A5060938048- Dementia and Cognitive Impairment Research
- Cholinesterase and Neurodegenerative Diseases
- Neurological Disorders and Treatments
- Neurological Disease Mechanisms and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Colorectal Cancer Screening and Detection
- Alzheimer's disease research and treatments
- Folate and B Vitamins Research
- Maternal and fetal healthcare
- Ginkgo biloba and Cashew Applications
- Inflammatory Biomarkers in Disease Prognosis
- Pregnancy and preeclampsia studies
- Emergency and Acute Care Studies
- Diabetes Management and Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Gestational Diabetes Research and Management
- Mobile Health and mHealth Applications
- Trauma and Emergency Care Studies
- Sepsis Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Metabolism and Genetic Disorders
- Cardiovascular Issues in Pregnancy
- Vascular Malformations Diagnosis and Treatment
- Neonatal Respiratory Health Research
University of Oxford
2015-2024
Nuffield Orthopaedic Centre
2006-2024
Office for National Statistics
2018-2023
National Institute for Health Research
2016-2020
NIHR Biomedical Research Centre at The Royal Marsden and the ICR
2020
King's College London
2020
Newcastle upon Tyne Hospitals NHS Foundation Trust
2020
Oxford University Hospitals NHS Trust
2020
Community Link
2020
Guy's and St Thomas' NHS Foundation Trust
2020
BackgroundOur aim was to assess the long-term risks of death, disability, and rebleeding in patients randomly assigned clipping or endovascular coiling after rupture an intracranial aneurysm follow-up International Subarachnoid Aneurysm Trial (ISAT).Methods2143 with ruptured aneurysms were enrolled between 1994 2002 at 43 neurosurgical centres coiling. Clinical outcomes 1 year have been previously reported. All UK some non-UK continued 2004 original cohort. Annual has done for a minimum 6...
Valvular heart disease (VHD) is expected to become more common as the population ages. However, current estimates of its natural history and prevalence are based on historical studies with potential sources bias. We conducted a cross-sectional analysis clinical epidemiological characteristics VHD identified at recruitment large cohort older people.We enrolled 2500 individuals aged ≥65 years from primary care screened for undiagnosed using transthoracic echocardiography. Newly (predominantly...
Introduction Flow diversion is a new approach to the endovascular treatment of intracranial aneurysms which uses high density mesh stent induce sac thrombosis. These devices have been designed for complex shaped and large size aneurysms. So far published safety efficacy data on this sparse. Material Methods Over 8 months, standardized clinical angiographic were collected 70 patients treated with flow diverter device (SILK (SFD)) in 18 centres worldwide. Treatment early follow up details...
Treatment of hyperglycemia in women with gestational diabetes mellitus (GDM) is associated improved maternal and neonatal outcomes requires intensive clinical input. This currently achieved by hospital clinic attendance every 2 to 4 weeks limited opportunity for intervention between these visits.We conducted a randomized controlled trial determine whether the use mobile phone-based real-time blood glucose management system manage GDM remotely was as effective controlling standard care...
Objectives: to examine the prevalence of vitamin B12 deficiency and folate in later life representative samples elderly population United Kingdom. Design: a population-based cross-sectional analysis 3,511 people aged 65 years or older from three studies was used estimate age-specific deficiency. Vitamin is conventionally diagnosed if serum < 150 pmol/l (‘low B12’). We defined ‘metabolically significant deficiency’ as 200 blood total homocysteine >20 μmol/l. Folate deficiency, which usually...
low vitamin B12 concentrations are common in older people, but the clinical relevance of biochemical evidence deficiency absence anaemia is uncertain.to examine associations cognitive impairment, depression and neuropathy with blood measurements folate status people.cross-sectional study general practice Banbury, England.a total 1,000 individuals aged 75 years or living community.low were identified 13% people associated memory impairment depression. After adjustment for age, sex smoking,...
To estimate normal ranges for maternal vital signs throughout pregnancy, which have not been well defined in a large contemporary population.We conducted three-center, prospective, longitudinal cohort study the United Kingdom from August 2012 to September 2017. We recruited women at less than 20 weeks of gestation without significant comorbidities with accurately dated singleton pregnancies. measured participants' blood pressure (BP), heart rate, respiratory oxygen saturation and temperature...