A5088123201- Mosquito-borne diseases and control
- Malaria Research and Control
- Insect Pest Control Strategies
- Global Maternal and Child Health
- Viral Infections and Vectors
- Insect Resistance and Genetics
- Viral Infections and Outbreaks Research
- COVID-19 epidemiological studies
- Insect symbiosis and bacterial influences
- Parasites and Host Interactions
- Tuberculosis Research and Epidemiology
- Species Distribution and Climate Change
- Travel-related health issues
- Insect Utilization and Effects
- Insect-Plant Interactions and Control
- Genetics, Bioinformatics, and Biomedical Research
- Digital Imaging for Blood Diseases
- Invertebrate Immune Response Mechanisms
- International Development and Aid
- Parasite Biology and Host Interactions
- Maternal and fetal healthcare
- Zoonotic diseases and public health
- Insect and Pesticide Research
- Dengue and Mosquito Control Research
- Healthcare Systems and Reforms
Ifakara Health Institute
2016-2025
African Malaria Network Trust
2024
Muhimbili University of Health and Allied Sciences
2023
American Mosquito Control Association
2023
Swiss Tropical and Public Health Institute
2018-2022
Sokoine University of Agriculture
2022
University of Basel
2019-2021
Liverpool School of Tropical Medicine
2012-2017
Abstract Background In 2015, Tanzania National Malaria Control Programme (NMCP) established a longitudinal malaria vector entomological surveillance (MVES). The MVES is aimed at periodical assessment of composition and abundance, feeding resting behaviours, Plasmodium falciparum infection in different epidemiological strata to guide the NMCP on deployment appropriate interventions. This work details dynamics transmission strata. Methods was conducted from 32 sentinel district councils across...
BackgroundIn the city of Dar es Salaam, Tanzania, rapid and spontaneous scale-up window screening occurred through purely horizontal commercial distribution systems without any public subsidies or promotion. Scale-up coincided with a planned evaluation programmatic, vertically managed regular larvicide application as an intervention against malaria vectors transmission. We aimed to establish whether was associated suppression mosquito populations, especially for that strongly prefer humans...
Behaviour changes in mosquitoes from indoor to outdoor biting result continuing risk of malaria activities, including routine household activities and occasional social cultural practices gatherings. This study aimed identify the range gatherings conducted outdoors their associated risks for mosquito bites. A cross-sectional was four villages Kilombero Valley November 2015 March 2016. Observations, focus group discussions, key informant interviews were conducted. The recorded data...
Yearly, a quarter billion people are infected and half million killed by the mosquito-borne disease malaria. Lack of real-time observational tools for continuously assessing unperturbed mosquito flight activity in situ limits progress toward improved vector control. We deployed high-resolution entomological lidar to monitor half-kilometer static transect adjacent Tanzanian village. evaluated one-third insect observations during five nights, four days, one annular solar eclipse. demonstrate...
Abstract Background Strengthening malaria control activities in Tanzania has dramatically declined human infections. However, there is an increasing epidemiological shift the burden on school-age children. The underlying causes for such remain unknown this context. This study explored and behaviours that could increase vulnerability of children to transmission risk provide insight into protection gap with existing interventions opportunities supplementary interventions. Methods...
During the past six decades, remarkable success on malaria control has been made in China. The major experience could be shared with other endemic countries including Tanzania high burden. Especially, China’s 1–3-7 model for elimination is one of most important refined experiences from many years’ efforts and key innovation measures China-UK-Tanzania pilot project was implemented April, 2015 to June, 2018, which an operational research two communities receiving proposed interventions...
Abstract Background In 2015, a China-UK-Tanzania tripartite pilot project was implemented in southeastern Tanzania to explore new model for reducing malaria burden and possibly scaling-out the approach into other malaria-endemic countries. The 1,7-malaria Reactive Community-based Testing Response (1,7-mRCTR) which is locally-tailored reporting febrile cases endemic villages developed stop transmission Plasmodium life-cycle. utilizes existing health facility data locally trained community...
More sensitive and scalable entomological surveillance tools are required to monitor low levels of transmission that increasingly common across the tropics, particularly where vector control has been successful. A large-scale larviciding programme in urban Dar es Salaam, Tanzania is supported by a community-based (CB) system for trapping adult mosquito densities performance. An intensive extensive CB routine, longitudinal, programmatic malaria vectors other mosquitoes using Ifakara Tent Trap...
In the Tanzanian city of Dar es Salaam, high coverage long-lasting insecticidal nets (LLINs), larvicide application (LA) and mosquito-proofed housing, was complemented with improved access to artemisinin-based combination therapy rapid diagnostic tests by end 2012. Three rounds city-wide, cluster-sampled cross-sectional surveys malaria parasite infection status, spanning 2010 2012, were two series high-resolution, longitudinal vector density. Larvicide using a granule formulation Bacillus...
Lack of tools for detailed, real-time observation mosquito behavior with high spatio-temporal resolution limits progress towards improved malaria vector control. We deployed a high-resolution entomological lidar to monitor half-kilometer static transect positioned over rice fields outside Tanzanian village. A quarter million in situ insect observations were classified, and several taxa identified based on their modulation signatures. observed distinct range distributions male female...
Surveys from the China-Tanzania Malaria Control Project demonstrated that 1,7-malaria Reactive Community-Based Testing and Response (1,7-mRCTR) approach significantly reduced malaria incidence rates. However, implementation was disrupted by security concerns, infectious disease outbreaks, supply shortages. This study evaluates how these interruptions affected intervention effectiveness to inform future control strategies. The employed a two-phased design: Phase I (2016-2018) II (2019-2021)....
