A5047520528- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Essential Oils and Antimicrobial Activity
- Drug Solubulity and Delivery Systems
- Bee Products Chemical Analysis
- Nanoparticle-Based Drug Delivery
- Nanocomposite Films for Food Packaging
- Hydrogels: synthesis, properties, applications
- Phytochemicals and Antioxidant Activities
- Diabetes Treatment and Management
- Analytical Methods in Pharmaceuticals
- Curcumin's Biomedical Applications
- Ocular Surface and Contact Lens
- Dermatology and Skin Diseases
- Potassium and Related Disorders
- Inhalation and Respiratory Drug Delivery
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Chalcogenide Semiconductor Thin Films
- Nanoparticles: synthesis and applications
- Nanoplatforms for cancer theranostics
- Bone Tissue Engineering Materials
- Chemotherapy-related skin toxicity
- Lipid Membrane Structure and Behavior
- Hip and Femur Fractures
Nanjing University of Aeronautics and Astronautics
2025
Gomal University
2011-2024
King's College Hospital
2024
University of Science and Technology Bannu
2019-2024
Hayatabad Medical Complex
2023
Khyber Teaching Hospital
2023
Patna Medical College and Hospital
2023
Pir Mehr Ali Shah Arid Agriculture University
2022
Higher Colleges of Technology
2022
University of Wah
2022
Nanoparticles play a vital role in cancer treatment to deliver or direct the drug malignant cell, avoiding attacking of normal cells. The aim study is formulate folic-acid-modified chitosan nanoparticles for colon cancer. Chitosan was successfully conjugated with folic acid produce acid-chitosan conjugate. folate-modified loaded 5-FU using ionic gelation method. prepared were characterized size, zeta potential, surface morphology, contents, entrapment efficiency, loading and vitro release...
(1) Background: Chitosan-gelatin-based thermosensitive hydrogel containing 5FU-alginate nanoparticles was formulated for the effective and sustained delivery of 5FU to skin. (2) Methods: Alginate, a polysaccharide used formulation using spray drying technique. Size, zeta potential, surface morphology were investigated zetasizer scanning electron microscope. The fabricated chitosan gelatin. Several important analyses characterize these prepared topical hydrogels. pH, visual transparency,...
Objectives: This research aimed to overcome challenges posed by cefepime excessive elimination rate and poor patient compliance developing transdermal delivery system using nano-transfersomes based chitosan gel.
The aim was to formulate and evaluate Gel/PVA hydrogels as a pH-sensitive matrix deliver methotrexate (MTX) colon. primed were subjected evaluation for swelling behavior, diffusion coefficient, sol-gel characteristic porosity using an acidic (pH 1.2) phosphate buffer (PBS) 6.8 & pH 7.4) media. Fourier transform infrared spectroscopy (FTIR) thermal gravimetric analysis (TGA) performed the chemical compatibility of hydrogel. shape alteration release hydrogel conducted at 1.2, 7.4. drug...
This project aims to synthesize and characterize the pH-sensitive controlled release of 5-fluorouracil (5-FU) loaded hydrogels (5-FULH) by polymerization acrylamide (AM) acrylic acid (AA) in presence glutaraldehyde (GA) as a crosslinker with ammonium persulphate an initiator. The formulation's code is named according (A1, A2, A3), (B1, B2, B3) (C1, C2, C3). optimized formulations were exposed various physicochemical tests, namely swelling, diffusion, porosity, sol gel analysis, attenuated...
This study attempted to develop and evaluate controlled-release matrix-type transdermal patches with different ratios of hydrophilic polymers (sodium carboxymethylcellulose hydroxypropyl methylcellulose) for the local delivery methotrexate. Transdermal were formulated by employing a solvent casting technique using blends sodium (CMC-Na) hydroxypropylmethylcellulose (HPMC) as rate-controlling agents. The F1 patch served control formulation 1:1 polymer concentration. F9 our optimized due...
In the present study, chitosan-decorated multiple nanoemulsion (MNE) was formulated using a two-step emulsification process. The nanoemuslion evaluated physiochemically for its size and zeta potential, surface morphology, creaming cracking, viscosity pH. A Franz diffusion cell apparatus used to carry out in vitro drug-release permeation studies. showed uniform droplet potential. pH of emulsion were range suitable topical delivery. drug contents simple (SNE), (CNE) MNE 71 ± 2%, 82 2% 90...
