A5107859114- Mosquito-borne diseases and control
- Neuroinflammation and Neurodegeneration Mechanisms
- Malaria Research and Control
- vaccines and immunoinformatics approaches
- Neurological Disease Mechanisms and Treatments
- Invertebrate Immune Response Mechanisms
- Insect Resistance and Genetics
- Stroke Rehabilitation and Recovery
- Nerve injury and regeneration
- Tryptophan and brain disorders
- Plant Pathogens and Fungal Diseases
- HIV Research and Treatment
- Antenna Design and Analysis
- Fermentation and Sensory Analysis
- Catalytic Processes in Materials Science
- Microbial infections and disease research
- Viral Infections and Vectors
- Spinal Fractures and Fixation Techniques
- Insect symbiosis and bacterial influences
- Biochemical effects in animals
- Gut microbiota and health
- Spinal Dysraphism and Malformations
- Plant Disease Resistance and Genetics
- Alzheimer's disease research and treatments
- Dark Matter and Cosmic Phenomena
First Affiliated Hospital of Hebei Medical University
2025
Southwest Jiaotong University
2024-2025
Sichuan University
2004-2025
West China Hospital of Sichuan University
2019-2025
Second Affiliated Hospital of Nanjing Medical University
2023-2025
Guizhou University
2024-2025
Chengdu University of Traditional Chinese Medicine
2024-2025
Guilin University of Electronic Technology
2024
Zhengzhou University
2024
Chinese Academy of Sciences
2013-2024
Significance A highly effective malaria vaccine capable of long-term protection against genetically diverse strains is urgently needed. Here, we demonstrate that a three-dose regimen live attenuated whole-parasite conferred durable sterile through 33 weeks in ∼50% subjects controlled human infection strain heterologous to the strain. Prior studies by others and us have shown T cells are critical mediating after live-attenuated vaccination. provide evidence this Plasmodium falciparum...
BACKGROUND: A radiation-attenuated Plasmodium falciparum (Pf) sporozoite (SPZ) malaria vaccine, PfSPZ Vaccine, protected 6 of subjects (100%) against homologous Pf (same strain as in the vaccine) controlled human infection (CHMI) 3 weeks after 5 doses administered intravenously. The next step was to assess protective efficacy heterologous (different from vaccine), fewer doses, and at 24 weeks. METHODS: trial assessed tolerability, safety, immunogenicity, direct venous inoculation (DVI) or...
Abstract Background Spinal cord injury (SCI) favors a persistent pro-inflammatory macrophages/microglia-mediated response with only transient appearance of anti-inflammatory phenotype immune cells. However, the mechanisms controlling this special sterile inflammation after SCI are still not fully elucidated. It is known that damage-associated molecular patterns (DAMPs) released from necrotic cells can trigger severe inflammation. High mobility group box 1(HMGB1), ubiquitously expressed DNA...
The PandaX-4T liquid xenon detector at the China Jinping Underground Laboratory is used to measure solar <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" display="inline"><a:mrow><a:mmultiscripts><a:mrow><a:mi mathvariant="normal">B</a:mi></a:mrow><a:mprescripts/><a:none/><a:mrow><a:mn>8</a:mn></a:mrow></a:mmultiscripts></a:mrow></a:math> neutrino flux by detecting neutrinos through coherent scattering with nuclei. Data samples requiring coincidence of scintillation and ionization...
PandaX-4T experiment is a deep-underground dark matter direct search that employs dual-phase time projection chamber with sensitive volume containing 3.7 tonne of liquid xenon. The detector capable simultaneously collecting the primary scintillation and ionization signals, utilizing their ratio to discriminate signals from background sources such as gamma rays beta particles. signal response model plays crucial role in interpreting data obtained by PandaX-4T. It describes conversion...
Stroke is one of the leading causes morbidity and mortality worldwide. Inflammation, oxidative stress, apoptosis, excitotoxicity contribute to neuronal death during ischemic stroke; however, mechanisms underlying these complicated pathophysiological processes remain be fully elucidated. Here, we found that expression tumor necrosis factor receptor-associated 6 (TRAF6) was markedly increased after cerebral ischemia/reperfusion (I/R) in mice. TRAF6 ablation male mice decreased infarct volume...
