A5102836417- Hepatitis B Virus Studies
- Vaccine Coverage and Hesitancy
- Virology and Viral Diseases
- Respiratory viral infections research
- Influenza Virus Research Studies
- Viral gastroenteritis research and epidemiology
- COVID-19 epidemiological studies
- Viral Infections and Immunology Research
- Immune responses and vaccinations
- Hepatitis Viruses Studies and Epidemiology
- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- Hepatitis C virus research
- Protein Hydrolysis and Bioactive Peptides
- Viral Infections and Outbreaks Research
- Peripheral Neuropathies and Disorders
- Viral Infections and Vectors
- Liver Disease Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Probiotics and Fermented Foods
- Global Maternal and Child Health
- Vector-borne infectious diseases
- Infection Control and Ventilation
- COVID-19 and healthcare impacts
- Poxvirus research and outbreaks
Tongji University
2023
Chinese Center For Disease Control and Prevention
2011-2023
Zhejiang Marine Fisheries Research Institute
2021-2022
Zhejiang University of Technology
2021-2022
Guangdong Provincial Center for Disease Control and Prevention
2012-2022
Key Laboratory of Guangdong Province
2020
Guangzhou Center for Disease Control and Prevention
2009-2020
Fuzhou University
2019
Centers for Disease Control and Prevention
2014-2015
Southwest Hospital
1993
The intestinal flora is recognized as a significant contributor to the immune system. In this research, protective effects of oyster peptides on regulation and microbiota were investigated in mice treated with cyclophosphamide. results showed that restored indexes thymus, spleen liver, stimulated cytokines secretion promoted relative mRNA levels Th1/Th2 (IL-2, IFN-γ, IL-4 IL-10). Occludin, Claudin-1, ZO-1, Mucin-2 up-regulated, NF-κB signaling pathway was also activated after administration....
Abstract Background Pertussis is a reported vaccine-preventable respiratory disease in China. Because the routine laboratory methods for diagnosis are not use, cases mainly infants with classical paroxysmal cough and true incidence related to pertussis most likely under estimated. In China, however, few studies have attempted address this issue. The purpose of cross sectional study was estimate rates using method sero-epidemiology immunoglobulin (Ig) G antibodies against toxin (PT) among...
Guangdong province attracted more than 31 million migrants in 2010. But few studies were performed to estimate the complete and age-appropriate immunization coverage determine risk factors of migrant children. 1610 children aged 12–59 months from 70 villages interviewed Guangdong. Demographic characteristics, primary caregiver's knowledge attitude toward immunization, child's history obtained. UTD rates for following five vaccines overall series (1:3:3:3:1 series) assessed: one dose BCG,...
Herpes zoster (HZ) exists widely in China and most cases occur among old people, but no epidemiology information of HZ was available. We aimed to investigate the characteristics adults aged 50 over Guangdong, China. A total 34 counties/districts were randomly selected 7149 residents investigated by local CDC professionals using accidental sampling method. There 247 respondents having had before; lifetime prevalence people above study area 3.46%. The females higher than that males. Pearl...
Guangdong province of China is HBV high endemicity and 1.6 million neonates are administrated 5 μg yeast recombinant anti-HBV vaccine each year. But few studies performed to evaluate the immunogenicity revaccination effect on non- low- responders.2,199 children were administered intramuscularly with at 0, 1 6 mo after birth. A 3 ml blood sample was drawn from infant third dose for determination anti-HBs level. Three additional doses (10 each) given responders.Of 1,814 subjects, 3.1%...
To compare the safety, immunogenicity and long-term effect of a purified vero cell cultured rabies vaccine in post-exposure subjects following 2 intramuscular regimens, Zagreb or Essen regimen.Serum samples were collected before vaccination on days 7, 14, 42, 180 365 post vaccination. Solicited adverse events recorded for 7 d each dose, unsolicited throughout entire study period. This was registered with ClinicalTrials.gov (NCT01821911 NCT01827917).No serious reported. Although regimen had...
To evaluate the impact of universal infant hepatitis B vaccination program on virus (HBV) infection in Guangdong Province, China.In 2006, a serosurvey was conducted Province among children aged <15 years, 14 years after introduction vaccination. The participants were selected by stratified, multi-stage random sampling. Demographic characteristics and history collected questionnaire review records, serum specimens tested for surface antigen (HBsAg), antibody to core (anti-HBc), (anti-HBs)...
A cross-sectional community prevalence survey was conducted to investigate the sero-epidemiological features of hepatitis B virus (HBV) infection among children aged 1-14 years in Guangdong Province 2013, and provide baseline data for evaluation HBV disease burden impacts control.A total 2765 from 16 villages/streets eight cities were recruited as subjects. blood sample obtained each subject. chemiluminescence microparticle immunoassay (CMIA) used detect surface antigen (HBsAg), antibody...
