A5085153524- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Respiratory viral infections research
- Vaccine Coverage and Hesitancy
- Animal Virus Infections Studies
- Virology and Viral Diseases
- Acute Ischemic Stroke Management
- Cardiac Arrhythmias and Treatments
- Immunodeficiency and Autoimmune Disorders
- Biotechnology and Related Fields
- Atrial Fibrillation Management and Outcomes
- Cytokine Signaling Pathways and Interactions
- Breast Lesions and Carcinomas
- interferon and immune responses
- Viral Infections and Vectors
- Immune responses and vaccinations
- Mosquito-borne diseases and control
- Breast Implant and Reconstruction
- Atherosclerosis and Cardiovascular Diseases
- Vector-borne infectious diseases
- Breast Cancer Treatment Studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Biomedical and Engineering Education
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2025
Peking University
2017-2019
Abstract Background We evaluated an inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine for immunogenicity and safety in adults aged 18–59 years. Methods In this randomized, double-blinded, controlled trial, healthy received a medium dose (MD) or high (HD) of the at interval either 14 days 28 days. Neutralizing antibody (NAb) anti-S anti-N antibodies were detected different times, adverse reactions monitored after full immunization. Results A total 742 enrolled...
The identification of poliovirus in stool samples post-Oral Poliovirus Vaccine (OPV) immunization is essential for implementing post-eradication monitoring poliomyelitis. This research presents the inaugural assessment virus shedding rate and genetic diversity OPV strains across different Inactivated (IPV)-OPV sequential schedules. Our findings revealed that serotypes each groups peaked within 7 days following initial administration OPV, then gradually decreased. Prior vaccination with...
Background This study was conducted to describe present and changing trends in surgical modalities neoadjuvant chemotherapy (NACT) female breast cancer patients China from 2006 2015. Methods Data of 44 299 15 tertiary hospitals Beijing were extracted hospitalization summary reports. Surgeries categorized into five modalities: breast‐conserving surgery (BCS), simple mastectomy (SM), modified radical (MRM), (RM), extensive (ERM). Results In total, 38 471 (86.84%) underwent surgery: 22.64% BCS,...
Adherence to oral anticoagulants is crucial for the prevention of ischemic stroke in atrial fibrillation patients; however, evidence oral-anticoagulant adherence from developing countries still lacking. This study aimed evaluate current situation and predictors non-valvular (NVAF) patients China.Records NVAF were obtained a regional claims database. Both initiation calculated linked records. Factors identified using Cox regression.Among 33,463 patients, only 13.9% initialized warfarin...
Abstract BACKGROUND In-depth investigations of the safety and immunogenicity inactivated SARS-CoV-2 vaccines are needed. METHOD In a phase I randomized, double-blinded, placebo-controlled trial involving 192 healthy adults 18-59 years age, two injections three different doses (50 EU, 100 EU 150 EU) an vaccine or placebo were administered intramuscularly with 2- 4-week interval between injections. The evaluated within 28 days. FINDING this study, 191 subjects assigned to groups group...
To investigate whether the TNF-α, IL-2, IL-4 and IL-10 genes contribute to variations in vaccine-induced immune responses after immunization with inactivated Japanese encephalitis vaccine (IJEV), a total of 369 individuals who received IJEV were enrolled. Based on virus (JEV) neutralization antibodies (NAbs), divided into seropositive (SP) seronegative (SN) groups. Then, 17 SNPs genotyped using TaqMan method. Although there was no association JEV seropositivity triggered by vaccination when...
Abstract Trivalent oral poliovirus vaccine (tOPV) has been withdrawn and instead an inactivated (IPV) bivalent type 1 3 OPV (bOPV) sequential immunization schedule implemented since 2016, but no immune persistence data are available for this polio vaccination strategy. This study aimed to assess following different schedules. Venous blood was collected at 24, 36, 48 months of age from participants who had completed schedules combined IPV in phase III clinical trials. The serum neutralizing...
Mumps vaccine immunizations have reduced the incidence of this disease. With variation mumps circulating strain, novel strains are always important.A 2-center parallel, randomized, double-blind noninferiority trial was performed to compare an F-genotype attenuated (SP strain) A-genotype (S-79, Jeryl-Lynn in 1080 healthy children aged 8-24 months Hubei, China.Participants were randomly assigned receive a high or low dose SP S79 and then assessed clinically at 30 minutes 1-28 days...
Aims: To discover possible relationships between CXCL12 single nucleotide polymorphisms (SNPs) and type 2 diabetes mellitus (T2DM) its risk factors. Methods: The present sib-pair study was conducted in a rural community of Beijing, China. SNPs rs2297630, rs1746048, rs1801157 located within or nearby the gene were genotyped using allele-specific polymerase chain reaction method. Haseman-Elston regression used to investigate linkages these T2DM. A generalized estimating equation logistic model...
Background: An inactivated poliomyelitis vaccine made from Sabin strains (sIPVs) has widely been used in China since 2015. However, the quantitative data on instant and persistent inhibition effects of maternal poliovirus antibodies immune response to sIPV priming booster vaccination have not available yet. Objective: In this study, we aim explore quantify effect elicited by primary vaccination. Methods: The immunogenicity consisting days 0 30 after prime a phase IV trial were pooled for...
There has been no data on the immunogenicity and safety of 4
Objective To provide references for future government science and technology plan on providing projects the research development of new vaccine products. Methods Through analyzing various vaccines that have gained from plan, this paper summarizes types projects, funding proportion characteristics at national, provincial municipal level different stages. Results In general, supporting categories levels are clear. Each stage products has corresponding planning which closely linked...