Plasmodium falciparum (Pf) whole-organism sporozoite vaccines have been shown to provide significant protection against controlled human malaria infection (CHMI) in clinical trials. Initial CHMI studies showed significantly higher durable homologous than heterologous strains, suggesting the presence of strain-specific vaccine-induced protection. However, interpretation these results and understanding their relevance vaccine efficacy hampered by lack knowledge on genetic differences between...
Virulence of the most deadly malaria parasite Plasmodium falciparum is linked to variant surface antigen PfEMP1, which encoded by about 60 var genes per genome. Although expression particular variants has been associated with different clinical outcomes, little known gene at onset infection. By analyzing controlled human infections via quantitative real-time PCR, we show that populations from 18 volunteers expressed virtually identical transcript patterns were dominated subtelomeric group B...
Ischemic stroke is characterized by permanent or transient obstruction of blood flow, which initiates a cascading pathological process, starting from acute ATP loss and ionic imbalance to subsequent membrane depolarization, glutamate excitotoxicity, calcium overload. These initial events are followed neuroinflammation oxidative stress, eventually causing neuronal neurosis apoptosis. Complicated interplays exist between these steps happening across various stages, not only represent the...
Abstract Generating effective and durable T cell immunity is a critical prerequisite for vaccination against dengue virus (DENV) other viral diseases. However, understanding the molecular mechanisms of vaccine-elicited remains knowledge gap in vaccinology. In this study, we utilize single-cell RNA sequencing (scRNAseq) longitudinal TCR clonotype analysis to identify unique transcriptional signature present acutely activated clonally-expanded cells that become committed memory repertoire....
: Reactive oxygen species (ROS) act as modulators triggering cellular dysfunctions and organ damage including liver fibrosis in which hepatic stellate cell (HSC) activation plays a key role. Previous studies suggest that microRNA-144 (miR-144) acts pro-oxidant molecule; however, whether how miR-144 affects HSC remain unknown.
Abstract Posterior fossa tumors are the most common childhood intracranial tumors, and radiotherapy is one of effective treatments. However, irradiation induces long-term adverse effects that can have significant negative impacts on patient’s quality life. The purpose this study was to characterize irradiation-induced cellular molecular changes in cerebellum. We found cell death occurred mainly external germinal layer (EGL) juvenile rat number proliferating cells EGL decreased, 82.9% them...
Background This study explored the epidemiological trends in pelvic fracture (PF) China from 1992 to 2021, analyze their relationships with age–period–cohort (APC) factors, and predict of PF 2022 2046. Methods Incidence years lived disabilities (YLDs) among sexes 2021 were obtained through Global Burden Disease (GBD) database. Trends incidence YLDs described, a joinpoint regression model was used. The APC used explore effects age, period, cohort on YLDs. Nordpred forecasted Results In there...
Microglia/macrophages (MG/MΦ) are found in the subretinal space both mice and humans. Our goal was to study spatial temporal distribution, phenotype, gene expression of MG/MΦ with normal retinas compare them known retinal pathology.We studied C57BL/6 (C57BL/6N), or without (C57BL/6J) rd8 mutation Crb1 (which, presence yet unidentified permissive/modifying genes, leads a degeneration), documented their fundus appearance change aging. Immunostaining pigment epithelium (RPE) flat mounts done...
The ability to undertake controlled human malaria infection (CHMI) studies for preliminary evaluation of vaccine candidates and anti-malaria drug efficacy has been limited by the need access sporozoite infected mosquitoes, aseptic, purified, cryopreserved sporozoites or blood-stage parasites derived ex vivo from individuals. Three different strategies are described manufacture clinical grade cultured cell banks suitable use in CHMI studies. Good Manufacturing Practices (GMP)-grade Plasmodium...
Abstract Radiotherapy is an effective tool in the treatment of malignant brain tumors. However, damage to stem and progenitor cells constitutes a major problem associated with long-term side effects. Autophagy has been shown be involved cell death, purpose this study was evaluate effect autophagy inhibition on neural death juvenile brain. Ten-day-old selective Atg7 knockout (KO) mice wild-type (WT) littermates were subjected single 6Gy dose whole-brain irradiation. Cell proliferation as well...