A5044302446- Intraperitoneal and Appendiceal Malignancies
- Appendicitis Diagnosis and Management
- Ovarian cancer diagnosis and treatment
- Adrenal and Paraganglionic Tumors
- Inflammatory Biomarkers in Disease Prognosis
- Hernia repair and management
- Hepatocellular Carcinoma Treatment and Prognosis
- Uterine Myomas and Treatments
- Hormonal Regulation and Hypertension
- Diverticular Disease and Complications
- Endometriosis Research and Treatment
- Magnetic Properties and Synthesis of Ferrites
- Anesthesia and Pain Management
- Perfectionism, Procrastination, Anxiety Studies
- GDF15 and Related Biomarkers
- Advancements in Battery Materials
- Omental and Epiploic Conditions
- Abdominal Surgery and Complications
- Neuroendocrine Tumor Research Advances
- Nutrition and Health in Aging
- Radiomics and Machine Learning in Medical Imaging
Aerospace Center Hospital
2020-2025
Peking University
2024-2025
Peking University People's Hospital
2025
University of Messina
2024
Agostino Gemelli University Polyclinic
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2024
Policlinico Abano Terme
2024
Institut National d'Oncologie
2024
Hospices Civils de Lyon
2024
Ospedale Policlinico San Martino
2024
BACKGROUND Pseudomyxoma peritonei (PMP) is a distinct form of peritoneal malignancy characterized by diffuse intra-abdominal gelatinous ascites, with an estimated incidence 1-3 per 1000000. PMP predominantly secondary to appendiceal mucinous neoplasms, rarer origins including the ovaries, colon, and urachus. However, originating from small intestine extremely rare. CASE SUMMARY A 60-year-old male patient presented anorexia abdominal distension. Computed tomography revealed presence...
To investigate the expression of carcinoembryonic antigen (CEA), cancer 125 (CA125), CA19-9, CA724, and CA242 in serum ascites pseudomyxoma peritonei (PMP) patients evaluate predictive value these elevated biomarkers pathological grade, completeness cytoreduction (CC), survival.From May 2009 to October 2019, a total 512 diagnosed with PMP through pathology Aerospace Center Hospital were enrolled. The tumor obtained. diagnostic values between CC compared by receiver operating characteristic...
Abstract Background To explore the application value of hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with incomplete cytoreduction for appendiceal pseudomyxoma peritonei (PMP). Methods We retrospectively analyzed clinical data 526 PMP to discover its prognostic factors, and therapeutic HIPEC. Results The 5-year 10-year overall survival rates after cytoreductive surgery (CRS) treated HIPEC were significantly higher than those without (5y-OS: 58% vs. 48%, 10y-OS: 37% 16%, P =...
To investigate the expression of carcinoembryonic antigen (CEA), cancer 199 (CA199) and CA125 in serum ascites appendiceal pseudomyxoma peritonei (PMP) patients relative to their diagnostic predictive value.The study comprised 183 with pathologically confirmed PMP, enrolled from May 2012 June 2020, Aerospace Center Hospital. Serum tumor markers were obtained, values compared by receiver operating characteristic (ROC) curves. The prognostic factors PMP different pathologic subgroups...
Pseudomyxoma peritonei (PMP) is a rare disorder with unique pathological and genetic changes. Although several studies have reported the clinical features mutational changes of PMP that originates from appendix, few on originating ovary been due to its extreme rarity. In order characterize somatic landscape investigate prognosis predicting factors ovary-originating PMP, we examined 830 cases identified 16 patients originated ovary. Whole-exome sequencing (WES) was performed 12 using...
Abstract Background To investigate the clinical and pathological characteristics of appendiceal mucinous adenocarcinoma with peritoneal metastasis analyze prognostic factors. Methods A retrospective analyses clinicopathological features 50 patients from January, 2013 to December, 2017 in Aerospace Central Hospital, Beijing, China. Survival data calculation comparison were respectively performed Kaplan-Meier method log-rank test. The Cox proportional hazards regression was used for...
This study was conducted in order to investigate the significance of entire appendiceal evaluation pathological diagnosis serrated lesions, low-grade mucinous neoplasm (LAMN), and diverticulosis disease (ADD).A total 702 appendectomy specimens diagnosed from 2017 2020 were reviewed retrospectively. The divided into two groups according different sampling procedures. In group 1, vast majority 337 partially submitted by routine within 18 months October March 2019. 2, 365 entirely examined...
Leiomyomatosis peritonealis disseminata (LPD) is a non-metastatic, homologous, multicentric benign disorder characterized by small leiomyomas scattered over the peritoneum and omentum. It rare disease with invasive potential. LPD mainly attacks women of childbearing age but has also been reported in post-menopausal women, men, young children. Non-specific clinical imaging findings lead to difficult diagnoses treatment.This study reports case patient recurrent endometriosis after multiple...
