A5091300590- Mosquito-borne diseases and control
- Malaria Research and Control
- Vaccine Coverage and Hesitancy
- Global Maternal and Child Health
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Outbreaks Research
- Sex work and related issues
- COVID-19 epidemiological studies
- SARS-CoV-2 detection and testing
- Intimate Partner and Family Violence
- Mobile Health and mHealth Applications
- Insect Pest Control Strategies
- Immune responses and vaccinations
- HIV/AIDS Research and Interventions
- Homelessness and Social Issues
- Pharmacological Effects and Toxicity Studies
- Fecal contamination and water quality
- Biosensors and Analytical Detection
- Hepatitis B Virus Studies
- Epilepsy research and treatment
- COVID-19 diagnosis using AI
- Antibiotic Use and Resistance
- Adolescent Sexual and Reproductive Health
- Pharmaceutical studies and practices
- Insect Resistance and Genetics
Ifakara Health Institute
2020-2025
Muhimbili University of Health and Allied Sciences
2023
SummaryBackgroundIntimate partner violence (IPV) is a significant public health issue, closely tied to social and neighborhood environments. The impoverished, overcrowded, stressful conditions in urban slums may heighten IPV risk, yet evidence remains limited. This study aims assess the prevalence, disparities, trends of across low- middle-income countries (LMICs).MethodsThis cross-sectional used nationally representative Demographic Health Surveys data from 2006 2023, focusing on with...
Abstract Background Strengthening malaria control activities in Tanzania has dramatically declined human infections. However, there is an increasing epidemiological shift the burden on school-age children. The underlying causes for such remain unknown this context. This study explored and behaviours that could increase vulnerability of children to transmission risk provide insight into protection gap with existing interventions opportunities supplementary interventions. Methods...
Abstract Background In 2015, a China-UK-Tanzania tripartite pilot project was implemented in southeastern Tanzania to explore new model for reducing malaria burden and possibly scaling-out the approach into other malaria-endemic countries. The 1,7-malaria Reactive Community-based Testing Response (1,7-mRCTR) which is locally-tailored reporting febrile cases endemic villages developed stop transmission Plasmodium life-cycle. utilizes existing health facility data locally trained community...
ABSTRACT Piperaquine tetraphosphate (PQP), a long‐acting antimalarial, is being considered in combination for chemoprevention. Dihydroartemisinin‐piperaquine tablets (hard and dispersible) approved the treatment of acute uncomplicated malaria should be administered fasted state, as PQP bioavailability increases with food. A new taste‐masked dispersible granules formulation aims to minimize impact food on drug exposure. This randomized, open label, parallel group, Phase I pilot study was...
A critical impediment to efficient outbreak response is the availability of timely and complete data on cases their linkage care. To inform solutions this issue, study investigated utility self-testers reporting coronavirus disease 2019 results using a mobile health platform. Our has demonstrated that platform feasible; it achieved 74.5% rate, indicating strong likelihood entry into unstructured supplementary service Support from community workers (CHWs) healthcare professionals,...
Sub-Saharan Africa faces a disproportionate burden of HIV/AIDS, and Tanzania, reflecting this trend, challenges with only 60.6% individuals aged 15–64 aware their HIV status. Nevertheless, according to the present state affairs, mean coverage rate previous testing in Tanzania (66.5%) is still behind UNAIDS target. The 2030 target urges 95% awareness among those infected, sustained ARV therapy, viral suppression. To address this, amended its AIDS Act, permitting voluntary self-testing....
Malaria rapid diagnostic tests (mRDTs) have played an important role in the early detection of clinical malaria endemic area. While several mRDTs are currently on market, availability with high sensitivity and specificity will merit fight against malaria. We evaluated field performance a novel One Step (P.f/P.v) Tri-line (P.f) test kits Pwani, Tanzania.In cross-sectional study conducted Bagamoyo Kibiti districts Tanzania, symptomatic patients were tested using SD BIOLINE, kits, microscope,...
Abstract Background Progress in malaria control has stalled recent years and innovative surveillance response approaches are needed to accelerate elimination efforts endemic areas of Africa. Building on a previous China-UK-Tanzania pilot study control, this aimed assess the impact 1,7-malaria Reactive Community-Based Testing Response (1,7-mRCTR) approach implemented over two three districts Tanzania. Methods The 1,7-mRCTR provides community-based testing via rapid diagnostic tests treatment...
Introduction Insecticide-treated nets (ITNs), specifically long-lasting insecticidal (LLINs), are the most commonly used, scalable, and cost-effective tools for controlling malaria transmission in sub-Saharan Africa. However, multiple alternative uses of retired LLINs have been associated with poor disposal practices. The World Health Organization (WHO) has provided guidelines recommendations proper management worn-out LLINs. This study assessed existing practices old Methods An explanatory...
