A5085702699- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Micro and Nano Robotics
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Characterization and Applications of Magnetic Nanoparticles
- Microfluidic and Bio-sensing Technologies
- Photoacoustic and Ultrasonic Imaging
- Cellular Mechanics and Interactions
- Electron Spin Resonance Studies
- Extracellular vesicles in disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Microtubule and mitosis dynamics
- Advanced MRI Techniques and Applications
- Advanced Nanomaterials in Catalysis
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- MicroRNA in disease regulation
- Graphene and Nanomaterials Applications
- Physics of Superconductivity and Magnetism
- Lanthanide and Transition Metal Complexes
- Signaling Pathways in Disease
- Regional Economic and Spatial Analysis
- Heme Oxygenase-1 and Carbon Monoxide
- MRI in cancer diagnosis
Tongji University
2016-2025
Dalian Medical University
2024-2025
Second Affiliated Hospital of Dalian Medical University
2024-2025
Second Affiliated Hospital of Nanchang University
2025
Nanchang University
2025
Institute of Laboratory Animal Science
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Fujian Medical University
2025
Union Hospital
2025
Zhujiang Hospital
2025
Abstract Purpose: Glioblastoma (GBM) is the most common form of malignant glioma in adults. Although protected by both blood–brain and blood–tumor barriers, GBMs are actively infiltrated T cells. Previous work has shown that IDO, CTLA-4, PD-L1 dominant molecular participants suppression GBM immunity. This includes IDO-mediated regulatory T-cell (Treg; CD4+CD25+FoxP3+) accumulation, interaction T-cell–expressed, with dendritic cell-expressed, CD80, as well tumor- and/or macrophage-expressed,...
The blood-brain barrier (BBB) remains a formidable obstacle in medicine, preventing efficient penetration of chemotherapeutic and diagnostic agents to malignant gliomas. Here, transactivator transcription (TAT) peptide-modified gold nanoparticle platform (TAT-Au NP) with 5 nm core size is demonstrated be capable crossing the BBB efficiently delivering cargoes such as anticancer drug doxorubicin (Dox) Gd(3+) contrast brain tumor tissues. Treatment mice bearing intracranial glioma xenografts...
Microrobots driven by multiple propelling forces hold great potential for noninvasively targeted delivery in the physiologic environment. However, remotely collective perception and precise a low Reynold's number bioenvironment remain major challenges of microrobots to achieve desired therapeutic effects vivo. Here, we reported biohybrid microrobot that integrated with magnetic, thermal, hypoxia sensitivities an internal fluorescent protein as dual reporter thermal positioning signals cancer...
Glioblastoma-targeted drug delivery systems facilitate efficient of chemotherapeutic agents to malignant gliomas, while minimizing systemic toxicity and side effects. Taking advantage the fibrin deposition that is characteristic tumors, we constructed spherical, Cy7-labeled, targeting micelles glioblastoma through addition fibrin-binding pentapeptide, cysteine-arginine-glutamic acid-lysine-alanine, or CREKA. Conjugation CREKA peptide Cy7-micelles increased average particle size zeta...
Abstract New‐era soft microrobots for biomedical applications need to mimic the essential structures and collective functions of creatures from nature. Biocompatible interfaces, intelligent functionalities, precise locomotion control in a manner are key parameters design complex bio‐environment. In this work, biomimetic magnetic microrobot (BMM) inspired by magnetotactic bacteria (MTB) with speedy motion response accurate positioning is developed targeted thrombolysis. Similar magnetosome...
EGF-modified Au NP–Pc 4 conjugates showed 10-fold improved selectivity to the brain tumor compared untargeted conjugates. The hydrophobic photodynamic therapy drug Pc can be delivered efficiently into glioma tumors by EGF peptide-targeted NPs. Compared conjugates, EGF–Au tumor. This delivery system holds promise for future of a wider range therapeutic drugs treatment hard-to-reach cancers. Detailed facts importance specialist readers are published as "Supporting Information". Such documents...
As therapies continue to increase the lifespan of patients with breast cancer, incidence brain metastases has steadily increased, affecting a significant number metastatic disease. However, major barrier toward treating these lesions is inability therapeutics penetrate into central nervous system and accumulate within intracranial tumor sites. In this study, we designed cell-penetrating gold nanoparticle platform drug delivery cancer cells. TAT peptide-modified nanoparticles carrying...
BackgroundOncolytic adenoviral virotherapy (OV) is a highly promising approach for the treatment of glioblastoma multiforme (GBM). In practice, however, limited by poor viral distribution and spread throughout tumor mass.
Magnetic nanoparticles (MNPs) functionalized with targeting moieties can recognize specific cell components and induce mechanical actuation under magnetic field.Their size is adequate for reaching tumors cancer cells.However, due to the nanometric size, force generated by MNPs smaller than required largely disrupting key of cells.Here, we show assembly process inside cells, form elongated aggregates produce elevated forces.We synthesized iron oxide doped zinc, obtain high magnetization,...
Targeted therapy is highly challenging and urgently needed for patients diagnosed with triple negative breast cancer (TNBC). Here, a synergistic treatment platform plasmonic-magnetic hybrid nanoparticle (lipids, doxorubicin (DOX), gold nanorods, iron oxide nanocluster (LDGI))-loaded mesenchymal stem cells (MSCs) photoacoustic imaging, targeted photothermal therapy, chemotherapy TNBC developed. LDGI can be efficiently taken up into the good biocompatibility to maintain cellular functions. In...
Osteoarthritis (OA) is a degenerative disease that involves excess reactive oxygen species (ROS) and osteochondral defects. Although multiple approaches have been developed for regeneration, how to balance the biochemical physical microenvironment in OA remains big challenge. In this study, bioceramic scaffold by 3D printed akermanite (AKT) integrated with hair-derived antioxidative nanoparticles (HNPs)/microparticles (HMPs) ROS scavenging regeneration has developed. The prepared bioscaffold...
A 3-step glioblastoma-tropic delivery and therapy method using nanoparticle programmed self-destructive neural stem cells (NSCs) is demonstrated in vivo: 1) FDA-approved NSCs for clinical trials are loaded with pH-sensitive MSN-Dox; 2) the conjugates provide a delayed drug-releasing mechanism allow NSC migration towards distant tumor site; 3) eventually undergo cell death release impregnated MSN-Dox, which subsequently induces toxicity surrounding glioma cells.
Pathological cardiac fibrosis and hypertrophy, the common features of left ventricular remodeling, often progress to heart failure. Forkhead box transcription factor P1 (Foxp1) in endothelial cells (ECs) has been shown play an important role development. However, effect EC-Foxp1 on pathological remodeling not well clarified. This study aims determine underlying mechanisms.Foxp1 EC-specific loss-of-function gain-of-function mice were generated, angiotensin II infusion or a transverse aortic...
Abstract Reactive oxygen species (ROS), a group of derived radicals and derivatives, can induce cancer cell death via elevated oxidative stress. A spatiotemporal approach with safe deep‐tissue penetration capabilities to elevate the intracellular ROS level is highly desirable for precise treatment. Here, mechanical‐thermal induction therapy (MTIT) strategy developed programmable increase levels in cells assembly magnetic nanocubes integrated alternating fields. The magneto‐based mechanical...