A5021455385- Malaria Research and Control
- Mosquito-borne diseases and control
- Computational Drug Discovery Methods
- Drug-Induced Hepatotoxicity and Protection
- Pharmaceutical studies and practices
- Epilepsy research and treatment
- Hemoglobinopathies and Related Disorders
- Global Maternal and Child Health
- Viral Infections and Outbreaks Research
- Pharmacological Effects and Toxicity Studies
- Hematological disorders and diagnostics
Medicines for Malaria Venture
2016-2025
Pyronaridine-artesunate efficacy for the treatment of uncomplicated Plasmodium falciparum malaria was assessed in an area artemisinin resistance western Cambodia. This nonrandomized, single-arm, observational study conducted between 2014 and 2015. Eligible patients were adults or children with microscopically confirmed P. infection fever. Patients received pyronaridine-artesunate once daily 3 days, dosed according to body weight. The primary outcome adequate clinical parasitological response...
ABSTRACT Piperaquine tetraphosphate (PQP), a long‐acting antimalarial, is being considered in combination for chemoprevention. Dihydroartemisinin‐piperaquine tablets (hard and dispersible) approved the treatment of acute uncomplicated malaria should be administered fasted state, as PQP bioavailability increases with food. A new taste‐masked dispersible granules formulation aims to minimize impact food on drug exposure. This randomized, open label, parallel group, Phase I pilot study was...
Drug resistance to sulfadoxine-pyrimethamine and amodiaquine threatens the efficacy of malaria chemoprevention interventions in children pregnant women. Combining pyronaridine (PYR) piperaquine (PQP), both components approved antimalarial therapies, has potential protect vulnerable populations from severe malaria. This randomized, double-blind, placebo-controlled (double-dummy), parallel-group, single site phase I study healthy adult males or females Black sub-Saharan African ancestry...
Global health, particularly in underserved settings can benefit immensely from well-trained community health workers (CHWs) supporting primary healthcare interventions. They reduce morbidity and mortality of infectious diseases like malaria. Disease control programs a tight link between CHWs communities several studies have shown the participation non-facility-based malaria program activities for reducing malaria-related children. Because are often part trusted by served communities, they...