A5082187713- Advancements in Transdermal Drug Delivery
- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Nanoparticle-Based Drug Delivery
- Lipid Membrane Structure and Behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Toxin Mechanisms and Immunotoxins
- RNA Interference and Gene Delivery
- Tryptophan and brain disorders
- Graphene and Nanomaterials Applications
- Biochemical effects in animals
- Heme Oxygenase-1 and Carbon Monoxide
- Analytical Methods in Pharmaceuticals
- Essential Oils and Antimicrobial Activity
- Dermatology and Skin Diseases
- Autoimmune and Inflammatory Disorders Research
- Neonatal Health and Biochemistry
- Curcumin's Biomedical Applications
- Circadian rhythm and melatonin
- Research on Leishmaniasis Studies
- Eicosanoids and Hypertension Pharmacology
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Ocular Surface and Contact Lens
- Free Radicals and Antioxidants
Riphah International University
2017-2025
Hanyang University
2016-2025
Gachon University
2022-2024
Shaheed Benazir Bhutto University
2022-2023
Pakistan Institute of Medical Sciences
2019-2020
Nanjing Agricultural University
2014
The aim of this study is to investigate methotrexate-entrapped ultradeformable liposomes (MTX-UDLs) for potential transdermal application. MTX-UDLs were prepared by extrusion method with phosphatidylcholine as a bilayer matrix and sodium cholate or Tween 80 an edge activator. physicochemical properties determined in terms particle size, polydispersity index, zeta potential, entrapment efficiency. deformability was compared that conventional (MTX-CLs) using steel pressure filter device. skin...
Skin as a delivery route for drugs has attracted great attention in recent decades it avoids many of the limitations oral and parenteral administration. However, excellent barrier property skin is major obstacle effective transport through this route. The topmost layer skin, “stratum corneum” tightest one responsible most resistance offered. This necessitates breaching stratum corneum reversibly transiently order to achieve therapeutically meaningful level systemic circulation or local skin....
Nanomaterials have found extensive biomedical applications in the past few years because of their small size, low molecular weight, larger surface area, enhanced biological, and chemical reactivity. Among these nanomaterials, nanogels (NGs) are promising drug delivery systems composed cross-linked polymeric nanoparticles ranging from 100 to 200 nm. NGs represent an innovative zone research with speedy developments taking place on a daily basis. An incredible amount focus is placed...
The purpose of this study was to develop novel carbopol-based miltefosine-loaded transfersomal gel (HePCTG) for the treatment cutaneous leishmaniasis (CL) via efficient targeting leishmania infected macrophages.Miltefosine-loaded transfersomes (HePCT) were prepared by ethanol injection method followed their incorporation into carbopol form HePCTG. HePCT assessed physicochemical properties including mean particle size, polydispersity index, zeta potential, entrapment efficiency, morphology,...
Hepatocellular carcinoma (HCC) is a very aggressive and deadly disease associated with complicated tumor microenvironment (TME). Recently, lenvatinib (LEN) has shown remarkable clinical effectiveness in the treatment of HCC,...
The aim of this study was to develop docetaxel-incorporated lipid nanoparticles (DTX-NPs) improve the pharmacokinetic behaviour docetaxel (DTX) after oral and parenteral administration via sustained release. DTX-NPs were prepared by nanotemplate engineering technique with palmityl alcohol as a solid Tween-40/Span-40/Myrj S40 surfactants mixture. Spherical below 100 nm successfully narrow particle size distribution, 96% incorporation efficiency 686 times increase in DTX solubility. showed...
Ischemic strokes are categorized by permanent or transient obstruction of blood flow, which impedes delivery oxygen and essential nutrients to brain. In the last decade, therapeutic window for tPA has increased from 3 5-6 h, a new technique, involving mechanical removal clot (endovascular thrombectomy) allow reperfusion injured area, is being used more often. This approach can be done until 24 h after stroke onset. Due this fact, acute ischemic patients now recanalized, so tMCAO probably...
Ischemic stroke is characterized by permanent or transient obstruction of blood flow, which initiates a cascading pathological process, starting from acute ATP loss and ionic imbalance to subsequent membrane depolarization, glutamate excitotoxicity, calcium overload. These initial events are followed neuroinflammation oxidative stress, eventually causing neuronal neurosis apoptosis. Complicated interplays exist between these steps happening across various stages, not only represent the...
Ischemic stroke is categorized by either permanent or transient blood flow obstruction, impeding the distribution of oxygen and essential nutrients to brain. In this study, we examined neuroprotective effects compound A3, a synthetic polyphenolic drug product, against ischemic brain injury employing an animal model middle cerebral artery occlusion (p-MCAO). induced significant elevation in levels reactive species and, ultimately, provoked inflammatory cascade. Here, demonstrated that A3...
Background. Chemotherapeutic drugs cause severe toxicities if administered unprotected, without proper targeting, and controlled release. In this study, we developed topotecan- (TPT-) loaded solid lipid nanoparticles (SLNs) for their chemotherapeutic effect against colorectal cancer. The TPT-SLNs were further incorporated into a thermoresponsive hydrogel system (TRHS) (TPT-SLNs-TRHS) to ensure control release reduce toxicity of the drug. Microemulsion technique cold method were,...
Background: The purpose of this study was to investigate the suitability nanostructured lipid carriers (NLCs) loaded with miltefosine (HePC) as an anticancer drug for treatment breast cancer. Methods: HePC-NLCs were prepared using a microemulsion technique and then evaluated particle size, polydispersity index (PDI), incorporation efficiency, in vitro release entrapped drug, hemolytic potential. Furthermore, pharmacokinetic, biodistribution, liver toxicity analyses performed Sprague–Dawley...