A5006683717- Asthma and respiratory diseases
- Advanced Chemical Sensor Technologies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Allergic Rhinitis and Sensitization
- Air Quality and Health Impacts
- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Respiratory and Cough-Related Research
- Gas Sensing Nanomaterials and Sensors
- Analytical Chemistry and Chromatography
- Emergency and Acute Care Studies
- Climate Change and Health Impacts
- Birth, Development, and Health
- Food Allergy and Anaphylaxis Research
- Analytical Chemistry and Sensors
- Epigenetics and DNA Methylation
- Breastfeeding Practices and Influences
- Pneumonia and Respiratory Infections
- Noise Effects and Management
- Inhalation and Respiratory Drug Delivery
- Urban Transport and Accessibility
- Pediatric health and respiratory diseases
- COVID-19 and healthcare impacts
- Nosocomial Infections in ICU
- COVID-19 Clinical Research Studies
Canterbury District Health Board
2011-2024
Christchurch Hospital
2013-2023
National Council for Palliative Care
2022
University of Otago
2007-2021
Google (United States)
2020
The Kids Research Institute Australia
1999-2017
The University of Western Australia
2002-2017
Sørlandet Sykehus
2016
Christchurch Clinical Studies Trust
1997-2012
Auckland City Hospital
2008-2010
Higher maternal intake of vitamin D during pregnancy is associated with a lower risk wheezing in offspring. The relationship between cord-blood levels 25-hydroxyvitamin (25[OH]D) and childhood unknown. We hypothesized that would be inversely respiratory infection, wheezing, asthma.Cord blood from 922 newborns was tested for 25(OH)D. Parents were asked if their child had history infection at 3 months age or 15 then annually thereafter. Incident asthma defined as doctor-diagnosed by the time 5...
BACKGROUND: Community acquired pneumonia remains an important cause of hospital admission and carries appreciable mortality. Criteria for the assessment severity during have been developed by British Thoracic Society (BTS). A study was performed to determine sensitivity specificity a rule based on modification BTS prognostic rules applied admission, compare as assessed medical staff with modified rule, microbiological community in Christchurch. METHODS: 12 month all adults admitted...
Pseudomonas aeruginosa infections are associated with progressive life threatening decline of lung function in cystic fibrosis sufferers. Growth Ps. releases a "grape-like" odour that has been identified as the microbial volatile organic compound 2-aminoacetophenone (2-AA).We investigated 2-AA for its specificity to and suitability potential breath biomarker colonisation or infection by Solid Phase Micro Extraction Gas Chromatography-Mass Spectrometry (GC/MS).Cultures 20 clinical strains but...
Importance Chronic breathlessness is common in people with chronic obstructive pulmonary disease (COPD). Regular, low-dose, extended-release morphine may relieve breathlessness, but evidence about its efficacy and dosing needed. Objective To determine the effect of different doses on worst COPD after 1 week treatment. Design, Setting, Participants Multicenter, double-blind, placebo-controlled randomized clinical trial including (defined as a modified Medical Research Council score 3 to 4)...
Adverse respiratory effects of particulate air pollution have been identified by epidemiological studies. We aimed to examine the health ambient from wood burning on school-age students in Christchurch, New Zealand, and explore utility urine exhaled breath condensate biomarkers exposure this population.A panel study 93 male (26 with asthma) living boarding house a metropolitan school was undertaken winter 2004. Indoor outdoor data continuously monitored. Longitudinal assessment lung function...
Chronic obstructive pulmonary disease (COPD) is the single greatest risk factor for lung cancer in smokers and found 50–90% of cases. The link between COPD may stem part from matrix remodelling repair processes underlying COPD, development epithelial–mesenchymal transition (EMT) that underlies carcinogenesis. Hedgehog-interacting protein (HHIP), which mediates epithelial response to smoking, has been implicated cancer. Recent genome-wide candidate gene studies implicate genetic variants on...
<h3>Objectives</h3> Although gluten avoidance is thought to be common among New Zealanders, the prevalence of and actual coeliac disease (CD) in children uncertain. Our aims were: (1) determine doctor-diagnosed CD Zealand children; (2) without CD, identify independent predictors avoidance. <h3>Design</h3> The Asthma Allergy Cohort Study has detailed information on participants9 demographic, pregnancy-related neonatal factors. authors surveyed parents regarding their child9s history lactose...
Aspergillus fumigatus produces 2-Pentylfuran (2-PF) when cultured on blood agar, nutrient agar and other media. As 2-PF is not known to be produced by mammalian metabolism we hypothesized that it detectable in breath of patients colonized or infected with A. fumigatus. Breath was tested for from normal subjects, those undergoing chemotherapy, adults at risk colonization infection because bronchiectasis, cystic fibrosis, immune suppression. samples were collected five L tedlar bags analyzed...
