A5043973382- Thyroid Disorders and Treatments
- Intraperitoneal and Appendiceal Malignancies
- Adrenal and Paraganglionic Tumors
- Growth Hormone and Insulin-like Growth Factors
- Thyroid Cancer Diagnosis and Treatment
- CAR-T cell therapy research
- Phagocytosis and Immune Regulation
- Hormonal Regulation and Hypertension
- Bone health and treatments
- Ophthalmology and Eye Disorders
- Chronic Lymphocytic Leukemia Research
- Restraint-Related Deaths
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- IgG4-Related and Inflammatory Diseases
- Parathyroid Disorders and Treatments
- Congenital Diaphragmatic Hernia Studies
- Lymphoma Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Digestive system and related health
- Thyroid and Parathyroid Surgery
- Immune Cell Function and Interaction
- Ion Transport and Channel Regulation
- Head and Neck Anomalies
- Amyloidosis: Diagnosis, Treatment, Outcomes
Yangzhou University
2025
Keio University
2024-2025
Xuzhou Medical College
2025
Second People’s Hospital of Huai’an
2025
Tongliao Academy of Agricultural Sciences
2025
Xinjiang Medical University
2024
Sino Biopharmaceutical (China)
2024
Capital Medical University
2023
Beijing Shijitan Hospital
2023
Universitätsmedizin Greifswald
1986-2004
Objective: To test the hypothesis that untreated overt and subclinical thyroid disorders autoimmune thyroiditis (AIT) are associated with mental physical complaints in general population. Method: A total of 3790 participants from Study Health Pomerania (SHIP) no known were analyzed concerning their function (TSH, FT3, FT4), autoantibodies (TPO‐Ab), structure size (Zerssen Complaint Scale). Results: Overt hyperthyroidism (prevalence: 0.4%) was a significantly lower complaint‐score than...
Objective: Little information exists from formerly iodine-deficient areas regarding gender-specific risk factors for goiter and their synergisms. The aim of the present study was to investigate such interactions in a large population-based sample. Methods Results: Study Health Pomerania (SHIP) comprised 4310 randomly selected participants, aged 20 - 79 years. SHIP performed previously region. Data 3915 participants with no known thyroid disorders were analyzed. Goiter determined by...
ABSTRACT Background Immune system modulation has been shown to have a significant impact on attention deficit hyperactivity disorder (ADHD). Mendelian randomization (MR) analysis was used in this study investigate the potential role of different immune cells development ADHD provide therapy and preventative alternatives. Methods In study, 731 risk were examined using publicly accessible genetic data two‐sample MR analysis. Included four types immunological profiles: determinate (DC),...
Trefoil factor 3 (TFF3) and epidermal growth (EGF) exert a promotive effect on the functions of intestinal epithelial cells offer protection to mucosa. Lactobacillus paracasei can ameliorate mucosal damage. In this study, pPG-pTFF3/27-2, pPG-pEGF/27-2, pPG-pTE/27-2 were constructed express porcine TFF3, EGF, fusion protein (pTE). Functional assays showed they promoted Immortalized Porcine Enterocyte Cell line J2 (IPEC-J2) proliferation migration, with pTE having greater migratory effect....
Thiacloprid (THI) is a synthetic insecticide, the misuse targeted chiefly to control aphid pest species in orchards and vegetables. Melatonin (MET) hormone that plays crucial physiological roles anti-inflammatory capacities of fish. We explored function MET (100 μM) mitigate toxicity induced by THI (20 lymphocytes. Our results indicate led notable rise lymphocyte mortality. Lymphocytes exposed exhibited heightened incidence pyroptosis, accompanied upregulation expression associated with...
Methane is an important component of greenhouse gases, and ruminant production a significant source methane emissions. At present, flavonoid feed additives have certain applications in inhibition ruminants. However, the effects different doses quercetin on rumen fermentation parameters, bacteria archaea are still unclear. Therefore, this study investigated vitro production, microflora beef cattle. A completely randomized design was adopted. Quercetin added to substrates at 0% (group C), 0.5%...
7527 Background: IMM0306 is a fusion protein of CD20 monoclonal antibody with the CD47 binding domain SIRPα on both heavy chains. It has higher affinity for than CD47, thus enabling its preferential and simultaneous to malignant B cells rather CD47-postive normal tissues. Here, we report safety, pharmacokinetics (PK), pharmacodynamics (PD), efficacy results dose escalation stage in phase I/II study patients (pts) relapsed or refractory CD20-positive B-cell non-Hodgkin's lymphoma. Methods:...
