A5101820815- Ocular Surface and Contact Lens
- Inflammatory mediators and NSAID effects
- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- Gastric Cancer Management and Outcomes
- Advanced Drug Delivery Systems
- S100 Proteins and Annexins
- Sphingolipid Metabolism and Signaling
- Advancements in Transdermal Drug Delivery
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Plant Molecular Biology Research
- HIV Research and Treatment
- Metastasis and carcinoma case studies
- Optical Network Technologies
- Synthesis and biological activity
- Drug Transport and Resistance Mechanisms
- Glaucoma and retinal disorders
- Corneal Surgery and Treatments
- Advanced Photonic Communication Systems
- Bone health and treatments
- Eicosanoids and Hypertension Pharmacology
- Inhalation and Respiratory Drug Delivery
- Pelvic floor disorders treatments
- Urinary Bladder and Prostate Research
- Cancer, Hypoxia, and Metabolism
Jingdezhen Ceramic Institute
2011-2025
Fujian Medical University
2017-2025
Second Affiliated Hospital of Fujian Medical University
2017-2025
China Medical University
2025
Shanghai East Hospital
2018-2024
Medicon (United States)
2011-2024
Sun Yat-sen University
2016-2024
Soochow University
2022-2024
First Affiliated Hospital of Soochow University
2022-2024
Zhuhai People's Hospital
2012-2024
Annexin A1 (ANXA1), a mediator of the anti-inflammatory action glucocorticoids, is important in cancer development and progression, whereas NF-kappaB regulates multiple cellular phenomena, some them associated with inflammation cancer. We showed that glucocorticoids chemopreventive modified nonsteroidal drugs, such as nitric oxide-donating aspirin (NO-ASA) phospho-aspirin, induced ANXA1 cultured human colon pancreatic cells. suppressed its transcriptional activity by preventing binding to...
Targeted therapy is highly challenging and urgently needed for patients diagnosed with triple negative breast cancer (TNBC). Here, a synergistic treatment platform plasmonic-magnetic hybrid nanoparticle (lipids, doxorubicin (DOX), gold nanorods, iron oxide nanocluster (LDGI))-loaded mesenchymal stem cells (MSCs) photoacoustic imaging, targeted photothermal therapy, chemotherapy TNBC developed. LDGI can be efficiently taken up into the good biocompatibility to maintain cellular functions. In...
Abstract In cells, mechanical forces play a key role in impacting cell behaviors, including adhesion, differentiation, migration, and death. Herein, 20 nm mitochondria‐targeted zinc‐doped iron oxide nanocube is designed as nanospinner to exert under rotating magnetic field (RMF) at 15 Hz 40 mT fight against cancer. The nanospinners can efficiently target the mitochondria of cancer cells. By means RMF, nanocubes assemble alignment with external produce localized force impair Both vitro vivo...
Background Digital network–based methods may enhance peer distribution of HIV self-testing (HIVST) kits, but interventions that can optimize this approach are needed. We aimed to assess whether monetary incentives and referral could improve a secondary program for HIVST among men who have sex with (MSM) in China. Methods findings Between October 21, 2019 September 14, 2020, 3-arm randomized controlled, single-blinded trial was conducted online 309 individuals (defined as index participants)...
Supercapacitors (SCs) are a novel type of energy storage device that exhibit features such as short charging time, long service life, excellent temperature characteristics, saving, and environmental protection. The capacitance SCs depends on the electrode materials. Currently, carbon-based materials, transition metal oxides/hydroxides, conductive polymers widely used However, low specific high cost poor cycling performance electrodes limit their applications. Copper-sulfur compounds...
New agents are needed to treat pancreatic cancer, one of the most lethal human malignancies. We synthesized phospho-valproic acid, a novel valproic acid derivative, (P-V; MDC-1112) and evaluated its efficacy in control cancer. P-V inhibited growth cancer xenografts mice by 60%–97%, 100% when combined with cimetidine. The dominant molecular target was STAT3. phosphorylation JAK2 Src, Hsp90-STAT3 association, suppressing activating STAT3, which turn reduced expression STAT3-dependent proteins...
Abstract Serine palmitoyltransferase (SPT), a pyridoxyl-5′-phosphate-dependent enzyme, catalyzes the first and rate-limiting step in sphingolipid biosynthesis. In humans yeast, orosomucoid proteins (ORMs) negatively regulate SPT thus play an important role maintaining levels. Despite importance of sphingoid intermediates as bioactive molecules, regulation biosynthesis through is not well understood plants. Here, we identified characterized Arabidopsis thaliana ORMs, ORM1 ORM2. Loss function...
Our exploration of multimodal nanoprobes aims to combine photoacoustic (PA) imaging, 19F magnetic resonance (MR), and fluorescence (FL) which offers complementary advantages such as high spatial resolution, unlimited penetration, sensitivity enable more refined images for accurate tumor diagnoses. In this research, perfluorocarbons (PFCs) indocyanine green (ICG) are encapsulated by poly(lactic-co-glycolic acid) (PLGA) intravital MR/FL/PA tri-modal imaging-guided photothermal therapy. Then,...
