A5018558028- Stroke Rehabilitation and Recovery
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Acute Ischemic Stroke Management
- Neurogenesis and neuroplasticity mechanisms
- Cerebral Palsy and Movement Disorders
- Epilepsy research and treatment
- Ion channel regulation and function
- Growth Hormone and Insulin-like Growth Factors
- Neurological Disease Mechanisms and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiovascular and exercise physiology
- Genomics, phytochemicals, and oxidative stress
- Cardiac Health and Mental Health
- Social and Educational Sciences
- Receptor Mechanisms and Signaling
- Children's Physical and Motor Development
- Physical Activity and Health
- Musculoskeletal pain and rehabilitation
- Alzheimer's disease research and treatments
- RNA regulation and disease
- Healthcare professionals’ stress and burnout
- Botulinum Toxin and Related Neurological Disorders
- Sulfur Compounds in Biology
- Traumatic Brain Injury Research
Nanyang Technological University
2019-2025
University of Newcastle Australia
2016-2025
Hunter Medical Research Institute
2016-2025
John Hunter Hospital
2014-2025
Hunter New England Local Health District
2025
University of Gothenburg
2014-2023
National Health and Medical Research Council
2016-2022
La Trobe University
2019-2021
Florey Institute of Neuroscience and Mental Health
2017-2021
The University of Melbourne
2021
The fetal and even the young brain possesses a considerable degree of plasticity. plasticity rate neurogenesis in adult is much less pronounced. present study was conducted to investigate whether housing conditions affect neurogenesis, learning, memory rats. Three-month-old rats housed either isolation or an enriched environment were injected intraperitoneally with bromodeoxyuridine (BrdU) detect proliferation among progenitor cells follow their fate dentate gyrus. sacrificed 1 day 4 weeks...
Reactive astrocytes are thought to protect the penumbra during brain ischemia, but direct evidence has been lacking due absence of suitable experimental models. Previously, we generated mice deficient in two intermediate filament (IF) proteins, glial fibrillary acidic protein (GFAP) and vimentin, whose upregulation is hallmark reactive astrocytes. GFAP −/− Vim exhibit attenuated posttraumatic gliosis, improved integration neural grafts, regeneration. Seven days after middle cerebral artery...
During early adulthood, a phase in which the central nervous system displays considerable plasticity and important cognitive traits are shaped, effects of exercise on cognition remain poorly understood. We performed cohort study all Swedish men born 1950 through 1976 who were enlisted for military service at age 18 (N = 1,221,727). Of these, 268,496 full-sibling pairs, 3,147 twin 1,432 monozygotic pairs. Physical fitness intelligence performance data collected during conscription...
Upon cerebral hypoxia-ischemia (HI), apoptosis-inducing factor (AIF) can move from mitochondria to nuclei, participate in chromatinolysis, and contribute the execution of cell death. Previous work (Cande, C., N. Vahsen, I. Kouranti, E. Schmitt, Daugas, C. Spahr, J. Luban, R.T. Kroemer, F. Giordanetto, Garrido, et al. 2004. Oncogene. 23:1514–1521) performed vitro suggests that AIF must interact with cyclophilin A (CypA) form a proapoptotic DNA degradation complex. We addressed question as...
Purpose: An enriched environment (EE) facilitates physical, cognitive and social activity in animal models of stroke. The aim this pilot study was to determine whether enriching the a mixed rehabilitation unit increased stroke patient activity. Methods: A non- randomized controlled trial conducted. Direct observation used difference change cognitive, or any over 2 weeks patients exposed an versus non-enriched environment. Results: Stroke EE (n = 15) were 1.2 (95% CI 1.0–1.4) times more...
Choir singing is known to promote wellbeing. One reason for this may be that demands a slower than normal respiration which in turn affect heart activity. Coupling of rate variability (HRV) called Respiratory sinus arrhythmia (RSA). This coupling has subjective as well biologically soothing effect, and it beneficial cardiovascular function. RSA seen more marked during slow-paced breathing at lower rates (0.1 Hz below). In study, we investigate how singing, form guided breathing, affects HRV...
Studies suggest a role for cardiovascular fitness in the prevention of affective disorders.To determine whether at age 18 is associated with future risk serious illness.Population-based Swedish cohort study male conscripts (n = 1 117 292) born 1950-1987 no history mental illness who were followed 3-40 years. Data on conscription linked national hospital registers to calculate depression (requiring in-patient care) and bipolar disorder.In fully adjusted models low was increased (hazard ratios...
Patients with early-onset dementia are a significantly under-recognized subgroup of patients an increasing prevalence. Epidemiological studies limited and modifiable risk factors, such as physical fitness, lacking. We aimed to investigate the associations between cardiovascular fitness individually in combination cognitive performance at age 18 mild impairment later life. performed population-based cohort study over 1.1 million Swedish, 18-year-old, male conscripts, who underwent...
Background and Purpose— Treatments that improve function in late phase after stroke are urgently needed. We assessed whether multimodal interventions based on rhythm-and-music therapy or horse-riding could lead to increased perceived recovery functional improvement a mixed population of individuals stroke. Methods— Participants were assigned therapy, control using concealed randomization, stratified with respect sex laterality. Therapy was given twice week for 12 weeks. The primary outcome...
Stroke recovery research involves distinct biological and clinical targets compared to the study of acute stroke. Guidelines are proposed for pre-clinical modeling stroke alignment studies trials in recovery.
Oxidative stress is heavily implicated in the pathogenic process of Parkinson's disease. Varying capacity to detoxify radical oxygen species through induction phase II antioxidant enzymes substantia nigra may influence disease risk. Here, we hypothesize that variation NFE2L2 and KEAP1, genes encoding two major regulators response, affect risk The study included a Swedish discovery case-control material (165 cases 190 controls) Polish replication (192 192 controls). Eight tag single...