Recently, several large genome-wide association studies have identified a putative “lung cancer” locus in the nicotinic acetylcholine receptor subunit genes (nAChR) on 15q25. However, these findings may be confounded by presence of chronic obstructive pulmonary disease (COPD), which is also strongly associated with smoking exposure and lung cancer. This likely as prevalence COPD cancer cohorts much two-fold greater than that reported control populations (50 versu s 20%). The present authors...
Epidemiological studies show that approximately 20–30% of chronic smokers develop obstructive pulmonary disease (COPD) while 10–15% lung cancer. COPD pre-exists cancer in 50–90% cases and has a heritability 40–77%, much greater than for with 15–25%. These data suggest susceptible to may also be This study examines the association several overlapping chromosomal loci, recently implicated by GWA COPD, function cancer, (n = 1400) subjects sub-phenotyped presence matched smoking exposure. Using...
BACKGROUND: Much remains unknown about the consequences of very low birth weight (VLBW) and bronchopulmonary dysplasia (BPD) on adult lungs. We hypothesized that VLBW adults would have impaired lung function compared with controls, those a history BPD worse than without. METHODS: At age 26 to 30 years, 226 survivors New Zealand cohort 100 term controls born in 1986 underwent tests including spirometry, plethysmographic volumes, diffusing capacity for carbon monoxide, single-breath nitrogen...
Objective and background: The role of COPD self‐management plans in improving health outcomes remains unclear. objective this study was to assess whether administered primary care have beneficial effects on quality life, self‐care behaviour the long term for patients with COPD. Material, methods: a prospective, unblinded, randomized controlled trial usual vs. plus structured education use written plan patient‐initiated short courses antibiotics oral corticosteroids. conducted general...
Summary Background In general, studies reporting positive associations between antibiotic exposure and respiratory allergic disease have been unable to determine the nature of this association. Objective To examine association in infancy development asthma, eczema atopy early childhood. Methods a birth cohort study, we collected reported before 3 months 15 along with outcomes (wheeze, eczema, rash, inhaler use) at ( n =1011) 4 years =986). Atopy was measured using skin prick tests months....
Predicting corticosteroid response in COPD is important but difficult. Response more likely to occur association with eosinophilic airway inflammation, for which the fraction of exhaled nitric oxide (Fe(NO)) a good surrogate marker.We aimed establish whether Fe(NO) levels would predict clinical oral COPD.We performed double-blind, crossover trial steroid patients COPD. After 4-week washout inhaled steroids, received prednisone 30 mg/d or matching placebo, random order, an intervening...
Selected ion flow tube-mass spectrometry (SIFT-MS) can measure volatile compounds in breath on-line real time and has the potential to provide accurate tests for a number of inflammatory, infectious metabolic diseases, including diabetes. Breath concentrations acetone type 2 diabetic subjects undertaking long-term dietary modification programme were studied. Acetone 38 with diabetes determined by SIFT-MS. Anthropomorphic measurements, intake medication use recorded. Blood was analysed beta...
Despite evidence of a relationship among obstructive sleep apnea (OSA), metabolic dysregulation, and diabetes, it is uncertain whether OSA treatment can improve parameters. We sought to determine effects long-term continuous positive airway pressure (CPAP) on glycemic control diabetes risk in patients with cardiovascular disease (CVD) OSA.Blood, medical history, personal data were collected substudy 888 participants the Sleep Apnea cardioVascular Endpoints (SAVE) trial which stable CVD...
Roll-your-own (RYO) cigarettes have increased in popularity, yet their comparative potential toxicity is uncertain. This study compares smoking of RYO and factory-made (FM) on pattern immediate toxicity. At a research clinic, 26 22 FM volunteer male cigarette smokers, (addicted overnight-tobacco-abstinent) each smoked 4 filter cigarettes, one half-hourly over 2 hours, either or according to usual habit, using the CReSSMicro flowmeter. First was own brand. Subsequent all Holiday regular...
Cite this as: K. Wickens, R. Beasley, I. Town, M. Epton, P. Pattemore, T. Ingham, J. Crane and the New Zealand Asthma Allergy Cohort Study Group, Clinical & Experimental Allergy, 2011 (41) 399–406. Summary Background Despite reports of positive associations between paracetamol asthma, nature these is unclear. Objective We aimed to investigate infant childhood use atopy allergic disease at 5–6 years. Methods In a birth cohort study, we collected reported exposure 15 months in Christchurch...
Abstract Background Epidemiological and family studies suggest that lung cancer results from the combined effects of age, smoking genetic factors. Chronic obstructive pulmonary disease (COPD) is also an independent risk factor for coexists in 40–60% cases. Methods In a two-stage case–control association study, markers associated with either susceptibility or protection against were identified. test cohort 439 Caucasian smokers ex-smokers, consisting healthy cases, 157 candidate single...