7060 Background: IMM0306 is a fusion protein of CD20 monoclonal antibody with the CD47 binding domain SIRPα on both heavy chains. It exerts excellent cancer killing efficacy by activating macrophages and NK cells via blockade CD47-SIRPα interaction FcɣR engagement. Here, we report safety, pharmacokinetics (PK), pharmacodynamics (PD), results phase I study in patients (pts) relapsed or refractory (R/R) CD20-positive B-cell non-Hodgkin's lymphoma (B-NHL). Methods: Eligible pts R/R B-NHL were...
The aim of the paper was to study effectiveness individualized comprehensive nutritional support on inflammatory markers, serum amylase (AMS), prealbumin (PA), albumin (ALB), calcium ion (Ca2+) in patients with severe acute pancreatitis (SAP). 102 participants SAP treated our hospital were chosen as objects. randomly split into a control group and an observation both groups given routine treatment. Additionally, received nutrition support. indexes, biochemical indexes symptom improvement...
7017 Background: Timdarpacept (IMM01), a recombinant SIRPa-Fc fusion protein, can activate macrophages to enhance anti-tumor activity by blocking CD47-SIRPa interaction. IMM01 showed unique property of weak human erythrocyte conjugation in preclinical studies, and low incidence anemia early clinical trials with no need for priming dose. combination tislelizumab has the potential augment both innate adaptive immune responses. Methods: Eligible patients R/R classical Hodgkin lymphoma (cHL) who...
To investigate the characteristics of adolescents' school adjustment and their associations with anxiety, depression, stress, respectively, as well differences by gender. A convenience sampling method was used to measure 3,922 secondary students from 10 schools in five locations Xinjiang Uygur Autonomous Region using Anxiety-Depression-Stress Scale School Adjustment Scale, latent profile analysis identify subjects' categories, network subsequently explore relationship between different...
Abstract Pseudomyxoma peritonei (PMP) is a rare malignant clinical syndrome with little known about the global mutation profile. In this study, whole-exome sequencing (WES) was performed in 49 appendiceal PMP to investigate profiles and signatures. A total of 4,020 somatic mutations were detected, median number 56 (1–402). Tumor burden (TMB) generally low (median 1.55 mutations/Mb, 0.12–11.26 mutations/Mb). Mutations mainly enriched function cancer-related axonogenesis, extracellular...
Hereditary medullary thyroid carcinoma (MTC) is caused by germline mutations of the RET proto-oncogene. A genotype - phenotype correlation has been established, showing clustering in exons 10 and 11 classical MEN 2 syndrome, exon 16 codon 918 B syndrome 13-15 familial MTC. line evidence suggested that development aggressiveness MTC different cancer syndromes variable. Aim this study was to compare with mutation possibly draw therapeutical consequences.We compared 47 patients 66 11, 634...
Ziel: Untersuchung des funktionsdiagnostischen Wertes Doppler-sonographischer beziehungsweise sonographischer Parameter insbesondere der Spitzenflußgeschwindigkeit in Arteria thyreoidea inferior bei Patienten mit einer neu auftretenden Autoimmunthyreoiditis. Material und Methode: Dazu wurden 69 aufgetretenem Morbus Basedow Thyreoiditis Hashimoto sowie Kontrollgruppe von 18 Personen morphologische Doppler-sonographische Messungen an durchgeführt. Die Meßergebnisse den...
Co-morbid anxiety and depression (CAD) is defined as the co-existence of depression. During pregnancy, women are more prone to negative emotions, such depression, than general female population. The incidence CAD during pregnancy 1-26 %. aims this study were investigate influencing factors pregnancy. cohort included 3053 pregnant who underwent maternity check-ups at a tertiary hospital in China. Demographic characteristics, level social support, psychological characteristics collected from...
<p>Comparison between S1 – S10 signatures in our study and 30 COSMIC database.</p>
<p>The residual sum of square curve and percentage explained variance the different number mutational signatures (2 – 30).</p>
<p>Hypothesis model of mutation-cluster-based molecular pathogenesis and prognosis PMP.</p>
<div>Abstract<p>Pseudomyxoma peritonei (PMP) is a rare malignant clinical syndrome with little known about the global mutation profile. In this study, whole-exome sequencing (WES) was performed in 49 appendiceal PMP to investigate profiles and signatures. A total of 4,020 somatic mutations were detected, median number 56 (1–402). Tumor burden (TMB) generally low (median 1.55 mutations/Mb, 0.12–11.26 mutations/Mb). Mutations mainly enriched function cancer-related axonogenesis,...