A5100343339- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Viral Infections and Vectors
- Long-Term Effects of COVID-19
- Rabies epidemiology and control
- Monoclonal and Polyclonal Antibodies Research
- Viral gastroenteritis research and epidemiology
- Pneumonia and Respiratory Infections
- Bacillus and Francisella bacterial research
- Viral Infections and Outbreaks Research
- Animal Virus Infections Studies
- Antimicrobial Resistance in Staphylococcus
- COVID-19 Impact on Reproduction
- Streptococcal Infections and Treatments
- Gastric Cancer Management and Outcomes
- Poxvirus research and outbreaks
- Respiratory viral infections research
- Viral Infections and Immunology Research
- Immunotherapy and Immune Responses
- SARS-CoV-2 detection and testing
- vaccines and immunoinformatics approaches
- Microbial infections and disease research
- Bacterial Infections and Vaccines
- Neonatal and Maternal Infections
- Immune cells in cancer
Wenzhou Medical University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
Nanjing Medical University
2023-2024
Academy of Military Medical Sciences
2024
Huazhong University of Science and Technology
2014-2023
Central Hospital of Wuhan
2014-2023
Xiamen University
2023
First Affiliated Hospital of Nanchang University
2020-2023
Nanchang University
2020-2023
Minzu University of China
2023
Background Thrombocytopenia has been implicated in patients infected with severe acute respiratory syndrome coronavirus 2, while the association of platelet count and changes subsequent mortality remains unclear.
Monkeypox is a poorly described emerging zoonosis endemic to Central and Western Africa.Using surveillance data from Tshuapa Province, Democratic Republic of the Congo during 2011-2015, we evaluated differences in incidence, exposures, clinical presentation polymerase chain reaction-confirmed cases by sex age.We report 1057 confirmed cases. The average annual incidence was 14.1 per 100 000 (95% confidence interval, 13.3-15.0). higher male patients (incidence rate ratio comparing males...
The role of tumor-resident microbiota in modulating tumor immunity remains unclear. Here, we discovered an abundance intra-tumoral bacteria, such us E.coli, residing and resulting Colorectal cancer liver metastasis (CRLM). E.coli enhanced lactate production, which mediated M2 macrophage polarization by suppressing nuclear factor-κB -gene binding (NF-κB) signaling through retinoic acid-inducible gene 1 (RIG-I) lactylation. Lactylation RIG-I suppressed recruitment NF-κB to the Nlrp3 promoter...
Abstract Using China’s national surveillance data on hand, foot and mouth disease (HFMD) for 2008–2015, we described the epidemiologic virologic features of recurrent HFMD. A total 398,010 patients had HFMD recurrence; 1,767 1,814 cases laboratory-confirmed HFMD: 99 reinfections enterovirus A71 (EV-A71) with EV-A71, 45 coxsackievirus A16 (CV-A16) CV-A16, 364 other enteroviruses enteroviruses, 383 EV-A71 CV-A16 923 or CV-A16. The probability recurrence was 1.9% at 12 months, 3.3% 24 3.9% 36...
Abstract First discovered in rural areas of middle-eastern China 2009, severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne zoonosis affecting hundreds cases reported each year. Using the national surveillance data from 2010 to 2013, we conducted this retrospective epidemiological study and risk assessment SFTS China. We found that incidence its epidemic are continuing grow, but case fatality rate (CFR) has steadily decreased. most commonly affected elderly farmers...
SARS-CoV-2 causing the worldwide pandemic has changed people's life in multiple aspects dramatically since it's first identified Wuhan, China at end of 2019. While numbers infected patients and death toll keep vigorous increasing, curbing progression is an urgent goal. Efforts have been made to search for prophylactic therapeutic approaches including neutralizing antibodies development. By reviewing dozens studies on anti-spike identification, we concluded that (1) promising are being fished...
Abstract Disruption of the intestinal epithelial barrier, driven by imbalances in gut mucosal immunity and microbial homeostasis, is central to onset progression inflammatory bowel disease (IBD). This study introduces a CO‐releasing polyoxometalates (POMs) nanozyme (PMC), synthesized coordinating pentacarbonyl manganese bromide with molybdenum‐based POM nanoclusters. PMC demonstrates targeted accumulation at IBD‐affected sites, efficient scavenging reactive oxygen species (ROS), responsive...
