A5102022428- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Ischemic Stroke Management
- Atrial Fibrillation Management and Outcomes
- Cancer-related molecular mechanisms research
- Venous Thromboembolism Diagnosis and Management
- Cerebrovascular and Carotid Artery Diseases
- Inflammatory mediators and NSAID effects
- MicroRNA in disease regulation
- Lipoproteins and Cardiovascular Health
- Microbial Natural Products and Biosynthesis
- Circular RNAs in diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Child Nutrition and Feeding Issues
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Diabetes Treatment and Management
- Eicosanoids and Hypertension Pharmacology
- Sarcoma Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Alcohol Consumption and Health Effects
- Wnt/β-catenin signaling in development and cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Bone Tumor Diagnosis and Treatments
- Nanoplatforms for cancer theranostics
- Infant Nutrition and Health
- Genomics and Phylogenetic Studies
Ruian People's Hospital
2014-2025
Wenzhou Medical University
2014-2025
Shanghai Institute of Organic Chemistry
2011-2024
University of Chinese Academy of Sciences
2024
Qinghai University Affiliated Hospital
2024
Chongqing Medical University
2024
Sichuan Agricultural University
2019-2023
Nanjing Institute of Geography and Limnology
2023
Zhejiang University of Science and Technology
2023
Zhejiang Sci-Tech University
2023
Abstract Abnormal activation of the gut mucosal immune system and a highly dysregulated microbiota play essential roles in progression inflammatory bowel disease (IBD). The clinical treatment IBD remains challenging, with first‐line drugs showing limited efficacy significant side effects. A reactive oxygen species (ROS)‐activated CO versatile nanomedicine (CMPs) capable remodeling immune‐microbiota microenvironment via potent anti‐oxidant, anti‐inflammatory, antimicrobial effects is...
Load bearing/energy storage integrated devices (LEIDs) allow using structural parts to store energy, and thus become a promising solution boost the overall energy density of mobile systems, such as electric cars drones. Herein, with new high-strength solid electrolyte, we prepare practical high-performance load-bearing/energy electrochemical capacitors excellent mechanical strength (flexural modulus: 18.1 GPa, flexural strength: 160.0 MPa) high ability (specific capacitance: 32.4 mF cm-2,...
Abstract Abnormal activation of the intestinal mucosal immune system, resulting from damage to barrier and extensive invasion by pathogens, contributes pathogenesis inflammatory bowel disease (IBD). Current first‐line treatments for IBD have limited efficacy significant side effects. An innovative H 2 S‐releasing montmorillonite nanoformulation (DPs@MMT) capable remodeling homeostasis, repairing barrier, modulating gut microbiota is developed electrostatically adsorbing diallyl...
Abstract The abnormal expression of long noncoding RNAs (lncRNAs) plays an important role in the regulation human cancer progression and drug resistance. lncRNA OPI5‐AS1 is a crucial regulator some cancers; however, its cisplatin resistance osteosarcoma remains unclear. We found that OIP5‐AS1 was significantly upregulated cisplatin‐resistant (CR) cells MG63‐CR SaOS2‐CR compared with corresponding parental cells. silencing suppressed cell growth vitro vivo, promoted apoptosis cells,...
Introduction: Gypenoside is a natural extract of Gynostemma pentaphyllum (Thunb.) Makino, plant in the Cucurbitaceae family. It has been reported to have antitumor effects on proliferation, migration and apoptosis various types cancer cells. However, use gypenoside treatment gastric not studied. In present study, we explored therapeutic effect potential molecular mechanism. Methods Results: Our results showed that induced HGC-27 SGC-7901 cells time-dependent dose-dependent manner. Network...
Abstract Disruption of the intestinal epithelial barrier, driven by imbalances in gut mucosal immunity and microbial homeostasis, is central to onset progression inflammatory bowel disease (IBD). This study introduces a CO‐releasing polyoxometalates (POMs) nanozyme (PMC), synthesized coordinating pentacarbonyl manganese bromide with molybdenum‐based POM nanoclusters. PMC demonstrates targeted accumulation at IBD‐affected sites, efficient scavenging reactive oxygen species (ROS), responsive...
The progression of osteoarthritis (OA) is closely linked to synovial inflammation caused by an imbalance between M1 and M2 macrophages. To tackle this problem, we developed a liposome responsive reactive oxygen species (ROS), modified with folic acid ligands target M1-polarized macrophages, loaded the anti-inflammatory agent dimethyl fumarate (DMF). This liposome-based drug delivery system was designed reprogram macrophage phenotype remodel inflammatory microenvironment in joint cavity...
