A5023161333- Malaria Research and Control
- Mosquito-borne diseases and control
- Statistical Methods and Bayesian Inference
- Statistical Methods in Clinical Trials
- Statistical Methods and Inference
- SARS-CoV-2 and COVID-19 Research
- Advanced Causal Inference Techniques
- Computational Drug Discovery Methods
- Eosinophilic Disorders and Syndromes
- Parasites and Host Interactions
- Vaccine Coverage and Hesitancy
- Eosinophilic Esophagitis
- Research on Leishmaniasis Studies
- COVID-19 Clinical Research Studies
- Trypanosoma species research and implications
- Advanced Statistical Methods and Models
- Hepatitis B Virus Studies
- Parasitic Diseases Research and Treatment
- Viral Infections and Vectors
- Complement system in diseases
- Health Systems, Economic Evaluations, Quality of Life
- vaccines and immunoinformatics approaches
- Statistical Distribution Estimation and Applications
- Optimal Experimental Design Methods
- SARS-CoV-2 detection and testing
Queen's University
2025
National Institute of Allergy and Infectious Diseases
2015-2024
National Institutes of Health
2015-2024
Mater Misericordiae University Hospital
2017-2024
University College Dublin
2022-2024
Walter Reed Army Institute of Research
2023
Government of the United States of America
2021
National Institute on Drug Abuse
2021
Saint Michael's College
2014
Cancer Research And Biostatistics
2009-2013
A Correction has been published for this article in Statistics Medicine 2001; 20:655. The identification of changes the recent trend is an important issue analysis cancer mortality and incidence data. We apply a joinpoint regression model to describe such continuous use grid-search method fit function with unknown joinpoints assuming constant variance uncorrelated errors. find number significant by performing several permutation tests, each which correct significance level asymptotically....
In a mathematical approach to hypothesis tests, we start with clearly defined set of hypotheses and choose the test best properties for those hypotheses. practice, often less precise For example, researcher wants know which two groups generally has larger responses, either t-test or Wilcoxon-Mann-Whitney (WMW) could be acceptable. Although both t-tests WMW tests are usually associated quite different hypotheses, decision rule p-value from many sets assumptions, call perspectives. It is...
Infection with the obligate intracellular protozoan Leishmania is thought to be initiated by direct parasitization of macrophages, but early events following transmission skin vector sand flies have been difficult examine directly. Using dynamic intravital microscopy and flow cytometry, we observed a rapid sustained neutrophilic infiltrate at localized fly bite sites. Invading neutrophils efficiently captured major (L.m.) parasites after or needle inoculation, phagocytosed L.m. remained...
We offer an approximation to central confidence intervals for directly standardized rates, where we assume that the rates are distributed as a weighted sum of independent Poisson random variables. Like recent method proposed by Dobson, Kuulasmaa, Eberle and Scherer, our gives exact whenever standard population is proportional study population. In cases two populations differ non-proportionally, show through simulation conservative while other methods (the Dobson et al. approximate bootstrap...
Background Pfs25 and Pvs25, surface proteins of mosquito stage the malaria parasites P. falciparum vivax, respectively, are leading candidates for vaccines preventing transmission by mosquitoes. This single blinded, dose escalating, controlled Phase 1 study assessed safety immunogenicity recombinant Pvs25 formulated with Montanide ISA 51, a water-in-oil emulsion. Methodology/Principal Findings The trial was conducted at Johns Hopkins Center Immunization Research, Washington DC, USA, between...
A Correction has been published for this article in Statistics Medicine 2001; 20:655. The identification of changes the recent trend is an important issue analysis cancer mortality and incidence data. We apply a joinpoint regression model to describe such continuous use grid-search method fit function with unknown joinpoints assuming constant variance uncorrelated errors. find number significant by performing several permutation tests, each which correct significance level asymptotically....
For right-censored data perhaps the most commonly used tests are weighted logrank tests, such as and Wilcoxon-type tests. In this paper we review several generalizations of those to interval-censored present an <b>R</b> package, <b>interval</b>, implement many them. The <b>interval</b> package depends on <b>perm</b> also presented here, which performs exact asymptotic linear permutation included in already available <b>coin</b> provides independent validation <b>coin</b>. We analysis methods...