In this study, a novel peptide, AEYLCEAC with high angiotensin-I-converting enzyme inhibitory (ACEI) activity was screened from oyster (Crassostrea gigas) hydrolysates, which obtained simulated gastro-intestinal digestion. Candidate peptides were confirmed to have higher binding (ACE) than the positive drug phosphoinic tripeptide calculated by Discovery Studio, and showed highest ACE inhibition rate in vitro IC50 of 4.287 mM. Lineweaver-Burk plots that peptidic type is competitive. The...
Objectives To understand the incidence of outpatient influenza cases in a subtropical area China and associated economic burden on patients' families. Methods A hospital-based prospective study was conducted Zhuhai City during 2008–2009. All influenza-like illness (ILI) were identified 28 sentinel hospitals. representative sample throat swabs from ILI collected for virus isolation using Madin-Darby canine kidney cells. The estimated basis number patients detected by sites. telephone survey...
Background The disease burden associated with influenza in developing tropical and subtropical countries is poorly understood owing to the lack of a comprehensive surveillance system information-exchange mechanisms. impact on outpatient visits, hospital admissions, deaths has not been fully demonstrated date south China. Methods A time series Poisson generalized additive model was used quantitatively assess influenza-like illness (ILI) by using data Zhuhai City from 2007 2009, combined...
Under accelerated urbanization and high-intensity human activities, the natural wetlands distribution area (NWDA) in Minjiang River estuary faces great challenge of a deteriorative urban thermal environment.This work aims to analyze impact land use/land cover (LULC) on environment model wetland surface temperature disturbance characteristics during process urbanization.The study utilized following methodological steps: (1) mapping LULC spatial temporal through photo interpretation; (2)...
Abstract Background This study tested the hypothesis that immunogenicity and safety of simultaneous administration enterovirus 71 (EV71) vaccine (dose 1) with recombinant hepatitis B (HepB) on day 1 EV71 2) group A meningococcal polysaccharide (MenA) 30 is not inferior to separate each vaccine. Methods The was designed as a randomized, open-label, noninferiority trial. total 775 healthy infants aged 6 months were randomly assigned in ratio 1:1:1 receive HepB MenA (the SI group); doses 2 days...
Background Despite several immunization efforts, China saw a resurgence of measles in 2012. Monitoring transmissions individuals from different age groups could offer information that would be valuable for planning adequate disease control strategies. We compared the age-specific effective reproductive numbers (R) during 2009–2016 Guangdong, China. Methods estimated R values 7 groups: 0–8 months, 9–18 19 months to 6 years, 7–15 16–25 26–45 and ≥46 years adapting contact matrix The daily...
To estimate the disease burden and financial attributed to hepatitis B virus (HBV) infection in Guangdong Province. Based on data of incidence, mortality healthcare cost HBV-related diseases other socio-economic Province, we estimated deaths, disability-adjusted life-years (DALYs) economic for three diseases-hepatitis B, liver cirrhosis cancer-in following procedures developed global study. Then HBV was estimated. have caused 33,600 (95% confidence interval (CI): 29,300-37,800) premature...
Oyster peptide (OP) has exhibited useful biological activities and can be used in multi-functional foods. OP been reported to play a significant role intestinal protection, but its specific mechanism is still not completely understood. The aim of this study was analyze the potential effect on oxidative damage mice intestine induced by cyclophosphamide (Cy). experimental results revealed that intragastric administration significantly increased average bodyweight, improved ileum tissue...
Background: An active response to a rubella outbreak may interrupt disease transmission, and immunization (ORI) can increase immunity among persons who might otherwise not be protected. On March 17, 2014, was reported in middle school Guangzhou city, China. We conducted an investigation assess impact of policy exclusion cases from ORI.Methods: Active surveillance used find rubella. Investigators interviewed teachers reviewed the absentee records determine implementation details exclusion....
We describe the epidemiology of hepatitis B virus (HBV) infection among women reproductive age residing in areas China that are highly endemic for chronic HBV, and provide evidence useful decision-makers to guide strategies preventing mother-to-child transmission assess impact perinatal PMTCT by projecting HBsAg prevalence trends without interventions. conducted a cross-sectional HBV serological survey women, 15-49 years age, Fujian, Guangdong, Guangxi Hainan provinces. Demographic other...
The 2009 province-wide and 2010 nationwide supplementary immunization activities (SIAs) greatly reduced measles prevalence in Guangdong, a province southern China with the largest migrant population. However, during 2013-2014, Guangdong experienced resurgence of epidemic. This study was performed to examine association between infections migrants epidemic.The records 22 362 clinically laboratory-confirmed cases from years 2014 were extracted National Infectious Disease Monitoring Information...