Malaria is an important public health problem in Tanzania. The latest national malaria data suggests rebound of the disease country. Anopheles arabiensis, a mosquito species renowned for its resilience against existing vector control measures has now outnumbered endophagic and anthrophilic gambiae sensu stricto as dominant vector. Vector measures, prophylaxis case management with artemisinin-based combination therapy (ACT) are main interventions. This paper presents discusses findings from...
Differences in rural and urban settings could account for distinct characteristics the epidemiology of tuberculosis (TB). We comparatively studied epidemiological features TB helminth co-infections adult patients from Tanzania.Adult (≥ 18 years) with microbiologically confirmed pulmonary were consecutively enrolled into two cohorts Dar es Salaam, ~ 4.4 million inhabitants (urban), Ifakara sparsely populated Kilombero District 400 000 (rural). Clinical data obtained at recruitment. Stool...
Abstract Background Insecticide-treated nets (ITNs) and house modifications are proven vector control tools, yet in most regions, full coverage has not been achieved. This study investigates household factors associated with access to ITNs modification Tanzania. Methods Baseline cross-sectional survey data from previous studies on spatial repellants indoor residual spray evaluation was analysed 6757 households Bagamoyo (60 km north of Dar es Salaam) 1241 Ulanga (a remote rural area southeast...
Abstract Background Progress in malaria control has stalled recent years and innovative surveillance response approaches are needed to accelerate elimination efforts endemic areas of Africa. Building on a previous China-UK-Tanzania pilot study control, this aimed assess the impact 1,7-malaria Reactive Community-Based Testing Response (1,7-mRCTR) approach implemented over two three districts Tanzania. Methods The 1,7-mRCTR provides community-based testing via rapid diagnostic tests treatment...
Mosquito feeding behaviour plays a major role in determining malaria transmission intensity and the impact of specific prevention measures. Human Landing Catch (HLC) is currently only method that can directly consistently measure biting rates anthropophagic mosquitoes, both indoors outdoors. However, this exposes participant to mosquito-borne pathogens, therefore new exposure-free methods are needed replace it.Commercially available electrocuting grids (EGs) were evaluated as an alternative...
This study investigated whether passively collected routine health facility data can be used for mapping spatial heterogeneities in malaria transmission at the level of local government housing cluster administrative units Dar es Salaam, Tanzania. From June 2012 to January 2013, residential locations patients tested a public were traced based on their leaders' names and geo-referencing point these houses. Geographic information systems (GIS) visualise distribution infection rates. Spatial...
Background The frequency and magnitude of dengue epidemics has increased dramatically throughout the tropics in past 40 years due to unplanned urbanization, globalization lack effective mosquito control. commercial capital Tanzania, Dar es Salaam, is now experiencing regular outbreaks. Three serotypes have been detected Salaam (DNV 1, 2 3). Without adequate vector monitoring control, further outbreaks will certainly occur. Methods/Findings A case series study followed 97 individuals with...
Malaria transmission, primarily mediated by Anopheles gambiae, persists in Dar es Salaam (DSM) despite high coverage with bed nets, mosquito-proofed housing and larviciding. New or improved vector control strategies are required to eliminate malaria from DSM, but these will only succeed if they delivered the minority of locations where residual transmission actually persists. Hotspots spatially clustered elevated infection prevalence densities were, therefore, mapped across city an attempt...
Geophysical topographic metrics of local water accumulation potential are freely available and have long been known as high-resolution predictors where aquatic habitats for immature Anopheles mosquitoes most abundant, resulting in elevated densities adult malaria vectors human infection burden. Using existing entomological epidemiological survey data, here we illustrate how topography can also be used to map out the interfaces between wet, unoccupied valleys dry, densely populated uplands,...
Abstract Background Host preference is a critical determinant of human exposure to vector-borne infections and the impact vector control interventions. Widespread use long-lasting insecticide-treated nets (LLINs) indoor residual spraying (IRS) across sub-Saharan Africa, which protect humans against mosquitoes, may select for altered host traits malaria vectors over long term. Here, preferences Anopheles arabiensis gambiae sensu stricto (s.s.) were experimentally assessed in field, using...
Abstract Background Routine health facility data provides the opportunity to monitor progress in quality and uptake of care continuously. Our study aimed assess reliability usefulness emergency obstetric including temporal regional variations over past five years Tanzania Mainland. Methods Data were compiled from routine monthly district reports as part management information systems for 2016–2020. Key indicators maternal neonatal coverage, complications, interventions computed. Assessment...
Abstract Background Increased global trade, while beneficial economically, can also increase the spread of vector-borne diseases, particularly those transmitted by Aedes mosquitoes spreading via trade routes. Given heightened trade-induced activity at ports entry, it is crucial to assess risk mosquito-borne diseases in these settings. This study compared risks -borne disease and around eastern Tanzanian seaport Tanga. Methods A 200 m × grid-based system was used sample within port area,...
Objective To assess pathways and associated costs of seeking care from the onset symptoms to diagnosis in patients with confirmed presumptive tuberculosis (TB). Design Cross-sectional study. Setting District hospital Dar es Salaam, Tanzania. Participants Bacteriologically TB patients. Primary secondary outcome measures We calculated distance metres visualised healthcare up five visits for current episode sickness. Costs were described by medians IQRs, comparisons gender poverty status....