A5066059291- Genetics, Aging, and Longevity in Model Organisms
- Endoplasmic Reticulum Stress and Disease
- Cancer Mechanisms and Therapy
- Hemophilia Treatment and Research
- Renal and related cancers
- Platelet Disorders and Treatments
- Wound Healing and Treatments
- Immunotherapy and Immune Responses
- Nigella sativa pharmacological applications
- Trace Elements in Health
- Hemostasis and retained surgical items
- Estrogen and related hormone effects
- Phagocytosis and Immune Regulation
- Mitochondrial Function and Pathology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- RNA and protein synthesis mechanisms
- Kruppel-like factors research
- GABA and Rice Research
- Multiple Myeloma Research and Treatments
- Chronic Myeloid Leukemia Treatments
- Circadian rhythm and melatonin
- Aldose Reductase and Taurine
- RNA modifications and cancer
- Burn Injury Management and Outcomes
- Fish Biology and Ecology Studies
Shanghai Jiao Tong University
2015-2022
Central Institute of Medicinal and Aromatic Plants
2016-2017
Gurukul Kangri Vishwavidyalaya
2011
Anterior gradient 2 (AGR2), a member of protein disulfide isomerase (PDI) family, is both located in cytoplasm and secreted into extracellular matrix. The orthologs AGR2 have been linked to limb regeneration newt wound healing zebrafish. In mammals, influences multiple cell signaling pathways tumor formation normal functions related new tissue like angiogenesis. However, the function mammalian remains unknown. This study aimed investigate expression its during skin possible application...
b-ZIP transcription factor ZIP-10 has emerged as a key regulator of innate immunity in Caenorhabditis elegans(C. elegans). regulatory protein multifarious role development, stress response, metabolism, and immune modulation triggered by pathogenic infection. Since most the signaling pathways are conserved across species, future studies envisioned to provide new tools hypothesis generation/testing aimed at deciphering fundamental defense mechanisms relevant infectious disease(s). This review...
Anterior gradient 2 (AGR2) is a promising anti-tumor target associated with estrogen receptor expression and metastatic progression of breast cancer. Insulin-like growth factor-1 (IGF-1) another potent factor that stimulates cancer mediates anti-estrogen drug resistance. However, the precise mechanism connections between these two factors in resistance have not been fully elucidated. Here, for first time, we decipher IGF-1 remarkably induces AGR2 MCF7 cell line, through an response element...
Sal-like protein 2 (Sall2), a homeotic transcription factor, is putative tumor suppressor. We have previously shown that Sall2 activates the of suppressor gene p21 and suppresses tumorigenesis through cell cycle inhibition induction apoptosis. To investigate additional Sall2-regulated downstream genes, we analyzed differences in mRNA expression profiles with without exogenously expressed Sall2. identified 1616 Sall2-responsive genes arrays. Promoter-reporter assays p16(INK4A) several other...
Species from lower invertebrates to a spectrum of mammals show antiaging health benefits phytochemical(s). Here, we explored the pro-longevity effects natural triterpenoid, ursolic acid (3β-hydroxy-urs-12-en-28-oic acid; UA) in Caenorhabditis elegans with maximal life span being evident at 25 µM UA. Similar eat-2 mutants, UA uptake by worm results reduced fat storage and attenuation reactive oxygen species (ROS), independent superoxide dismutase(s) activation. The genetic requirements for...
Alnus nitida is used for multiple disorders in norther areas of Pakistan. In this study we have evaluated methanol extract leaf (ANL) and stem bark (ANB) A. against two lung cancer cell lines; A-549 H460 (Human non-small lines) during vitro assays growth inhibition. Treatment with ANL ANB markedly inhibited the both lines. Exposure lines to survival, colony migration cells. Further, treatment indicated alteration actin fibers after staining rhodamine-phalloidin. Both extracts cause shrinkage...
Several aminoacyl-tRNA synthetases have been reported to be overexpressed for charging essential aminoacyl-tRNAs in many cancer types. In this study, we aimed explore the potential role of leucyl-tRNA synthetase (LARS) as an anticancer target. MTT assay was performed screen inhibitors human LARS (hsLARS) from compounds AN2690 and its derivatives, 1-6, U2OS SKOV3 cells. The compound with strongest inhibitory ability further investigated effect cell lines animal tumor model. Additionally, a...
The most prominent cancer-associated fibroblasts (CAFs) in tumor stroma is known to form a protective structure support growth. Anterior gradient-2 (AGR2), secretory protein believed play pivotal role during microenvironment (TME) development. Here, we report that extracellular AGR2 enhances elongation and migration significantly. early stimulation of RhoA showed the association by upregulation G1-S phase-regulatory cyclin D1 FAK phosphorylation through growth factor receptor (FGFR) vascular...
Tor putitora (mean wt., 86.69±1.26 g, mean total length, 19.73±0.40 cm) were exposed for 30 days to varying concentrations (3, 6, 12, and 24 ml/L) of paper mill effluent with a view check the haematological changes. Red blood cell count (RBCC), haemoglobin (Hb), packed volume (PCV), corpuscular (MCV), (MCH), content (MCHC), white (WBCC), neutrophils, monocytes small lymphocytes 2.17±0.01†1.90±0.01×106/mm3, 8.8±0.02â€Â6.5±0.02 g%, 27.34±0.24â€Â27.02±0.28%,...