A5035123061- Child Nutrition and Water Access
- Folate and B Vitamins Research
- Iron Metabolism and Disorders
- Global Maternal and Child Health
- Hemoglobinopathies and Related Disorders
- Parasites and Host Interactions
- Infant Nutrition and Health
- Parasite Biology and Host Interactions
- SARS-CoV-2 and COVID-19 Research
- Malaria Research and Control
- Respiratory and Cough-Related Research
- Pregnancy and preeclampsia studies
- Tuberculosis Research and Epidemiology
- COVID-19 epidemiological studies
- Voice and Speech Disorders
- HIV-related health complications and treatments
- SARS-CoV-2 detection and testing
- Mobile Health and mHealth Applications
- HIV/AIDS Impact and Responses
- Music and Audio Processing
- Gestational Diabetes Research and Management
- Pharmaceutical studies and practices
- Pregnancy and Medication Impact
- Ethics in Clinical Research
- Invertebrate Immune Response Mechanisms
Ifakara Health Institute
2014-2025
Sensitive diagnostic tools are crucial for an accurate assessment of helminth infections in low-endemicity areas. We examined stool samples from Tanzanian individuals and compared the accuracy a real-time polymerase chain reaction (PCR) with FLOTAC technique Kato–Katz method hookworm Baermann Strongyloides stercoralis detection. Only had higher sensitivity than diagnosis; sensitivities PCR were equal. very low S. The cycle threshold values negatively correlated logarithm egg larvae counts....
Controlled human malaria infection (CHMI) by mosquito bite has been used to assess anti-malaria interventions in > 1,500 volunteers since development of methods for infecting mosquitoes feeding on Plasmodium falciparum (Pf) gametocyte cultures. Such CHMIs have never Africa. Aseptic, purified, cryopreserved Pf sporozoites, PfSPZ Challenge, were infect Dutch intradermal injection. We conducted a double-blind, placebo-controlled trial safety and infectivity Challenge adult male Tanzanians....
Mycobacterium tuberculosis and human immunodeficiency virus (HIV) infections are coendemic in several regions of the world, M. /HIV-coinfected individuals more susceptible to progression disease. We therefore hypothesized that HIV infection would potentially impair -specific protective immunity suffering from latent (LTBI) or active pulmonary (PTB). In this study, we demonstrated have fewer circulating CD4 T cells those remained were functionally impaired both LTBI PTB settings. addition,...
BackgroundIron deficiency anaemia is of major concern in low-income settings, especially for women childbearing age. Oral iron substitution efficacy limited by poor compliance and depletion severity. We aimed to assess the safety intravenous ferric carboxymaltose versus oral following childbirth with Tanzania.MethodsThis parallel-group, open-label, randomised controlled phase 3 trial was done at Bagamoyo District Hospital Mwananyamala Hospital, Tanzania. Eligible participants were close...
ABSTRACT Cough is a common and commonly ignored symptom of lung disease. often perceived as difficult to quantify, frequently self-limiting, non-specific. However, cough has central role in the clinical detection many diseases including tuberculosis (TB), which remains leading infectious disease killer worldwide. TB screening currently relies on self-reported fails meet World Health Organization (WHO) accuracy targets for triage test. Artificial intelligence (AI) models based sound have been...
Abstract Broadly neutralizing antibodies (bNAbs) are promising candidates for the treatment and prevention of HIV-1 infections. Despite their critical importance, automatic detection bNAbs from immune repertoires is still lacking. Here, we develop a straightforward computational method Rapid Automatic Identification (RAIN) based on machine learning methods. In contrast to other approaches, which use one-hot encoding amino acid sequences or structural alignment prediction, RAIN uses...
Background Plasmodium and soil transmitted helminth infections (STH) are a major public health problem, particularly among children. There conflicting findings on potential association between these two parasites. This study investigated the co-infections children aged 2 months to 9 years living in Bagamoyo district, coastal region of Tanzania. Methods A community-based cross-sectional survey was conducted 1033 Stool, urine blood samples were examined using broad set quality controlled...
A critical impediment to efficient outbreak response is the availability of timely and complete data on cases their linkage care. To inform solutions this issue, study investigated utility self-testers reporting coronavirus disease 2019 results using a mobile health platform. Our has demonstrated that platform feasible; it achieved 74.5% rate, indicating strong likelihood entry into unstructured supplementary service Support from community workers (CHWs) healthcare professionals,...
Sub-Saharan Africa faces a disproportionate burden of HIV/AIDS, and Tanzania, reflecting this trend, challenges with only 60.6% individuals aged 15–64 aware their HIV status. Nevertheless, according to the present state affairs, mean coverage rate previous testing in Tanzania (66.5%) is still behind UNAIDS target. The 2030 target urges 95% awareness among those infected, sustained ARV therapy, viral suppression. To address this, amended its AIDS Act, permitting voluntary self-testing....
