A5101936319- Immunotherapy and Immune Responses
- Nanoparticles: synthesis and applications
- Monoclonal and Polyclonal Antibodies Research
- Effects and risks of endocrine disrupting chemicals
- RNA Interference and Gene Delivery
- Pluripotent Stem Cells Research
- Glycosylation and Glycoproteins Research
- Air Quality and Health Impacts
- Virus-based gene therapy research
- Reproductive System and Pregnancy
- Heavy Metal Exposure and Toxicity
- 3D Printing in Biomedical Research
- Zebrafish Biomedical Research Applications
- Toxin Mechanisms and Immunotoxins
- Biomedical Ethics and Regulation
- Atherosclerosis and Cardiovascular Diseases
- Biosensors and Analytical Detection
- Biomarkers in Disease Mechanisms
- Mesenchymal stem cell research
- Extracellular vesicles in disease
- Industrial Gas Emission Control
- Telomeres, Telomerase, and Senescence
- Pregnancy-related medical research
- Autophagy in Disease and Therapy
- Nuclear Receptors and Signaling
Research Center for Eco-Environmental Sciences
2015-2022
Chinese Academy of Sciences
2015-2022
University of Chinese Academy of Sciences
2016-2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2016
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2013
Osaka University
2009-2012
Zhejiang University
2010-2011
Osaka University of Pharmaceutical Sciences
2009
ADVERTISEMENT RETURN TO ISSUEPREVViewpointNEXTThe Rise of Stem Cell ToxicologyFrancesco Faiola*, Nuoya Yin, Xinglei Yao, and Guibin JiangView Author Information State Key Laboratory Chemistry Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy Beijing 100085, China*E-mail: [email protected]Cite this: Environ. Sci. Technol. 2015, 49, 10, 5847–5848Publication Date (Web):May 5, 2015Publication History Received27 March 2015Published online5 May inissue 19...
Silver nanoparticles (AgNPs) are one of the most commonly used nanomaterials; however, it remains unclear whether AgNPs induce neurotoxicity. Here, we investigated potential neurological effects and neuroprotective effect vitamin E (VE). We found that intranasal instillation in neonatal Sprague-Dawley rats caused significant body weight loss. Moreover, histological examinations revealed activation neuroglial cells with concomitant destruction granular layer cerebellum. Furthermore, western...
Neural stem cells (NSCs) are ideal candidates in cell-based therapy for neurodegenerative diseases. However, it is unfeasible to get enough quantity of NSCs clinical application. Generation from human adipose-derived mesenchymal (hAD-MSCs) will provide a solution this problem. Currently, the differentiation hAD-MSCs into highly purified with biological functions rarely reported. In our study, we established three-step NSC-inducing protocol, which were induced generate high purity after...
Tetrabromobisphenol A (TBBPA), a ubiquitous environmental pollutant, has been implicated in developmental toxicity of aquatic animals. However, the impact TBBPA on development and related mechanism have not fully elucidated. In this study, using live imaging technique transgenic labeling zebrafish embryos, we described toxic effects hematopoietic zebrafish. We demonstrated that induced erythroid precursor expansion intermediate cell mass (ICM), which perturbed onset blood circulation at...
Abstract Environmental pollution is a global problem; the lack of comprehensive toxicological assessments may lead to increased health risks. To fully understand effects pollution, it paramount implement fast, efficient and specific toxicity screening that relies on human models rather than time-consuming, expensive often inaccurate tests involving live animals. Human stem cell toxicology represents valid alternative traditional assays because takes advantage ability cells differentiate into...
Recently, it has been suggested that cellular senescence is associated with stem cell exhaustion, which reduces the regenerative potential of tissues and contributes to aging age-related diseases. Mesenchymal cells (MSCs) attract a large amount attention in research regeneration medicine because they possess multiple advantages senescent MSCs could be one most useful models studies. It important quantitatively evaluate markers both identify study mechanisms involved MSC senescence. Reverse...
Bisphenol S (BPS) is a bisphenol A (BPA) replacement that widely present in the environment and humans. The association between obesity BPS has been reported epidemiological studies; however, obesogenic effect related mechanism of remain poorly understood. In this study, high-resolution microcomputed tomography analysis showed volume visceral fat was significantly increased BPS-treated mice. Moreover, higher potency to induce formation mice than BPA at exposure concentration 5 mg/kg/day for...
As the prevalence of obesity increases, so does occurrence obesity-related complications, such as cardiovascular and cerebrovascular diseases, diabetes, some cancers. Increased adipose tissue is main cause harm in obesity. To better understand its related we analyzed mRNA expression profiles tissues from 126 patients with 275 non-obese controls. Using an integrated bioinformatics method, explored functions 113 differentially expressed genes (DEGs) between them. Gene ontology (GO) kyoto...
Nanomaterials are widely used in a variety of industrial, biological, and medical applications. Therefore, high concerns about their possible impact on human environmental health have been raised. Here, we describe high-throughput single-cell imaging method to reveal the crosstalk among quantum dot (QDot)-induced ROS generation, apoptosis, changes nucleus size macrophages. In triple marker combinations, assessed correlations three QDot-induced cellular responses via divided subsets based...