae complex (ECC). Methods: The data patients with from April 2017 June 2023 were collected retrospectively. These then analyzed in subgroups based on detection results extended-spectrum β-lactamase (ESBL), 30-day mortality, type agent used (β-lactam/β-lactamase inhibitor combinations (BLICs) or carbapenems). Results:...
ABSTRACT Bronchial stump fistula occurs at the site of a lobectomy or segmentectomy and is specific type bronchopleural fistula. In addition to complications such as empyema pneumothorax, large bronchial can result in decreased lung ventilation due significant air leakage, particularly during general anaesthesia with endotracheal intubation, making closure challenging. The present paper reports on case patient right who had difficulty maintaining normal oxygenation when using conventional...
Abstract Most lung cancer (LC) patients are diagnosed at advanced stages due to the lack of effective screening tools. This multicenter study analyzes 1043 saliva samples (334 LC cases and 709 non‐LC cases) using a novel high‐throughput platform for metabolic fingerprint acquisition. Machine learning identifies 35 features distinguishing from subjects, enabling development classification model named SalivaMLD. In validation set test set, SalivaMLD demonstrates strong diagnostic performance,...
Background and aim: A potent selective vascular endothelial growth factor receptor (VEGFR) inhibitor SU5416, has been developed for the treatment of solid human tumors. The binding VEGF to VEGFR plays a crucial role in pathophysiology respiratory disorders. However, impact SU5416 on lipopolysaccharide (LPS)-induced acute lung injury (ALI) remains unclear. Thus, this study aimed illuminate biofunction mouse model ALI. Methods: Wild-type (WT) toll-like 4 (TLR4)-deficient (TLR4 −/- ) C57BL/6...
Objective: This research aimed to investigate the variations in clinical features and prognosis of HABP caused by E. coli K. pneumoniae . We also evaluate risk variables related 30-day death investigated groups. Methods: A single-center retrospective cohort lasting four years was performed. total 117 patients with were involved this research. The primary death. Results: Among HABP, 60 infected (KP-HABP), 57 (E. coli-HABP). higher proportion males, ICU admission, undergoing tracheotomy...
Lactate and tumor cell-derived extracellular vesicles (TEVs) both contribute to progression. However, it is still unclear whether lactate can accelerate development by directly promoting TEV production. Here, we show that decreases intracellular cAMP levels subsequent PKA activation via GPR81, which inhibits the PKA-induced ubiquitination of HIF-1α causes degradation. Then, HIF-1α-mediated transcription Rab27a enhanced, leading increased release. In this way, promotes lung metastasis murine...
Objective: This study aimed to determine the clinical features, risk factors, and effective antimicrobial therapy for Carbapenem-resistant Acinetobacter baumannii (CRAB) bloodstream infection (BSI). Methods: was a retrospective analysis of data from patients with CRAB bacteremia in Chinese tertiary hospital between January 2012 October 2021. Risk predictors 30-day mortality, BSI were identified using logistic cox regression analyses. Results: Data 276 (AB) included, whom 157 (56.9%) had BSI....
To analyze the clinical characteristics, outcomes, and risk factors of patients treated with ceftazidime/avibactam, polymyxin, or tigecycline (CPT) compared those receiving a conventional therapy (CT) (ie, imipenem, levofloxacin, gentamicin).A single-center retrospective cohort study included carbapenem-resistant Klebsiella pneumoniae bloodstream infection (CRKP-BSI) at one Chinese tertiary hospital between March 2012 November 2022 was performed. Clinical CPT CT were compared. Predictors...
<h3>Objectives:</h3> To compare the prognosis of bacteremic pneumonia caused by <i>Klebsiella pneumoniae</i> (<i>K. pneumoniae</i>) and <i>Escherichia coli</i> (<i>E. coli</i>) pathogens. <h3>Methods:</h3> A retrospective analysis was carried out on clinical data 162 patients who were diagnosed with bacterial either <i>K. or <i>E. between 2016-2019. The primary outcome patients’ 30-day mortality rate. <h3>Results:</h3> There 82 in coli</i>-BP) group 80 (KP-BP) group. rate 43.75% (n=35/80)...
Background:This study aimed to detect the volatile organic compound (VOC), 3-hydroxy-2-butanone (acetoin) using gas chromatography-ion mobility spectrometry (GC-IMS) in antimicrobial-resistant Klebsiella pneumoniae (K.pneumoniae) carbapenemase (KPC)-producing bacteria. Material/Methods:Using stromal fluid of blood culture bottles (BacT/ALERT ® SA) as medium, released by K. during growth was detected GC-IMS.The impact imipenem (IPM) and inhibitors [avibactam sodium or...
Abstract Acquired resistance to osimertinib is inevitable and heterogeneous despite its documented efficacy against EGFR‐mutated non‐small cell lung cancer (NSCLC). Subsequent therapeutic options assume the dominant form of mechanism; however, more rare oncogenic driver, NTRK1 fusion, has also reportedly conferred resistance. Nevertheless, clear‐cut when NSCLCs are driven by EGFR mutation subsequent NTRK fusion lacking. This a case NSCLC wherein exon 19 deletion in (19del) acquired...
Abstract Pseudomyxoma peritonei (PMP) is a rare malignant clinical syndrome with little known about the global mutation profile. In this study, whole-exome sequencing (WES) was performed in 49 appendiceal PMP to investigate profiles and signatures. A total of 4,020 somatic mutations were detected, median number 56 (1–402). Tumor burden (TMB) generally low (median 1.55 mutations/Mb, 0.12–11.26 mutations/Mb). Mutations mainly enriched function cancer-related axonogenesis, extracellular...
<p>Comparison between S1 – S10 signatures in our study and 30 COSMIC database.</p>