The relationship between high plasma 20-hydroxyeicosatetraenoic acid (20-HETE) levels and neurological deterioration (ND) has not been investigated in patients with acute minor ischemic stroke.We conducted a prospective, multicenter observational study stroke. Plasma of 20-HETE were measured at admission all patients. primary end point the was ND within 10 days after admission. degree disability assessed using modified Rankin scale 3 months admission.A total 322 enrolled, which 85 (26.4%)...
Ischemic stroke is characterized by permanent or transient obstruction of blood flow, which initiates a cascading pathological process, starting from acute ATP loss and ionic imbalance to subsequent membrane depolarization, glutamate excitotoxicity, calcium overload. These initial events are followed neuroinflammation oxidative stress, eventually causing neuronal neurosis apoptosis. Complicated interplays exist between these steps happening across various stages, not only represent the...
Introduction To investigate the prevalent of aspirin resistance (AR) in Chinese stroke patients and its association with recurrent other vascular events, including cardiovascular disease death. Methods We prospectively enrolled 634 patients. Aspirin was administrated to every patient from first day admission. Whole blood samples were collected for platelet aggregation testing after administered 7–10 days. A follow-up period 12–24 months performed record events hemorrhagic side effects....
FR901464, an antitumor natural product, represents a new class of potent anticancer small molecules targeting spliceosome and inhibiting both splicing nuclear retention pre-mRNA. Herein we describe the biosynthetic gene cluster identified by degenerate primer PCR amplification encoding 3-hydroxy-3-methylglutaryl-CoA synthase (HCS) postulated to be involved in biosynthesis β-branched polyketide from Pseudomonas sp. No. 2663. This consists twenty open reading frames (ORFs) was localized 93-kb...
Sorafenib is widely used for treatment of hepatocellular carcinoma (HCC), but the acquired resistance remains a major obstacle its application. Thus it critical importance to elucidate molecular mechanisms underlying sorafenib in HCC. This study aimed determine roles long noncoding RNA SNHG16 sorafenib-resistant HCC cells.HCC and matched adjacent normal liver tissue samples were obtained from 103 patients. Sorafenib-resistant HepG2/SOR cell line was established parental HepG2 cells by...
The objective of this study was to determine the effects increased AA and energy intake during late gestation on reproductive performance, milk composition, metabolic redox status sows. A total 118 Yorkshire sows (third through sixth parity) were randomly assigned dietary treatments from day 90 until farrowing. Dietary consisted combinations 2 standardized ileal digestible (SID) levels [14.7 or 20.6 g/d SID Lys, Lys other met exceeded NRC (2012) recommendations] (28.24 33.78 MJ/d NE) in a ×...
This study was designed to develop a nomogram for assessing the survival of patients with Ewing sarcoma (ES).Data from diagnosed ES between 2004 and 2013 were collected Surveillance, Epidemiology, End Results (SEER) database. Based on patient registration, primary cohort divided into training set (n = 479, data 17 cancer registries) validation 137, 1 registry). Then, prognostic effects variables analyzed using Kaplan-Meier method Cox proportional hazard model. Moreover, nomograms established...
Abstract We aimed to investigate the biological function of MELK and therapeutic potential OTSSP167 in human bladder cancer (BCa). First, we observed overexpression BCa cell lines tissues found that it was associated with higher tumour stage grade, which consistent transcriptome analysis. High expression significantly correlated poor prognosis patients, have a role cycle, G1/S transition mitosis, DNA repair replication. Furthermore, cells presented decreased proliferation capacity following...
Significance Enzymatic modifications of anthracycline antibiotics are urgently needed in the fields biosynthesis, biocatalysis, and even medical chemistry. However, neither hydroxyl regioisomerization nor dehydroxylation core was described previously. Here, we discover an unprecedented process biosynthesis a rare carbon-4 deoxyanthracycline, which includes three tailoring steps performed by four-enzyme cascade: two-component hydroxylases mediated cryptic hydroxylation, two NmrA-like...
Abstract Soft tissue sarcoma (STS) of the extremities are a rare tumor. Metastases develop in about 40%-50% patients, most whom die from their disease. We sought to identify potential risk factors associated with metastatic diseases upon presentation for patients STS and established reliable nomogram model predict distant metastasis at presentation. The current study retrospectively analyzed 3884 or trunk Surveillance, Epidemiology, End Results (SEER) database between 2010 2015. Based on...
This study aimed to investigate the effects of long-term maternal intake inulin on intestinal morphology, permeability, inflammation and microbiota offspring rats treated with dextran sulfate sodium (DSS). Sixteen female adult Sprague-Dawley were assigned two groups receiving fiber-free diet (FFD) or (INU, 5% inulin) for three parities. The weaned (third-parity) fed same four weeks until 6% DSS 7 days; as follows: FFD, FFD + DSS, INU DSS. results showed that increased histopathology score...