A5008389888- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Mercury impact and mitigation studies
- Neuroscience and Neuropharmacology Research
- Eicosanoids and Hypertension Pharmacology
- Genomics, phytochemicals, and oxidative stress
- Pharmacological Receptor Mechanisms and Effects
- Gastroesophageal reflux and treatments
- Phytochemistry and biological activity of medicinal plants
- Advanced Drug Delivery Systems
- Curcumin's Biomedical Applications
- Melanoma and MAPK Pathways
- Ion Transport and Channel Regulation
- Traditional Chinese Medicine Analysis
- Pharmacological Effects of Natural Compounds
- Medicinal Plants and Neuroprotection
- Organoselenium and organotellurium chemistry
- NF-κB Signaling Pathways
- Heavy Metal Exposure and Toxicity
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Essential Oils and Antimicrobial Activity
- Chemokine receptors and signaling
- Circadian rhythm and melatonin
- Mast cells and histamine
International Islamic University, Islamabad
2024-2025
Riphah International University
2019-2023
Shenzhen Children's Hospital
2021
Peking University
2020
Ischemic stroke is categorized by either permanent or transient blood flow obstruction, impeding the distribution of oxygen and essential nutrients to brain. In this study, we examined neuroprotective effects compound A3, a synthetic polyphenolic drug product, against ischemic brain injury employing an animal model middle cerebral artery occlusion (p-MCAO). induced significant elevation in levels reactive species and, ultimately, provoked inflammatory cascade. Here, demonstrated that A3...
Epilepsy is a neurodegenerative brain disorder characterized by recurrent seizure attacks. Numerous studies have suggested strong correlation between oxidative stress and neuroinflammation in several disorders including epilepsy. This study aimed at investigating the neuroprotective effects of natural compound carveol against pentylenetetrazole- (PTZ-) induced kindling model. Two different doses (10 mg/kg 20 mg/kg) were administered to male rats determine effective dose further demonstrate...
Stroke is the leading cause of morbidity and mortality worldwide. About 87% stroke cases are ischemic, which disrupt physiological activity brain, thus to a series complex pathophysiological events. Despite decades research on neuroprotectants probe for suitable therapies against ischemic stroke, no successful results have been obtained, new alternative approaches urgently required in order combat this pathological torment. To address these problems, drug repositioning/reprofiling explored...
Purpose: Melatonin and celecoxib are antioxidants anti-inflammatory agents that exert protective effects in different experimental models. In this study, the neuroprotective of melatonin were demonstrated against ethanol-induced neuronal injury by silico, morphological, biochemical approaches. Methods: For silico 3-D structures constructed docking analysis performed. vivo studies, rats treated with ethanol, melatonin, celecoxib. Brain samples collected for morphological analysis. Results:...
Neuropathic pain has been characterized as chronic resulting from pathological damage to the sensorimotor system. Because of its complex nature, it remains refractory most therapeutic interventions, and surgical intervention physiotherapy alongside steroidal treatments remain only treatment protocols with limited success, hence solidifying need find efficacious alternatives. Emodin was used a post-treatment for potential be neuroprotective in constriction injury-induced NP. The first day...
Stress-associated kinases are considered major pathological mediators in several incurable neurological disorders. Importantly, among these stress kinases, the c-Jun NH2-terminal kinase (JNK) has been linked to numerous neuropathological conditions, including oxidative stress, neuroinflammation, and brain degeneration associated with injuries such as ischemia/reperfusion injury. In this study, we adopted a drug repurposing/reprofiling approach explore novel JNK3 inhibitors from FDA-approved...
Rosa webbiana L. (Rosaceae) is one of the least reported and most understudied members this family. It native to Himalayan regions Pakistan Nepal. The anti-convulsant effect n-hexane extract fruit was investigated in a pentylenetetrazole (PTZ)-induced animal model epilepsy. Male Sprague-Dawley rats were divided into six groups (n = 7) including control, PTZ (40 mg/kg), diazepam (4 mg/kg) (at 50, 150 300 mg/kg). Convulsive behavior observed resultant seizures scored, animals sacrificed their...
Background: Epilepsy is a common neurological disorder that characterized by recurrent episodes of seizures. Various studies have demonstrated direct association between oxidative stress and inflammation in several disorders including epilepsy. This study aimed to investigate the neuroprotective effects synthetic 1,3,4, oxadiazole compound A3 against pentylenetetrazole (PTZ)-induced kindling seizure model. Methodology: PTZ was administered sub-convulsive dose 40 mg/kg for 15 days, at 48-hour...
Major depressive disorder (MDD) is a progressive deteriorating mental state with feeling of worthlessness and frequent mood swings. Several studies reported the favorable effects natural drug substances on MMD associated oxidative stress neuroinflammation. The present study attempted to examine whether carveol could affect lipopolysaccharide- (LPS-) induced depression, if so, how nuclear factor E2-related (Nrf2) contributed neuroprotective mechanistically. Two experimental cohorts were used...
Background: Pain and inflammation are complex biological mechanisms often associated with sensory, emotional, cognitive discomfort resulting from tissue damage. Traditional medicine frequently employs medicinal plants for managing these conditions due to the adverse effects conventional drugs. Ducrosia anethifolia, a plant native Balochistan, Pakistan, is traditionally used its analgesic anti-inflammatory properties.Objective: This study aimed evaluate acute toxicity, analgesic, of...