A5075481727- Transcranial Magnetic Stimulation Studies
- Neuroscience and Neuropharmacology Research
- Stroke Rehabilitation and Recovery
- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Neurogenesis and neuroplasticity mechanisms
- Acute Ischemic Stroke Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Optical Imaging and Spectroscopy Techniques
- Traumatic Brain Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Photoacoustic and Ultrasonic Imaging
- Neuroscience and Neural Engineering
- Muscle activation and electromyography studies
- EEG and Brain-Computer Interfaces
- Motor Control and Adaptation
- Neurological Disease Mechanisms and Treatments
- Pain Mechanisms and Treatments
- Thermoregulation and physiological responses
- Zebrafish Biomedical Research Applications
- Neurotransmitter Receptor Influence on Behavior
- Botulinum Toxin and Related Neurological Disorders
- Advanced Fluorescence Microscopy Techniques
- Plant and animal studies
- Mitochondrial Function and Pathology
The University of Texas at Austin
2015-2024
Institute of Psychology
2020
Jones Institute
2019
Park Nicollet Methodist Hospital
2014
Illinois Wesleyan University
2013
Medical University of South Carolina
2013
Google (United States)
2008
University of Washington
1998-2002
Howard Hughes Medical Institute
1999
Stanford University
1999
This paper reviews 10 principles of experience-dependent neural plasticity and considerations in applying them to the damaged brain.Neuroscience research using a variety models learning, neurological disease, trauma are reviewed from perspective basic neuroscientists but manner intended be useful for development more effective clinical rehabilitation interventions.Neural is believed basis both learning intact brain relearning that occurs through physical rehabilitation. Neuroscience has made...
Unilateral damage to the forelimb representation area of sensorimotor cortex in adult rats increases dendritic arborization layer V pyramidal neurons contralateral homotopic cortex. Arbor size was maximum at approximately 18 d postlesion, following which there a partial elimination, or pruning, processes. These neural changes were closely associated with behavioral events. The overgrowth dendrites related time disuse (to lesion) and over-reliance on ipsilateral for postural exploratory...
Synaptic vesicle protein 2 (SV2) is a membrane glycoprotein common to all synaptic and endocrine vesicles. Unlike many proteins involved in exocytosis, SV2 has no homolog yeast, indicating that it performs function unique secretion higher eukaryotes. Although the structure interactions of suggest multiple possible functions, its role events remains unknown. To explore an vivo context, we generated mice do not express primary isoform, SV2A, by using targeted gene disruption. Animals...
The organization of forelimb representation areas the monkey, cat, and rat motor cortices has been studied in depth, but its characterization mouse lags far behind. We used intracortical microstimulation (ICMS) cytoarchitectonics to characterize general C57BL/6 cortex, more detail. found that region spans a large area frontal bordered primarily by vibrissa, neck, shoulder, hindlimb representations. It included caudal area, dominated digit representation, small rostral containing elbow wrist...
Brain injury causes astrocytes to assume a reactive state that is essential for early tissue protection, but how affect later reparative processes incompletely understood. In this study, we show are crucial vascular repair and remodeling after ischemic stroke in mice. Analysis of astrocytic gene expression data reveals substantial activation transcriptional programs related stroke. vivo two-photon imaging provides evidence contacting newly formed vessels cortex surrounding photothrombotic...
To assess behavioral experience effects on synaptic plasticity after brain damage, the present study examined of complex motor skills training (the acrobatic task) changes in layer V cortex opposite unilateral damage to forelimb sensorimotor (FLsmc). Adult male rats were given lesions or sham operations followed by 28 d task [acrobat condition (AC)]. As a activity control [motor (MC)], lesion and animals simple repetitive exercise. Previously, FLsmc have independently been found result...
This study assessed the behavioral and dendritic structural effects of combining subdural motor cortical electrical stimulation with skills training following unilateral sensorimotor cortex lesions in adult male rats. Rats were pre-operatively trained on a skilled forelimb reaching task, Montoya staircase test, then received endothelin-1 induced ischemic cortex. Ten to 14 days later, electrodes implanted over peri-lesion surface. subsequently began 10 rehabilitative task 1 3 conditions: 1....
Stroke recovery research involves distinct biological and clinical targets compared to the study of acute stroke. Guidelines are proposed for pre-clinical modeling stroke alignment studies trials in recovery.
In humans and other animals, sufficient unilateral damage to the sensorimotor cortex can cause impairments in opposite forelimb development of a hyper-reliance on nonimpaired limb. This is adaptive extent that it contributes functional compensation for lesion-induced impairments. We have found lesions region (FLsmc) rats, or callosal transections, neurons motor become exceptionally responsive changes behavior. enhanced responsiveness might facilitate learning compensatory strategies with...
Exercise and rehabilitative training each have been implicated in the promotion of restorative neural plasticity after cerebral injury. Because motor skill induces synaptic exercise increases plasticity-related proteins, we asked if could improve efficacy on a skilled task focal cortical lesions.Female young middle-aged rats were trained single-pellet retrieval received unilateral ischemic sensorimotor cortex lesions contralateral to limb. Rats then both, either, or neither voluntary running...
is as necessary anatomical or chemical data in evaluating the success of