A5051206783- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Advanced MRI Techniques and Applications
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lanthanide and Transition Metal Complexes
- Stroke Rehabilitation and Recovery
- Traumatic Brain Injury and Neurovascular Disturbances
- Venous Thromboembolism Diagnosis and Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Advanced Neuroimaging Techniques and Applications
- Electron Spin Resonance Studies
- MRI in cancer diagnosis
- Atomic and Subatomic Physics Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Medical Imaging and Analysis
- Neurological Disease Mechanisms and Treatments
- Neurological Disorders and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Lung Cancer Diagnosis and Treatment
- Brain Tumor Detection and Classification
- Peripheral Artery Disease Management
- Systemic Sclerosis and Related Diseases
- Medical Imaging and Pathology Studies
University of Oxford
2016-2025
Brainomix (United Kingdom)
2018-2025
Oxford University Hospitals NHS Trust
2019-2025
National Health Service
2022-2024
Oxford Health NHS Foundation Trust
2019-2023
Resonance Research (United States)
2022
Campbell Collaboration
2021
John Radcliffe Hospital
2013-2018
Imaging Center
2018
Oxford BioMedica (United Kingdom)
2016
The original concept of the ischaemic penumbra suggested imaging regional cerebral blood flow and metabolism would be required to identify tissue that may benefit from intervention. Amide proton transfer magnetic resonance imaging, a chemical exchange saturation technique, has been used derive intracellular pH in preclinical stroke models proposed as metabolic marker penumbra. In this proof principle clinical study, we explored potential pH-weighted technique at tissue-level. Detailed...
Amide proton transfer (APT) imaging is a pH mapping method based on the chemical exchange saturation phenomenon that has potential for penumbra identification following stroke. The majority of literature thus far focused generating pH-weighted contrast using magnetization ratio asymmetry analysis instead quantitative mapping. In this study, widely used and model-based were both assessed APT data collected from healthy subjects (n = 2) hyperacute stroke patients 6, median time after onset 2...
Computed tomography angiography (CTA) collateral scoring can identify patients most likely to benefit from mechanical thrombectomy and those more have good outcomes ranges 0 (no collaterals) 3 (complete collaterals). In this study, we used a machine learning approach categorise the degree of flow in 98 who were eligible for generate an e-CTA score (CTA-CS) each patient (e-STROKE SUITE, Brainomix Ltd., Oxford, UK). Three experienced neuroradiologists (NRs) independently estimated CTA-CS,...
Mechanical thrombectomy greatly improves stroke outcomes. Nonetheless, some patients fall short of full recovery despite good reperfusion. The purpose this study was to develop machine learning (ML) models for the pre-interventional prediction functional outcome at 3 months in acute ischemic (AIS), using clinical and auto-extractable radiological information consistently available upon first emergency evaluation.A two-center retrospective cohort 293 with AIS who underwent analyzed. ML were...
Amide proton transfer (APT) imaging may help identify the ischaemic penumbra in stroke patients, classical definition of which is a region tissue around core that hypoperfused and metabolically stressed. Given potential APT to complement existing techniques provide clinically-relevant information, there need develop analysis deliver robust repeatable metric. The challenge accurate quantification an metric has been heterogeneous in-vivo environment human tissue, exhibits several confounding...
Background and Purpose: The e-Stroke Suite software (Brainomix, Oxford, United Kingdom) is a tool designed for the automated quantification of Alberta Stroke Program Early CT Score ischemic core volumes on noncontrast computed tomography (NCCT). We sought to compare prediction postreperfusion infarct clinical outcomes across NCCT versus RAPID (IschemaView, Menlo Park, CA) perfusion measurements. Methods: All consecutive patients with anterior circulation large vessel occlusion stroke...
This narrative review provides an overview of the posterior circulation and clinical features common stroke (PCS) syndromes in arterial territories how to distinguish them from mimics. We outline hyperacute management patients with suspected PCS emphasis on identify those who are likely benefit intervention based imaging findings. Finally, we advances treatment options, including developments endovascular thrombectomy (EVT) intravenous thrombolysis (IVT), principles medical indications for...
Background: Identifying optimal candidates for endovascular treatment (EVT) remains an ongoing priority to maximize efficacy. The recent large core trials have called into question the use of infarct volume alone selecting patients. This study aimed at exploring feasibility using routinely acquired Computed Tomography Perfusion (CTP) capture how lesion location impacts brain connectivity and this in turn affects ability benefit from EVT. Methods: Consecutive patients a multi-centric stroke...