Summary Background Coronavirus infectious disease 2019 (COVID-19) has developed into a global pandemic. It is essential to investigate the clinical characteristics of COVID-19 and uncover potential risk factors for severe reduce overall mortality rate COVID-19. Methods Sixty-one critical patients admitted intensive care unit (ICU) 93 non-ICU at Huoshenshan Hospital (Wuhan, China) were included in this study. Medical records, including demographic, platelet counts, heparin-involved...
Background Rabies in China remains a public health problem. In 2014, nearly one thousand rabies-related deaths were reported while rabies geographic distribution has expanded for the recent years. This report used surveillance data to describe epidemiological characteristics of human including determining high-risk areas and seasonality support national prevention control activities. Methods We analyzed incidence cases mainland using notifiable from 1960–2014, which includes detailed...
Abstract Background COVID-19 has posed an enormous threat to public health around the world. Some severe and critical cases have bad prognoses high case fatality rates, unraveling risk factors for are of significance predicting preventing illness progression, reducing rates. Our study focused on analyzing characteristics exploring developing COVID-19. Methods The data this was disease surveillance symptomatic reported from 30 provinces in China between January 19 March 9, 2020, which...
In this study, we investigate the seroprevalence of SARS-CoV-2 antibodies among blood donors in cities Wuhan, Shenzhen, and Shijiazhuang China. From January to April 2020, 38,144 healthy three were tested for total antibody against followed by pseudotype neutralization tests, IgG, IgM testing. Finally, a 398 confirmed positive. The age- sex-standardized 18-60 year-old adults (18-65 Shenzhen) was 2.66% (95% CI: 2.24%-3.07%) 0.033% 0.0029%-0.267%) 0.0028% 0.0001%-0.158%) Shijiazhuang,...
Coronavirus disease 2019 (COVID-19) is a health emergency worldwide, and gastrointestinal (GI) symptoms are increasingly reported in COVID-19 patients. However, sample size was small the incidence of GI patients variable across studies, correlation between these clinical outcomes remains incompletely understood. The objective this study to compare characteristics with without admitted Jianghan Fangcang Shelter Hospital Wuhan. This retrospective recruited 1320 hospital from 5 February 2020 9...
COVID-19 has been a global health threat. We aimed to investigate the nutrition status of patients and evaluate prognostic value controlling nutritional (CONUT) score in these patients. 348 severe with were collected. Based on CONUT score, 161 (46.3%) had mild malnutrition while 139 (39.9%) moderate-severe malnutrition. Compared normal groups, group older, more male, higher counts white blood cell neutrophil as well serum levels C-reactive protein. Nearly half (44.6%) developed acute cardiac...
Abstract OBJECTIVE To describe rabies and rabies-related events occurring during 2016 in the United States. DESIGN Observational study based on passive surveillance data. ANIMALS All animals submitted for testing States 2016. PROCEDURES State territorial public health programs provided data Data were analyzed temporally geographically to assess trends domestic sylvatic animal cases. RESULTS During 2016, 50 states Puerto Rico reported 4,910 rabid CDC, representing a 10.9% decrease from 5,508...
Background and Purpose: No studies have reported the effect of coronavirus disease 2019 (COVID-19) epidemic on patients with preexisting stroke. We aim to study clinical course COVID-19 stroke investigate death-related risk factors. Methods: consecutively included 651 adult inpatients from Central Hospital Wuhan between January 2 February 15, 2020. Data demography, comorbidities, manifestations, laboratory findings, treatments, complications, outcomes (ie, discharged or death) participants...
Background SFTS virus (SFTSV) is a newly discovered pathogen to cause severe fever with thrombocytopenia syndrome (SFTS) in human. Successful control of SFTSV epidemic requires better understanding the antigen target humoral immune responses new bunyavirus infection. Methodology/Principal Findings We have generated combinatorial Fab antibody phage library from two patients recovered To date, 94 unique human antibodies been and characterized over 1200 clones obtained by screening purified...
ObjectivesThis study intended to investigate the dynamics of anti-spike (S) IgG and IgM antibodies in COVID-19 patients.MethodsAnti-S IgG/IgM was determined by a semi-quantitative fluorescence immunoassay plasma patients at manifestation rehabilitation stages. The immunoreactivity full-length S proteins, C-terminal domain (CTD), N-terminal (NTD) S1 fragments were an ELISA assay. Clinical properties admission discharge collected simultaneously.ResultsThe positive rates anti-S elevated after...
Neutralizing antibodies in the subjects of an inactivated SARS-CoV-2 vaccine clinical trial showed a decreasing trend over months. An investigation studying third immunization suggested that waning neutralizing individuals administered two doses does not mean disappearance immunity.