Hypereosinophilic syndrome is a group of diseases defined by marked eosinophilia in blood or tissue and eosinophil-related clinical manifestations. Benralizumab monoclonal antibody against interleukin-5 receptor α, which expressed on human eosinophils.
The extent of SARS-CoV-2 infection throughout the United States population is currently unknown. High quality serology key to avoiding medically costly diagnostic errors, as well assuring properly informed public health decisions. Here, we present an optimized ELISA-based protocol, from antigen production data analyses, that helps define thresholds for IgG and IgM seropositivity with high specificities. Validation this protocol performed using traditionally collected serum dried blood on...
16.8 million SARS-CoV-2 infections in the US went undiagnosed first 6 months of pandemic compared to 3.5 diagnosed infections.
Summary Segmented line regression models, which are composed of continuous linear phases, have been applied to describe changes in rate trend patterns. In this article, we propose a procedure compare two segmented functions, specifically test (i) whether the functions identical or (ii) mean parallel allowing different intercepts. A general form statistic is described and then permutation proposed estimate p‐value test. The compared an approximate F ‐test terms estimation performance studied...
The sandwich estimator of variance may be used to create robust Wald-type tests from estimating equations that are sums K independent or approximately terms. For example, for repeated measures data on individuals, each term relates a different individual. These applied parameter have greater than nominal size if is small, more generally the tested essentially estimated small number terms in equation. We offer some practical modifications these tests, which asymptotically approach usual...
Chloroquine (CQ) resistance (CQR) in Plasmodium falciparum originated from at least six foci South America, Asia, and Oceania. Malaria parasites these locations exhibit contrasting phenotypes that are distinguished by point mutations microsatellite polymorphisms near the CQR transporter gene, pfcrt, multidrug pfmdr1. Amodiaquine (AQ), a 4-aminoquinoline related to CQ, is recommended often used successfully against CQ-resistant P. Africa, but it largely ineffective across large regions of...
There is an inherent relationship between two-sided hypothesis tests and confidence intervals.A series of may be inverted to obtain the matching 100(1-α)% interval defined as smallest that contains all point null parameter values would not rejected at α level.Unfortunately, for discrete data there are several different ways defining exact most commonly used twosided one way, while intervals inversions another way.This can lead inconsistencies where test rejects but value.The packages exactci...
The annual percent change (APC) is often used to measure trends in disease and mortality rates, a common estimator of this parameter uses linear model on the log age-standardized rates. Under assumption linearity scale, which equivalent constant assumption, APC can be equivalently defined three ways as transformations either (1) slope line that runs through each rate, (2) ratio last rate first series, or (3) geometric mean proportional changes rates over series. When fails then definition...
Background. West Nile virus (WNV) is a mosquitoborne flavivirus that can cause severe meningitis and encephalitis in infected individuals. We report the safety immunogenicity of WNV DNA vaccine its first phase 1 human study. Methods. Asingle-plasmidDNAvaccine encoding premembrane envelope glycoproteins NY99 strain was evaluated an open-label study 15 healthy adults. Twelve subjects completed 3-dose vaccination schedule, all 32 weeks evaluation for immunogenicity. The development...
Leishmaniasis is transmitted between mammalian hosts by the bites of bloodsucking vector sand flies. The dose parasites to host has never been directly determined. We developed a real-time PCR-based method determine number Leishmania major inoculated into ears living mice during feeding individual infected flies ( Phlebotomus duboscqi ). varied over wide range in 58 which were detected and demonstrated clear bimodal distribution. Most with low <600 parasites. One four received higher...
ATP-binding cassette transporters play an important role in drug resistance and nutrient transport. In the human malaria parasite Plasmodium falciparum, a homolog of p-glycoprotein (PfPgh-1) was shown to be involved several drugs. More recently, many were associated with higher IC50 levels responses chloroquine (CQ) quinine (QN) field isolates. Subsequent studies, however, could not confirm associations, although inaccuracy tests later studies contribute lack associations. Here we disrupted...
When analyzing a 2 x table, the two-sided Fisher's exact test and usual confidence interval (CI) for odds ratio may give conflicting inferences; example, rejects but associated CI contains an of 1. The problem is that inversion if either one-sided tests at half nominal significance level. Further, set not be interval, so following Blaker (2000, Confidence curves improved intervals discrete distributions. Canadian Journal Statistics 28, 783-798), we define "matching" as smallest set. We...