Peter F. Billingsley
A5073651555- Mosquito-borne diseases and control
- Malaria Research and Control
- Insect Resistance and Genetics
- Invertebrate Immune Response Mechanisms
- Insect symbiosis and bacterial influences
- Parasites and Host Interactions
- Vector-borne infectious diseases
- Travel-related health issues
- Trypanosoma species research and implications
- Viral Infectious Diseases and Gene Expression in Insects
- Insect Pest Control Strategies
- Complement system in diseases
- Insect-Plant Interactions and Control
- Neurobiology and Insect Physiology Research
- HIV Research and Treatment
- Research on Leishmaniasis Studies
- Helminth infection and control
- Hepatitis B Virus Studies
- Parasite Biology and Host Interactions
- vaccines and immunoinformatics approaches
- Insect Utilization and Effects
- Viral Infections and Vectors
- Vector-Borne Animal Diseases
- Insect behavior and control techniques
- Study of Mite Species
Sanaria
2016-2025
Narrative (Sweden)
2025
University of Maryland, Baltimore
2010-2015
Protein Potential (United States)
2010-2015
Emmes (United States)
2015
Centers for Disease Control and Prevention
2015
Howard Hughes Medical Institute
2015
University of Aberdeen
1999-2013
Imperial College London
1988-2010
Radboud University Nijmegen
2010
Consistent, high-level, vaccine-induced protection against human malaria has only been achieved by inoculation of Plasmodium falciparum (Pf) sporozoites (SPZ) mosquito bites. We report that the PfSPZ Vaccine--composed attenuated, aseptic, purified, cryopreserved PfSPZ--was safe and well tolerated when administered four to six times intravenously (IV) 40 adults. Zero subjects receiving five doses three nine 1.35 × 10(5) Vaccine nonvaccinated controls developed after controlled infection (P =...
Our goal is to develop a vaccine that sustainably prevents Plasmodium falciparum (Pf) malaria in ≥80% of recipients. Pf sporozoites (PfSPZ) administered by mosquito bites are the only immunogens shown induce such protection humans. Such thought be mediated CD8(+) T cells liver secrete interferon-γ (IFN-γ). We report purified irradiated PfSPZ 80 volunteers needle inoculation skin was safe, but suboptimally immunogenic and protective. Animal studies demonstrated intravenous immunization...
Significance A highly effective malaria vaccine capable of long-term protection against genetically diverse strains is urgently needed. Here, we demonstrate that a three-dose regimen live attenuated whole-parasite conferred durable sterile through 33 weeks in ∼50% subjects controlled human infection strain heterologous to the strain. Prior studies by others and us have shown T cells are critical mediating after live-attenuated vaccination. provide evidence this Plasmodium falciparum...
BACKGROUND: A radiation-attenuated Plasmodium falciparum (Pf) sporozoite (SPZ) malaria vaccine, PfSPZ Vaccine, protected 6 of subjects (100%) against homologous Pf (same strain as in the vaccine) controlled human infection (CHMI) 3 weeks after 5 doses administered intravenously. The next step was to assess protective efficacy heterologous (different from vaccine), fewer doses, and at 24 weeks. METHODS: trial assessed tolerability, safety, immunogenicity, direct venous inoculation (DVI) or...
At a recent workshop, experts discussed the benefits, risks, and research priorities associated with using genetically manipulated insects in control of vector-borne diseases.
With a growing world population and increasingly demanding consumers, the production of sufficient protein from livestock, poultry, fish represents serious challenge for future. Approximately 1,900 insect species are eaten worldwide, mainly in ...Read More
Controlled human malaria infection with sporozoites is a standardized and powerful tool for evaluation of vaccine drug efficacy but so far only applied by exposure to bites Plasmodium falciparum (Pf)-infected mosquitoes. We assessed in an open label Phase 1 trial, after intradermal injection respectively 2,500, 10,000, or 25,000 aseptic, purified, vialed, cryopreserved Pf (PfSPZ) three groups ( N = 6/group) healthy Dutch volunteers. Infection was safe parasitemia developed 15 18 volunteers...
We are using controlled human malaria infection (CHMI) by direct venous inoculation (DVI) of cryopreserved, infectious Plasmodium falciparum (Pf) sporozoites (SPZ) (PfSPZ Challenge) to try reduce time and costs developing PfSPZ Vaccine prevent in Africa. Immunization with five doses at 0, 4, 8, 12, 20 weeks 2.7 × 105 gave 65% vaccine efficacy (VE) 24 against mosquito bite CHMI U.S. adults 52% (time event) or 29% (proportional) VE over naturally transmitted Pf Malian adults. assessed the...
Controlled human malaria infection (CHMI) by mosquito bite has been used to assess anti-malaria interventions in > 1,500 volunteers since development of methods for infecting mosquitoes feeding on Plasmodium falciparum (Pf) gametocyte cultures. Such CHMIs have never Africa. Aseptic, purified, cryopreserved Pf sporozoites, PfSPZ Challenge, were infect Dutch intradermal injection. We conducted a double-blind, placebo-controlled trial safety and infectivity Challenge adult male Tanzanians....
Controlled human malaria infection (CHMI) accelerates development of anti-malarial interventions. So far, CHMI is done by exposure volunteers to bites five mosquitoes carrying Plasmodium falciparum sporozoites (PfSPZ), a technique available in only few centres worldwide. Mosquito-mediated logistically complex, exact PfSPZ dosage impossible and live mosquito-based interventions are not suitable for further clinical development. An open-labelled, randomized, dose-finding study 18–45 year old,...
Mosquito fitness is determined largely by body size and nutritional reserves. Plasmodium infections in the mosquito resultant transmission of malaria parasites might be compromised vector's status. We studied effects stress parasite on Anopheles mosquitoes.Larvae gambiae sensu stricto An. stephensi were reared at constant density but with nutritionally low high diets. Fitness adult mosquitoes resulting from each dietary class was assessed measuring lipid, protein glycogen content. The first...
Controlled human malaria infection (CHMI) studies are a vital tool to accelerate vaccine and drug development. As CHMI trials performed in controlled environment, they allow unprecedented, detailed evaluation of parasite growth dynamics (PGD) immunological responses. However, have not been routinely malaria-endemic countries or used investigate mechanisms naturally-acquired immunity (NAI) Plasmodium falciparum.We conducted an open-label, randomized pilot-study using aseptic, cryopreserved P....
In the context of stalling progress against malaria, resistance mosquitoes to insecticides, and residual transmission, mass drug administration (MDA) ivermectin, an endectocide used for neglected tropical diseases (NTDs), has emerged as a promising complementary vector control method. Ivermectin reduces life span
Background Controlled human malaria infection (CHMI) studies have become a routine tool to evaluate efficacy of candidate anti-malarial drugs and vaccines. To date, CHMI trials mostly been conducted using the bite infected mosquitoes, restricting number trial sites that can perform studies. Aseptic, cryopreserved P. falciparum sporozoites (PfSPZ Challenge) provide potentially more accurate, reproducible practical alternative, allowing known be administered simply by injection. Methodology We...