Peritoneal cancer index (PCI) is the surgical variable most commonly used to quantify extent of peritoneal metastases for pseudomyxoma peritonei (PMP) patients. The present study aimed investigate agreement between CT predicted and PCI by Bland-Altman method PMP appendiceal origin. A total 167 patients origin were included 2016 2021. analysis was performed both selected (regions 2 + 9-12). After plot drawn, mean bias its 95% limit agreements (LoAs) quantified. Besides, correlation...
Abstract Background The peritoneal cancer index (PCI) has been used to predict surgical outcomes for pseudomyxoma peritonei (PMP). present study aimed establish the optimal cutoff point PCI resectability of PMP. Methods A total 366 PMP patients were included. divided into low-grade and high-grade groups. Based on completeness cytoreduction (CC) score, both further complete cytoreductive surgery (CRS) maximal tumor debulking (MTD) subgroups. ability selected (regions 2 + 9 12) was analyzed...
Abstract Background Pseudomyxoma peritonei (PMP) is a rare disease, with the rate of overall survival (OS) influenced by many factors. The present study aimed to define independent predictors and establish nomogram for individual risk prediction in PMP patients. Methods One hundred forty‐seven patients were consecutively included between June 1, 2013, November 22, 2019. log‐rank test was used compare OS groups; subsequently, variables p < .10 subjected multivariate Cox modeling defining...
To describe the clinicopathological characteristics of mucinous ovarian cancer (MOC)-derived pseudomyxoma peritonei (PMP) and identify prognostic factors for survival.Medical records from patients with MOC-derived PMP who attended Aerospace Center Hospital, Beijing, China between January 2009, December 2019 were retrospectively reviewed. Survival analysis was performed Kaplan-Meier method, log-rank test, a Cox proportional hazards model.Cytoreductive surgery (CRS) hyperthermic...
Pseudomyxoma peritonei (PMP) is a clinically malignant tumour syndrome mainly derived from mucin-producing appendiceal tumours. This study aimed to explore the effect of preoperative systemic chemotherapy (PSC) before cytoreductive surgery (CRS) plus hyperthermic intraperitoneal (HIPEC) on safety and postoperative survival in patients with PMP.We performed retrospective analysis including consecutive PMP undergoing primary between January, 2008 December, 2019 Aerospace Center Hospital. The...
Abstract Pseudomyxoma peritonei (PMP) is a rare malignant clinical syndrome with little known about the global mutation profile. In this study, whole-exome sequencing (WES) was performed in 49 appendiceal PMP to investigate profiles and signatures. A total of 4,020 somatic mutations were detected, median number 56 (1–402). Tumor burden (TMB) generally low (median 1.55 mutations/Mb, 0.12–11.26 mutations/Mb). Mutations mainly enriched function cancer-related axonogenesis, extracellular...
To investigate the clinicopathological features and follow-up of low-grade appendiceal mucinous neoplasms (LAMNs) confined to appendix. The features, pathological primary tumor (pT) staging 22 patients with LAMNs appendix were analyzed retrospectively. Of LAMNs, 14 pTis (eight pTism six pTisf), pT3, two pT4a. diameter was significantly larger for pTisf than pTism. interval between first symptoms surgery longer pTism, but not different. No significant differences found pT stages or in...
To investigate the clinical value of laparoscopic cytoreductive surgery (CRS) in treating appendiceal pseudomyxoma peritonei with limited disease and low tumor burden.The data patients treated by CRS at Aerospace Center Hospital from January 2018 to December 2021 were retrospectively analyzed. The divided into or open groups according operation method. A propensity score-matched (PSM) analysis (1:1) was performed, related variables compared between two groups, effect on progression-free...
Objective To determine prognosis for young female patients with peritoneal pseudomyxoma (PMP) of appendiceal origin and unilateral or bilateral ovaries preserved during cytoreductive surgery (CRS). Methods Clinical data treated CRS without hyperthermic intraperitoneal chemotherapy (HIPEC) at the Aerospace Center Hospital, Beijing between January, 2009 December, 2019 were retrospectively reviewed. Patients had no changes in on gross pathological observations biopsy CRS, normal ovarian...
Background Pseudomyxoma peritonei (PMP) is a rare disease, with the overall survival (OS) influenced by many factors. To date, no ascites characteristics have been reported to predict OS of patients PMP. The present study therefore aims describe for PMP and identify prognostic factors survival. Methods Between June 2010 2020, 473 who underwent cytoreductive surgery hyperthermic intraperitoneal chemotherapy were included in retrospective study. Survival analysis was performed Kaplan–Meier...
<p>Comparison between S1 – S10 signatures in our study and 30 COSMIC database.</p>
<p>The residual sum of square curve and percentage explained variance the different number mutational signatures (2 – 30).</p>