Oral bacterial infections are fairly common in patients with diabetes mellitus; however, due to limited treatment options, herbal medicines considered an alternate solution. This study aimed formulate a stable essential-oil-loaded nanoemulsion for the of oral infections. Essential oils from edible sources including coriander, clove, cinnamon and cardamom were extracted by hydrodistillation. The response surface methodology was used optimize formulation applying Box-Behnken design. oil...
(1) Background: The present study aimed to prepare chitosan-coated nanoemulsion gel containing 5-fluorouracil for enhanced topical delivery. (2) Methods: To formulate the gel, oleic acid was used as oil phase and Carbopol 940 a gelling agent. Chitosan coating agent control release of 5-FU. Drug−excipient compatibility evaluated using ATR-FTIR. prepared formulations were characterized based on particle size distribution, zeta potential, % encapsulation efficiency drug content. In vitro...
Methotrexate-loaded oil-in-water nanoemulsion formulations were prepared using the high shear homogenization technique. A drug excipient study (ATR-FTIR) was carried out to investigate compatibility between drug, polymers, and its admixtures. The thermal stability of evaluated by subjecting them a heating cooling cycle. (FNE1 FNE6) for particle size, PDI value, entrapment efficiency (EE). They analyzed morphological information transmission electron microscopy. (methotrexate)-loaded (FNE2,...
Despite being one of the most potent anticancer agents, cisplatin (CDDP) clinical usage is limited owing to acquired resistance and severe adverse effects including nephrotoxicity.
Letrozole (LTZ) is used as first-line treatment for hormone-positive breast cancer (BC) in postmenopausal women. However, its poor aqueous solubility and permeability have reduced clinical efficacy. Herein, we developed LTZ-nanotransferosomes (LTZ-NT) to address above mentioned issues. The LTZ-NT were optimized statistically using Design Expert
The purpose of the present study was to develop emulsions encapsulated by chitosan on outer surface a nano droplet containing 5-fluorouracil (5-FU) as model drug. were characterized in terms size, pH and viscosity evaluated for their physicochemical properties such drug release skin permeation vitro. tween 80 (T80), sodium lauryl sulfate, span 20, combination polyethylene glycol (PEG) T20 exhibited 88%, 86%, 90% 92%, respectively. Chitosan-modified considerably controlled 5-FU compared...
This study aims to develop chitosan-based voriconazole nanoparticles (NPs) using spray-drying technique. The effect of surfactants and polymers on the physicochemical properties, in vitro release, permeation NPs was investigated. prepared containing various (e.g., Tween 20 (T20), 80 (T80), sodium lauryl sulfate (SLS), propylene glycol (PG), Polyethylene glycol-4000 (PEG-4000)) were physiochemically evaluated for size, zeta potential, drug content, percent entrapment efficiency, across rats'...
Transdermal drug delivery systems (TDDSs) have become innovative, fascinating methods intended for skin application to achieve systemic effects. TDDSs overcome the drawbacks associated with oral and parenteral routes of administration. The current investigation aimed design, evaluate optimize methotrexate (MTX)-loaded transdermal-type patches having ethyl cellulose (EC) hydroxypropyl methyl (HPMC) at different concentrations local management psoriasis. In vitro release ex vivo permeation...
The study aimed to synthesize non-noxious, clean, reliable, and green sulfur nanoparticles (SNPs) from Citrus limon leaves. synthesized SNPs were used analyze particle size, zeta potential, UV–visible spectroscopy, SEM, ATR-FTIR. prepared exhibited a globule size of 55.32 ± 2.15 nm, PDI value 0.365 0.06, potential −12.32 0.23 mV. presence was confirmed by spectroscopy in the range 290 nm. SEM image showed that particles spherical with 40 ATR-FTIR no interaction, all major peaks preserved...
Nanoparticles are used increasingly for the treatment of different disorders, including burn wounds skin, due to their important role in wound healing. In this study, acriflavine-loaded poly (ε-caprolactone) nanoparticles (ACR-PCL-NPs) were prepared using a double-emulsion solvent evaporation method. All formulations and optimized by Box-Behnken design. Formulations evaluated effect independent variables, i.e., (PCL) amount (X1), stirring speed external phase (X2), polyvinyl alcohol (PVA)...