There is a paucity of data pertaining to the epidemiology and public health impact Enterobius vermicularis Strongyloides stercoralis infections. We aimed determine extent enterobiasis, strongyloidiasis, other helminth infections their association with asymptomatic Plasmodium parasitaemia, anaemia, nutritional status, blood cell counts in infants, preschool-aged (PSAC), school-aged children (SAC) from rural coastal Tanzania. A total 1,033 were included cross-sectional study implemented...
The effect of maternal multivitamin supplementation on breast milk vitamin B12 concentrations has not been examined in Tanzania, where the prevalence plasma insufficiency is 25.6%. Multivitamins (containing 50 µg B12) or placebo were provided during pregnancy and postpartum period. Breast samples collected at around six weeks from 491 participants a trial multivitamins (NCT00197548). Linear logistic regression models used to examine supplements concentration its associations with other...
Background Parasitic infectious agents rarely occur in isolation. Epidemiological evidence is mostly lacking, and little known on how the two common parasites Plasmodium soil transmitted helminths (STH) interact. There are contradictory findings different studies. Synergism, antagonism neutral effect have been documented between STH. This study investigated impact of STH clinical malaria presentation treatment outcome. Methods A matched case control with a semi longitudinal follow up...
Background: Though Maytenus senegalensis is one of the medicinal plants widely used in traditional medicine to treat infectious and inflammatory diseases Africa, there a lack safety data regarding its use. Therefore, study aimed asselss tolerability antimalarial herbal remedy M. senegalensis. Material Methods: The design was an open-label, single-arm, dose-escalation. Twelve eligible male healthy Tanzanians aged 18 45 years were enrolled four dose groups. Volunteers’...
Although studies on COVID-19 vaccine hesitancy are being undertaken widely worldwide, there is limited evidence in Tanzania. This study aims to assess the sociodemographic factors associated with and reasons given by unvaccinated participants. We conducted a mixed-method cross-sectional two components-health facilities communities-between March September 2022. A structured questionnaire in-depth interviews were used collect quantitative qualitative data, respectively. total of 1,508...
Abstract Objective A recent trial of vitamin B12 supplementation among Indian children 6–30 months found no effect on the incidence diarrhea and respiratory infections. These results differ with studies in adults that showed improvement immune response following treatment B12. We sought to determine how adequacy concentrations breast milk could act as modulator protect against infections up 18 urban Tanzania. Results prospective cohort study was undertaken association concentration acute...
Background: Despite several interventions, the prevalence of anemia and related complications remains high among infants in Tanzania. Objective: We sought to determine predictors iron-deficiency (IDA) HIV-negative women Dar es Salaam, Methods: Cross-sectional analysis 2826 mother–infant pairs who participated a trial vitamins perinatal outcomes Hemoglobin mean corpuscular volume were used at 6 12 months. Multiple logistic regression was maternal infant risk factors for during infancy....
Abstract Importance Open-access data challenges have the potential to accelerate innovation in artificial-intelligence (AI)-based tools for global health. A specimen-free rapid triage method TB is a health priority. Objective To develop and validate cough sound-based AI algorithms tuberculosis (TB) through Cough Diagnostic Algorithm Tuberculosis (CODA TB) DREAM challenge. Design In this diagnostic study, participating teams were provided cough-sound clinical demographic data. They asked...
Abstract A pilot implementation of the rapid diagnostic test program was performed to collect evidence feasibility, acceptability, and uptake COVID-19 AgRDT in Tanzania. We conducted a prospective cross-sectional study community provide quantitative details antigen (AgRDT) This undertaken between March 2022 September 2022. The implemented by distributing offering kits people suspected having Dar es Salaam through health workers. total 1039 participants consented participate survey. All...
<ns3:p>Background Vitamin B12 is an essential cofactor for two enzymes that have critical functions in pregnancy, both maternal health and fetal development. However, the optimal supplemental dosage its correlation with vitamin status during pregnancy remain inadequately understood due to limited data. Methods This a single-blinded, stratified, dose-ranging trial of supplementation will be conducted at Ifakara Health Institute Bagamoyo Clinical Trial Unit Bagamoyo, Tanzania. We enroll 40...
Abstract Cough is a common and commonly ignored symptom of lung disease. often perceived as difficult to quantify, frequently self-limiting, non-specific. However, cough has central role in the clinical detection many diseases including tuberculosis (TB), which remains leading infectious disease killer worldwide. TB screening currently relies on self-reported fails meet World Health Organization (WHO) accuracy targets for triage test. Artificial intelligence (AI) models based sound have been...
The rapid diagnosis of coronavirus disease 2019 (COVID-19) is critical for comprehensive public health response strategies, and self-testing with antigen diagnostic tests (Ag-RDTs) presents opportunities to test in hard-to-reach communities. Therefore, we evaluated the acceptability, feasibility, uptake Ag-RDT at community level Tanzania. From June October 2022, symptomatic individuals or those recent contact a known suspected COVID-19 patient were offered assisted testing within mining...