A5013336903- Osteoarthritis Treatment and Mechanisms
- Tendon Structure and Treatment
- Shoulder Injury and Treatment
- COVID-19 Clinical Research Studies
- Mosquito-borne diseases and control
- Malaria Research and Control
- Inflammatory mediators and NSAID effects
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Chronic Disease Management Strategies
- Peroxisome Proliferator-Activated Receptors
- Bone and Dental Protein Studies
- Proteoglycans and glycosaminoglycans research
- Laser Applications in Dentistry and Medicine
- Health disparities and outcomes
- Intensive Care Unit Cognitive Disorders
- Privacy-Preserving Technologies in Data
- Prostate Cancer Treatment and Research
- Fatty Acid Research and Health
- Emergency and Acute Care Studies
- Collagen: Extraction and Characterization
- Veterinary Equine Medical Research
- Homelessness and Social Issues
- Data Quality and Management
- Enzyme Production and Characterization
Swansea University
2011-2025
Innovative Vector Control Consortium
2018-2024
NHS Digital
2024
Hywel Dda University Health Board
2024
Liverpool School of Tropical Medicine
2018-2023
NIHR Clinical Research Network
2021
Nepal Health Research Council
2021
National Institute for Health Research
2021
National Records of Scotland
2021
Intensive Care National Audit & Research Centre
2021
In the context of stalling progress against malaria, resistance mosquitoes to insecticides, and residual transmission, mass drug administration (MDA) ivermectin, an endectocide used for neglected tropical diseases (NTDs), has emerged as a promising complementary vector control method. Ivermectin reduces life span
Abstract Objective To determine if n‐3 polyunsaturated fatty acid (PUFA) supplementation (versus treatment with n‐6 or other supplements) affects the metabolism of osteoarthritic (OA) cartilage. Methods The metabolic profile human OA cartilage was determined at time harvest and after 24‐hour exposure to PUFAs classes acids, followed by explant culture for 4 days in presence absence interleukin‐1 (IL‐1). Parameters measured were glycosaminoglycan release, aggrecanase matrix metalloproteinase...
We have examined the catabolism of proteoglycans aggrecan, decorin and biglycan in fresh tendon samples explant cultures tissue from tensional compressed regions young mature bovine tendons. A panel well-characterized antibodies that recognize glycosaminoglycan or protein (linear neoepitope) sequences was used to detect proteoglycan degradation products were both retained within released into culture medium. In addition, a reverse-transcriptase-mediated PCR analysis examine mRNA expression...
Substantial research is underway to develop next-generation interventions that address current malaria control challenges. As there limited testing in their early development, it difficult predefine intervention properties such as efficacy achieve target health goals, and therefore challenging prioritize selection of novel candidate interventions. Here, we present a quantitative approach guide development using mathematical models dynamics coupled with machine learning. Our analysis...
The mouse intestinal epithelium represents a unique mammalian system for examining the relationship between cell division, commitment, and differentiation. Proliferation differentiation are rapid, perpetual, spatially well-organized processes that occur along crypt-to-villus axis involve clearly defined lineages derived from common multipotent stem located near base of each crypt. Nucleotides -1178 to +28 rat fatty acid binding protein gene were used establish three pedigrees transgenic mice...
The Welsh Index of Multiple Deprivation (WIMD) is an area-based deprivation measure comprising eight domains, produced by the Government to rank Lower Layer Super Output Areas (LSOAs) in Wales. Researchers use WIMD account for deprivation, however, as one domain contains health indicators, there a risk endogeneity bias when using research on outcomes. This study evaluated effect results removing from overall or only income measures. 2019 scores were linked 2,760,731 individuals SAIL...
This study describes the interaction of a small chondroitin sulphate proteoglycan and glycosaminoglycans 4‐sulphate, dermatan heparan with hydroxyapatite. All macromolecules possessed high affinity, iduronic acid‐rich displaying higher adsorption maxima than glucuronic 4‐sulphate. At similar concentrations, produced 30% inhibition hydroxyapatite‐induced crystal growth, whilst 4‐sulphate yielded 50% inhibition. Estimation calcium binding capacity these using equilibrium dialysis indicated...
Introduction: Mental disorder (MD) and substance use (SUD) are associated with poorer than average health greater mortality. We analysed routine primary care (WLGP) inpatient admission (PEDW) data to estimate incidence of co-occurring (CC) MD SUD, all-cause mortality survival CC, in children young people Wales, UK. Methods: A retrospective population-based electronic cohort study using from the Secure Anonymised Information Linkage (SAIL) Databank. Participants were 958,603 individuals aged...
AbstractReactive oxygen species (ROS) are being increasingly implicated in the connective tissue degradation associated with chronic inflammatory conditions, such as periodontal disease. The present study investigated effects of ROS on proteoglycans (PG) alveolar bone which important structural components within periodontium. PG were isolated from ovine and exposed to increasing concentrations hydrogen peroxide (H2O2) or a hydroxyl radical (*OH) flux for lh 24h, products examined...
Cyclooxygenase-2 (COX-2) is intimately involved in symptoms of arthritis while dietary n-3 polyunsaturated fatty acids (PUFA) are thought to be beneficial. In these experiments, using both bovine and human vitro systems that mimic features arthritis, we show the PUFA eicosapentaenoic acid (EPA) able reduce mRNA protein levels COX-2. Activity, as assessed through prostaglandin E(2) formation, was also reduced a dose-dependent manner. These effects EPA contrasted noticeably with n-6 PUFA,...
Background Graduate entry medicine raises new questions about the suitability of students with different backgrounds. We examine this, and broader issue effectiveness selection assessment procedures. Methods The data included background characteristics, academic record, interview score performance in pre-clinical modular for two years intake graduate medical students. Exploratory factor analysis is a powerful method reducing large number measures to smaller group underlying factors. It was...
We have examined the catabolism of proteoglycans aggrecan, decorin and biglycan in fresh tendon samples explant cultures tissue from tensional compressed regions young mature bovine tendons. A panel well-characterized antibodies that recognize glycosaminoglycan or protein (linear neoepitope) sequences was used to detect proteoglycan degradation products were both retained within released into culture medium. In addition, a reverse-transcriptase-mediated PCR analysis examine mRNA expression...
Abstract Insecticides are widely used to control the insects that spread human infectious diseases, in particular falciparum malaria. This widespread use has driven insecticide resistance (IR) high levels may threaten effectiveness of future programmes. There is interest identifying deployment methods alleviate pressures driving IR and we investigate three. Mixtures are, as already known, highly effective slowing providing their (ability kill fully sensitive insects) remain close 100%. be...