Introduction: AI imaging decision support software is recommended by UK and USA stroke guidelines to facilitate identification transfer of patients eligible for endovascular therapy (EVT) but the impact on thrombectomy delivery unclear. This prospective observational study evaluated Brainomix 360 Stroke in four networks (28 hospitals) England’s National Health Service (NHS). The primary outcome was percentage acute receiving EVT (the rate); door-in door-out (DIDO) times were assessed as a...
Background: Acute stroke lesions become more hypodense on non-contrast CT as the ischemic injury matures. Lesions transition to established infarcts at which time recanalization treatment is thought be futile, if not harmful. As it possible directly quantify degree of progression, eligibility for determined using temporal criteria. In this study we used an AI approach segment and hypoattenuation acute baseline CTs, explored its impact clinical outcome following mechanical thrombectomy....
Background: There is an unmet need to better understand the likelihood of a good functional outcome in older and frailer populations undergoing endovascular therapy (EVT) following large-vessel occlusion (LVO) ischemic stroke. One approach improve understanding pre-morbid brain health (“brain frailty”) as predictor outcome. This study explored relationship between spatial pattern atrophy determine whether this outcomes EVT. Methods: Patients with LVO from four hospitals Europe USA were...
Introduction: Cathodal transcranial direct current stimulation (C-tDCS) is a potential neuroprotective method in the hyperacute phase of ischemic stroke. In rodent models, C-tDCS reduced final infarct volume and improved functional outcome. Our aim was to assess safety, tolerability, feasibility, efficacy stroke patients with salvageable penumbra. Methods: study single-center, double-blind, randomized, sham-controlled (3 active: 1 sham), 3+3 dose-escalation trial. Inclusion criteria were due...
Background: Artificial intelligence (AI) stroke imaging software is becoming mainstay in many hub-and-spoke hospitals. Brainomix 360 Stroke the market leader Europe focused on leveraging simple (non-contrast computerized topography (NCCT) and CT angiography (CTA)) has recently been FDA-cleared for use USA. We evaluated implementation of AI 17 spoke, multi-state Mayo Clinic Health System (MCHS) telestroke network. Methods: This prospective study compared decision treatment times before after...
Abstract Objectives We assessed the impact of artificial intelligence software (e-CTA, Brainomix) on clinical decision-making in patients with suspected acute ischemic stroke. Methods A retrospective, multi-reader-multi-case crossover design compared readers' performance versus without support. Twenty cases were included, 10 large vessel occlusion (LVO) and LVO. one NHS clinicians, representing intended users ranging experience, conducted two sessions (washout period >2 weeks). In...
This study hypothesized that Cerebrolysin, a neuroprotective agent, enhances the efficacy and safety of mechanical thrombectomy (MT) in selected patients with good collateral status effective recanalization. Methods: A single-center, prospective, open-label, single-arm blinded outcome assessment 50 consecutive moderate-to-severe AIS treated MT ≤6 hours stroke onset followed by Cerebrolysin (30 ml iv within 8 continued to day 21, first cycle) recovery phase (between 69-90 days, second...
Follow-up infarct volume (FIV) is a proposed surrogate endpoint for proof-of-concept clinical studies in acute ischemic stroke (AIS). This study aimed to provide validation of an automated FIV algorithm, demonstrating the association imaging biomarkers with outcomes support use these endpoints trials. Data were gathered adult AIS patients undergoing mechanical thrombectomy follow-up 12-96 h from initial assessment. Non-contrast computed tomography was used quantify volume. Image processing...
Corticospinal tract (CST) integrity can predict motor outcome after stroke but requires specialist investigations not routinely performed intracerebral haemorrhage (ICH). We investigated the feasibility of identifying CST on routine clinical CT scans, and whether classification overlap with haematoma is associated recovery ICH. An expert observer, blinded to outcome, manually segmented at posterior limb internal capsule (PLIC) corona radiata (CR) diagnostic scans from 98 randomly selected...
Desert locusts (Schistocerca gregaria) can transform reversibly between the swarming gregarious phase and a solitarious phase, which avoids other locusts. This transformation entails dramatic changes in morphology, physiology, behavior. We have used lobula giant movement detector (LGMD) its postsynaptic target, descending contralateral (DCMD), are visual interneurons that detect looming objects, to analyze how differences ecology of two phases served by altered neuronal function. Solitarious...
Perfusion-weighted imaging is used to select patients with acute ischemic stroke for intervention, but knowledge of cerebral perfusion can also inform the understanding injury. Arterial spin labeling allows repeated measurement absolute blood flow (CBF) without need exogenous contrast. The aim this study was explore relationship between dynamic CBF and tissue outcome in month after onset.Patients nonlacunar underwent ≤5 magnetic resonance scans at presentation, 2 hours, 1 day, week, month....