A5053362604- Cardiac and Coronary Surgery Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Pleural and Pulmonary Diseases
- Sepsis Diagnosis and Treatment
- Cardiac Valve Diseases and Treatments
- Acute Ischemic Stroke Management
- Emergency and Acute Care Studies
- Occupational and environmental lung diseases
- Hemodynamic Monitoring and Therapy
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cerebrovascular and Carotid Artery Diseases
- Healthcare Technology and Patient Monitoring
- Maternal and fetal healthcare
- Mechanical Circulatory Support Devices
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Mosquito-borne diseases and control
- Ultrasound in Clinical Applications
- Malaria Research and Control
- Traumatic Brain Injury and Neurovascular Disturbances
- Amoebic Infections and Treatments
- Lung Cancer Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Coronary Interventions and Diagnostics
- Aortic Disease and Treatment Approaches
University of Oxford
2016-2025
Nuffield Orthopaedic Centre
2016-2025
Bates College
2024
NIHR Biomedical Research Centre at The Royal Marsden and the ICR
2020
National Institute for Health Research
2020
Guy's and St Thomas' NHS Foundation Trust
2020
Newcastle upon Tyne Hospitals NHS Foundation Trust
2020
Community Link
2020
Oxford BioMedica (United Kingdom)
2020
King's College London
2020
Multiple arterial grafts may result in longer survival than single after coronary-artery bypass grafting (CABG) surgery. We evaluated the use of bilateral internal-thoracic-artery for CABG.
The use of bilateral internal thoracic (mammary) arteries for coronary-artery bypass grafting (CABG) may improve long-term outcomes as compared with the a single internal-thoracic-artery plus vein grafts.
Background The Alberta Stroke Program Early Computed Tomography Score (ASPECTS) is an established 10-point quantitative topographic computed tomography scan score to assess early ischemic changes. We performed a non-inferiority trial between the e-ASPECTS software and neuroradiologists in scoring ASPECTS on non-contrast enhanced images of acute stroke patients. Methods In this multicenter study, three independent retrospectively blindly assessed baseline 132 patients with anterior...
The Alberta Stroke Program Early CT score (ASPECTS) is an established 10-point quantitative topographic computed tomography scan to assess early ischemic changes. We compared the performance of e-ASPECTS software with those stroke physicians at different professional levels.The baseline scans acute patients, in whom and diffusion-weighted imaging were obtained less than two hours apart, retrospectively scored by as well three experts neurology trainees blinded any clinical information....
To compare the ability of National Early Warning Score (NEWS) and 2 (NEWS2) to identify patients at risk in-hospital mortality other adverse outcomes.We undertook a multi-centre retrospective observational study five acute hospitals from two UK NHS Trusts. Data were obtained completed adult admissions who not fit enough be discharged alive on day admission. Diagnostic coding oxygen prescriptions used with type II respiratory failure (T2RF). The primary outcome was within 24 h vital signs...
Background. Circumsporozoite protein (CS) is the antigenic target for RTS,S, most advanced malaria vaccine to date. Heterologous prime-boost with viral vectors simian adenovirus 63 (ChAd63)-modified vaccinia virus Ankara (MVA) potent inducer of T-cells in humans, demonstrating significant efficacy when expressing preerythrocytic antigen insert multiple epitope–thrombospondin-related adhesion (ME-TRAP). We hypothesized that ChAd63-MVA containing CS may result a clinical protective efficacy.
AimsAngiotensin-converting enzyme (ACE) inhibitors improve left ventricular (LV) remodelling and outcome in heart failure hypertensive disease. They may be similarly beneficial patients with aortic stenosis (AS), but historical safety concerns have limited their use, no prospective clinical trials exist.
Controlled human malaria infection (CHMI) studies are a vital tool to accelerate vaccine and drug development. As CHMI trials performed in controlled environment, they allow unprecedented, detailed evaluation of parasite growth dynamics (PGD) immunological responses. However, have not been routinely malaria-endemic countries or used investigate mechanisms naturally-acquired immunity (NAI) Plasmodium falciparum.We conducted an open-label, randomized pilot-study using aseptic, cryopreserved P....
To estimate normal ranges for maternal vital signs throughout pregnancy, which have not been well defined in a large contemporary population.We conducted three-center, prospective, longitudinal cohort study the United Kingdom from August 2012 to September 2017. We recruited women at less than 20 weeks of gestation without significant comorbidities with accurately dated singleton pregnancies. measured participants' blood pressure (BP), heart rate, respiratory oxygen saturation and temperature...
BackgroundPrimary spontaneous pneumothorax occurs in otherwise healthy young patients. Optimal management is not defined and often results prolonged hospitalisation. Data on efficacy of ambulatory options are poor. We aimed to describe the duration hospitalisation safety compared with standard care.MethodsIn this open-label, randomised controlled trial, adults (aged 16–55 years) symptomatic primary were recruited from 24 UK hospitals during a period 3 years. Patients randomly assigned (1:1)...
Background. The need for a highly efficacious vaccine against Plasmodium falciparum remains pressing. In this controlled human malaria infection (CHMI) study, we assessed the safety, efficacy and immunogenicity of schedule combining 2 distinct types in staggered immunization regimen: one inducing high-titer antibodies to circumsporozoite protein (RTS,S/AS01B) other potent T-cell responses thrombospondin-related adhesion (TRAP) by using viral vector. Method. Thirty-seven healthy malaria-naive...
Postoperative atrial fibrillation (pAF) after coronary artery bypass grafting is a common complication. Whether pAF associated with an increased risk of cerebrovascular accident (CVA) remains uncertain. We investigated the association between and long-term CVA by performing post hoc analysis 10-year outcomes ART (Arterial Revascularization Trial).For present analysis, among patients enrolled in (n=3102), we excluded those who did not undergo surgery (n=25), had history (n=45), or no...
Computed tomography angiography (CTA) collateral scoring can identify patients most likely to benefit from mechanical thrombectomy and those more have good outcomes ranges 0 (no collaterals) 3 (complete collaterals). In this study, we used a machine learning approach categorise the degree of flow in 98 who were eligible for generate an e-CTA score (CTA-CS) each patient (e-STROKE SUITE, Brainomix Ltd., Oxford, UK). Three experienced neuroradiologists (NRs) independently estimated CTA-CS,...
Background Over 30% of adult patients with pleural infection either die and/or require surgery. There is no robust means predicting at baseline presentation which will suffer a poor clinical outcome. A validated risk prediction score would allow early identification high-risk patients, potentially directing more aggressive treatment thereafter. Objectives To prospectively assess previously described (the RAPID (Renal (urea), Age, fluid Purulence, Infection source, Dietary (albumin)) score)...