Immunization has saved millions of lives globally from vaccine-preventable diseases. Childhood immunization is an effective public health strategy for decreasing morbidity and mortality among children in developing countries. Tanzania one the highest rates coverage routine child sub-Saharan African However, obstacles to universal still exist, particularly rural areas country. Assessing essential inform vaccine policies program implementation. This study aimed assess status factors associated...
Abstract Background: Strengthening malaria control activities in Tanzania has dramatically declined human infections. However, the burden is now higher among school-age children, but with inconsistency of evidence on risk factors and underlying causes for such an epidemiological shift. This study explored behaviors that increase vulnerability children to transmission risk. Methods: Twenty-four focus group discussions (FGDs) were conducted three districts Rufiji, Kibiti Kilwa south-eastern...
Although studies on COVID-19 vaccine hesitancy are being undertaken widely worldwide, there is limited evidence in Tanzania. This study aims to assess the sociodemographic factors associated with and reasons given by unvaccinated participants. We conducted a mixed-method cross-sectional two components-health facilities communities-between March September 2022. A structured questionnaire in-depth interviews were used collect quantitative qualitative data, respectively. total of 1,508...
Estimating human exposure to mosquito vectors is crucial for the prediction of malaria transmission and intervention impact. The landing catch method frequently used directly measure estimate rates; however, there has been an increasing shift from this exposure-free alternatives, such as electrocuting traps (MET) other approaches. While these latter methods can provide robust representative values density, they often still require a volunteer, which poses logistical challenges. Additionally,...
<title>Abstract</title> Background Two billion people globally are using faecal-contaminated water. <italic>E. coli</italic> poses a health risk due to its potential cause diseases which highlights the need for understanding antimicrobial resistance profile and associated factors contamination. Methods A cross-sectional study was conducted in Bagamoyo district council that involved 163 groundwater sources with sanitary inspection isolation of E. coli Membrane filtration method CHROMagar CCA....
The pentavalent is a vaccine against Diphtheria, Pertussis, Tetanus, Hepatitis B, and Haemophilus type B influenza. A child considered vaccination dropout if they have received the first dosage as advised but not obtained third dose. In Tanzania, first-dose receiver of was approximately 97%, whereas only 89% Unfortunately, no studies been done in Tanzania to evaluate factors at national level that are linked with first-versus third-dose dropout; hence, we explored these here for time....
Abstract A pilot implementation of the rapid diagnostic test program was performed to collect evidence feasibility, acceptability, and uptake COVID-19 AgRDT in Tanzania. We conducted a prospective cross-sectional study community provide quantitative details antigen (AgRDT) This undertaken between March 2022 September 2022. The implemented by distributing offering kits people suspected having Dar es Salaam through health workers. total 1039 participants consented participate survey. All...
<title>Abstract</title> Background: Reactive case detection (RACD) for malaria control has been found effective in low transmission settings, but its impact and cost-effectiveness moderate-high settings are unknown. We conducted an economic evaluation alongside empirical trial of a modified RACD strategy (1,7-mRCTR) three high districts Tanzania. Methods: The costs cost-savings associated with the intervention to passive alone were estimated, simulation model was utilized assess terms...
The rapid diagnosis of coronavirus disease 2019 (COVID-19) is critical for comprehensive public health response strategies, and self-testing with antigen diagnostic tests (Ag-RDTs) presents opportunities to test in hard-to-reach communities. Therefore, we evaluated the acceptability, feasibility, uptake Ag-RDT at community level Tanzania. From June October 2022, symptomatic individuals or those recent contact a known suspected COVID-19 patient were offered assisted testing within mining...
Abstract Background Reactive case detection (RACD) for malaria control has been found effective in low transmission settings, but its impact and cost-effectiveness moderate-to-high settings are unknown. We conducted an economic evaluation alongside empirical trial of a modified RACD strategy (1,7-mRCTR) three districts Tanzania. Methods The costs cost savings associated with the intervention relative to passive alone were estimated study sites Kilwa, Kibiti, Rufiji Tanzania from 2019–2021....
Abstract Background Estimating human exposure to mosquito vectors is crucial for prediction of malaria transmission and intervention impact. Human Landing Catches are often direct estimate rates; however there has been an increasing move away from this method exposure-free alternatives such as the Mosquito Electrocuting Traps (MET) other approaches. While methods can provide robust representative values density; they still require a volunteer which poses logistical challenges. Additionally...
Abstract Introduction Insecticide-treated nets (ITNs) specifically long-lasting insecticidal (LLINs) are one of the most commonly used, scalable and cost-effective tools for controlling malaria transmission in sub-Saharan Africa. However, multiple alternative uses retired LLINs have been observed associated with poor disposal practices. Nevertheless, World Health Organisation (WHO) provided guidelines recommendations proper management worn-out LLINs. This study assessed existing practices...