A5100616635- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Lymphoma Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Helicobacter pylori-related gastroenterology studies
- Multiple Myeloma Research and Treatments
- Histone Deacetylase Inhibitors Research
- Ubiquitin and proteasome pathways
- Protein Degradation and Inhibitors
- Esophageal and GI Pathology
- Acute Myeloid Leukemia Research
- Peptidase Inhibition and Analysis
- Neutropenia and Cancer Infections
- Sleep and related disorders
- Cancer Immunotherapy and Biomarkers
- Infant Development and Preterm Care
- Eosinophilic Esophagitis
- Gastroesophageal reflux and treatments
- Colorectal Cancer Screening and Detection
- Congenital Heart Disease Studies
- Endoplasmic Reticulum Stress and Disease
- Gastrointestinal motility and disorders
- Mycobacterium research and diagnosis
- Retinoids in leukemia and cellular processes
- Cancer Mechanisms and Therapy
Shanghai Ninth People's Hospital
2014-2025
Shanghai Jiao Tong University
2016-2025
Guangzhou Center for Disease Control and Prevention
2025
Fudan University
2025
Soochow University
2023-2024
First Affiliated Hospital of Jiangxi Medical College
2024
Shanghai First People's Hospital
2008-2024
Shanghai Children's Medical Center
2023-2024
Chinese People's Liberation Army
2024
XinHua Hospital
2023
Locally advanced oral squamous cell carcinoma (LAOSCC) is associated with a high rate of recurrence and poor survival. Given the recent successes neoadjuvant immunochemotherapy (NAICT) in solid tumors, it promising to use this treatment modality achieve better pathological response improve survival LAOSCC, clinical evidence needed assess its safety efficacy.A prospective trial NAICT toripalimab (PD-1 inhibitor) albumin paclitaxel/cisplatin (TTP) was conducted patients stage III IVA OSCC....
Lysine methyltransferase KMT5C catalyzes deposition of trimethylation on histone H4 lysine 20 (H4K20me3), an epigenetic marker usually associated with gene repression and maintenance heterochromatin. is widely expressed in a variety tissues, however, its functional role liver has not been explored. Here, we show Kmt5c fasting- glucagon-induced which regulates hepatic gluconeogenesis. Loss hepatocytes results downregulated gluconeogenic expression compromised glucose output during fasting....
Excessive screen time has been associated with a higher risk for mental health problems, but whether the associations differ by content types is unclear.
Abstract Background The preparation of the middle mesial (MM) canal mandibular molars represents a challenge because it is often curved, narrow, and close to root concave. purpose this study was evaluate ex vivo shaping ability 3 nickel-titanium (NiTi) rotary systems in MM using 3D printed resin tooth replicas. Methods A permanent first molar with acquired from pool extracted teeth reproduced by printer. replicas ( n = 18) were equally assigned groups for evaluation abilities NiTi (OneShape...
Chemo-resistance is still a major obstacle in efforts to overcome acute myeloid leukemia (AML). An emerging concept has proposed that interactions between the bone marrow (BM) microenvironment and cells reduce sensitivity of chemotherapy. As an important element tumor microenvironment, cancer-associated fibroblasts (CAFs) are considered be activated modulators chemo-resistance many solid tumors. But their contribution AML yet fully understood. Here we report critical role for CAFs which were...
Importance Sleep disturbances and mental health problems are highly comorbid bidirectionally correlated across childhood. The association between the natural history of sleep transition has not been quantified. Objective To examine resolved incident emotional behavioral difficulties (EBDs). Design, Setting, Participants This cohort study used data from Shanghai Children’s Health, Education Lifestyle Evaluation–Preschool (SCHEDULE-P), a prospective population-based longitudinal children...
Hypoxia inducible factor-1α (HIF-1α) is associated with human breast cancer chemoresistance. Various reports have suggested that multiple pathways are involved in HIF-1α induction and the molecular mechanisms regulating HIF-1α-induced chemoresistance still not fully understood. Here, we report anterior gradient 2 (AGR2), a proposed biomarker, an essential regulator hypoxia-induced doxorubicin resistance through binding stabilization of HIF-1α. Our results show knockdown AGR2 MCF-7 cells...
Anterior gradient 2 (AGR2), a member of protein disulfide isomerase (PDI) family, is both located in cytoplasm and secreted into extracellular matrix. The orthologs AGR2 have been linked to limb regeneration newt wound healing zebrafish. In mammals, influences multiple cell signaling pathways tumor formation normal functions related new tissue like angiogenesis. However, the function mammalian remains unknown. This study aimed investigate expression its during skin possible application...
Common genetic variations in genes involved DNA repair or response to genotoxic stress may influence both cancer susceptibility and treatment individually interactively. However, acute myeloid leukemia (AML), the relevance of these remains be fully established. In this study, we analyzed 42 among 15 candidate 307 AML patients 560 age-sex matched controls. Their associations with chemotherapy were further evaluated combination other well-established prognostic factors. An increased risk was...
The development of a more effective and less toxic salvage regimen remains major challenge in elderly patients with relapsed and/or refractory peripheral T-cell lymphoma (PTCL). From April 2004 to May 2010, we used new combining gemcitabine, oxaliplatin dexamethasone (GemOD) 24 (n = 11) or 13) PTCL unsuitable for high dose therapy. GemOD consisted gemcitabine (1000 mg/m2 on day 1), (100 1) (20 mg/day from 1 4), which was given every 3 weeks. Patients were scheduled receive up six courses...
Abstract Background Diffuse large B‐cell lymphoma (DLBCL) patients refractory to rituximab‐based immunochemotherapy have a dismal prognosis. However, the definition of DLBCL remains inconsistent and no cohort study data is available from Asian countries. To validate outcomes in China, we conducted multicenter, retrospective study. Methods The REtrospective AnaLysis Treatment REspoNse (REAL‐TREND) was performed using real‐world 8 centers China. with curative intent were included REAL‐TREND...
Abstract Mother–child interaction is highly dynamic and reciprocal. Switching roles in these back‐and‐forth interactions serves as a crucial feature of reciprocal behaviors while the underlying neural entrainment still not well‐studied. Here, we designed role‐controlled cooperative task with dual EEG recording to explore how differently two brains interact when mothers children hold different roles. When were actors observers, mother–child interbrain synchrony emerged primarily within theta...
Mass vaccination represents a highly effective strategy for accelerating disease control while simultaneously reducing incidence and mortality rates. By developing comprehensive plans standards mass vaccination, it is feasible to optimize resource allocation swiftly enhance coverage, thereby preventing, controlling, or interrupting outbreaks epidemics of specific infectious diseases. To standardize the process establish population immunity barrier in an orderly, efficient, safe manner, panel...
Accurate staging of gastric cancer is helpful to determine the most appropriate therapy, but no modality has been accepted as standard. Objective evaluate usefulness endoscopic ultrasonograph (EUS) combined with position emission tomography and computed tomograph (PET-CT) in staging. A total 124 patients confirmed were subjected EUS PET-CT scanning. The detection rate primary tumor was 99.2% by combination use two modalities 97.6% alone (p = 0.6219), 90.3% (112 124) (compared combination, p...
Anterior gradient 2 (AGR2) is a promising anti-tumor target associated with estrogen receptor expression and metastatic progression of breast cancer. Insulin-like growth factor-1 (IGF-1) another potent factor that stimulates cancer mediates anti-estrogen drug resistance. However, the precise mechanism connections between these two factors in resistance have not been fully elucidated. Here, for first time, we decipher IGF-1 remarkably induces AGR2 MCF7 cell line, through an response element...