Brain tumor segmentation remains a challenge in medical image tasks. With the application of transformer various computer vision tasks, blocks show capability learning long-distance dependency global space, which is complementary to CNNs. In this paper, we proposed novel transformer-based generative adversarial network automatically segment brain tumors with multi-modalities MRI. Our architecture consists generator and discriminator, trained min-max game progress. The based on typical...
To understand the effects of low-frequency pulsed electromagnetic fields (PEMFs) on chronic bony pain, bone mineral density (BMD), strength and biochemical markers metabolism in patients osteoporosis.Using key words "pulsed fields" "osteoporosis", we searched PubMed for related studies published English from January 1996 to December 2007. We also China National Knowledge Infrastructure (CNKI) Chinese 2007.(1) all articles which referred magnetic osteoporosis either primary or secondary...
BACKGROUND AND PURPOSE The use of non‐steroidal anti‐inflammatory drugs (NSAIDs) in the treatment rheumatoid arthritis (RA) is limited by their toxicity. We evaluated efficacy and safety three novel modified NSAIDs, phospho‐aspirin, phospho‐ibuprofen phospho‐sulindac. EXPERIMENTAL APPROACH determined effects gastrointestinal phospho‐NSAIDs rat adjuvant model studied mechanism action cultured cells, Cytokines were measured with elisa activation nuclear factor‐κB (NF‐κB) immunohistochemistry....
The nonsteroidal anti-inflammatory drug (NSAID) sulindac and the ornithine decarboxylase (ODC) antagonist difluoromethylornithine (DFMO), individually together, are effective inhibitors of colon carcinogenesis. However, chronic use is associated with significant side effects. We evaluated chemopreventive efficacy phospho-sulindac (P-S, OXT-328), an apparently safe derivative sulindac, together DFMO, in HT-29 human cancer xenografts. Nude mice were divided into four groups as follows: group 1...
This study aimed to investigate the relationships among overactive bladder (OAB) symptom severity, bother, help-seeking behavior, and quality of life (QOL) in patients with type 2 diabetes.A total 127 diabetic patients, aged at least 18 years, from a hospital Shandong Province, China, were recruited for this study. Symptom assessed using Overactive Bladder Score (OABSS), Patient Perception Condition (PPBC), Questionnaire Short Form (OAB-q SF), respectively. Help-seeking behavior was by...
Sphingolipids, a class of bioactive lipids found in cell membranes, can modulate the biophysical properties membranes and play critical role signal transduction. Sphingolipids are involved autophagy humans yeast, but their plants is not well understood. In this study, we reported that AtACER, an alkaline ceramidase hydrolyses ceramide to long-chain base (LCB), functions process Arabidopsis. Our empirical data showed loss AtACER inhibited autophagy, its overexpression promoted under nutrient,...
Sphingolipids have key functions in plant membrane structure and signaling. Perturbations of sphingolipid metabolism often induce cell death salicylic acid (SA) accumulation; SA accumulation, turn, promotes further death. However, the underlying molecular mechanisms remain unclear. Here, we show that Arabidopsis thaliana lipase-like protein ENHANCED DISEASE SUSCEPTIBILITY 1 (EDS1) its partner PHYTOALEXIN DEFICIENT 4 (PAD4) participate associated The accelerated 5 (acd5) mutants accumulate...
Post-traumatic stress disorder (PTSD) is the most common psychiatric sequelae among novel coronavirus disease (COVID-19) patients. The aim of this study was to determine prevalence PTSD symptoms, PTSD-related factors, and its relationship with quality life at long-term follow-up in hospitalized COVID-19 survivors.
Differentiated thyroid cancer (DTC) often seriously impacts patients' lives. Radionuclide Iodine-131 (131I) is widely used in treating patients with DTC. However, most know little about radionuclide therapy, and the treatment needs to be performed a special isolation ward, which can cause anxiety depression.To explore depression status their influencing factors after 131I DTC.A questionnaire survey was conducted among postoperative DTC who received at our hospital from June 2020 December...
We assessed the relationship between oxidative stress, cytokinetic parameters, and tumor growth in response to novel phospho-nonsteroidal anti-inflammatory drugs (NSAIDs), agents with significant anticancer effects preclinical models. Compared controls, SW480 colon MCF-7 breast cancer cells, phospho-sulindac, phospho-aspirin, phospho-flurbiprofen, phospho-ibuprofen (P-I) increased levels of reactive oxygen nitrogen species (RONS) decreased GSH thioredoxin reductase activity, whereas...
Nonsteroidal anti-inflammatory drugs (NSAID) exhibit antineoplastic properties, but conventional NSAIDs do not fully meet safety and efficacy criteria for use as anticancer agents. In this study, we evaluated the chemotherapeutic of 5 novel phospho-NSAIDs, each which includes in addition to NSAID moiety a diethylphosphate linked through butane moiety. All compounds inhibited growth human breast, colon, pancreatic cancer cell lines with micromolar potency. vivo investigations confirmed...