A5091446400- Intracranial Aneurysms: Treatment and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroinflammation and Neurodegeneration Mechanisms
- Autophagy in Disease and Therapy
- Mitochondrial Function and Pathology
- Genetic and phenotypic traits in livestock
- Nanoplatforms for cancer theranostics
- Graphene and Nanomaterials Applications
- Adenosine and Purinergic Signaling
- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- Cancer, Hypoxia, and Metabolism
- Cerebrovascular and Carotid Artery Diseases
- Immune Cell Function and Interaction
- Liver Disease Diagnosis and Treatment
- S100 Proteins and Annexins
- Esophageal Cancer Research and Treatment
- Metabolism, Diabetes, and Cancer
- Cancer-related molecular mechanisms research
- Diet, Metabolism, and Disease
- Bone and Dental Protein Studies
- Lung Cancer Diagnosis and Treatment
- Nanoparticle-Based Drug Delivery
- Copper-based nanomaterials and applications
Capital Medical University
2020-2025
Jiangsu Province Hospital
2017-2025
Nanjing Medical University
2017-2025
Fudan University
2021-2025
Harbin Medical University
2017-2025
First Affiliated Hospital of Harbin Medical University
2017-2025
Tianjin University of Traditional Chinese Medicine
2023-2025
Sichuan University
2025
Loma Linda University
2018-2024
State Key Laboratory of Medical Neurobiology
2021-2024
Reperfusion injury is still a major challenge that impedes neuronal survival in ischemic stroke. However, the current clinical treatments are remained on single pathological process, which due to lack of comprehensive neuroprotective effects. Herein, macrophage-disguised honeycomb manganese dioxide (MnO2 ) nanosphere loaded with fingolimod (FTY) developed salvage penumbra. In particular, biomimetic nanoparticles can accumulate actively damaged brain via macrophage-membrane protein-mediated...
Abstract Current therapeutic strategies for Alzheimer's disease (AD) treatments mainly focus on β‐amyloid (Aβ) targeting. However, such have limited clinical outcomes due to the chronic and irreversible impairment of nervous system in late stage AD. Recently, inflammatory responses, manifested oxidative stress glial cell activation, been reported as hallmarks early stages Based crosstalk between response brain cells, a reactive oxygen species (ROS)‐responsive dendrimer–peptide conjugate...
Background and Purpose— Mitoquinone has been reported as a mitochondria-targeting antioxidant to promote mitophagy in various chronic diseases. Here, our aim was study the role of mitoquinone activation oxidative stress–induced neuronal death reduction after subarachnoid hemorrhage (SAH) rats. Methods— Endovascular perforation used for SAH model male Sprague-Dawley Exogenous injected intraperitoneally 1 hour SAH. ML385, an inhibitor Nrf2 (nuclear factor-E2-related factor 2), given...
Oxidative stress and neuronal apoptosis have been demonstrated to be key features in early brain injury (EBI) after subarachnoid hemorrhage (SAH). Previous studies indicated that Mas receptor activation initiates an anti-oxidative anti-apoptotic role the brain. However, whether can attenuate oxidative SAH remains unknown. To investigate beneficial effect of on induced by SAH, a total 196 rats were subjected endovascular perforation model SAH. AVE 0991 (AVE), selective agonist Mas, was...
Neuroinflammation and blood-brain barrier (BBB) disruption are two critical mechanisms of subarachnoid hemorrhage (SAH)-induced brain injury, which closely related to patient prognosis. Recently, angiogenic factor with G-patch FHA domain 1 (Aggf1) was shown inhibit inflammatory effect preserve vascular integrity in non-nervous system diseases. This study aimed determine whether Aggf1 could attenuate neuroinflammation BBB after experimental SAH, as well the underlying its protective roles.Two...
White matter injury (WMI) is associated with motor deficits and cognitive dysfunctions in subarachnoid hemorrhage (SAH) patients. Therapeutic strategy targeting WMI would likely improve the neurological outcomes after SAH. Low-density lipoprotein receptor-related protein-1 (LRP1), a scavenger receptor of apolipoprotein E (apoE), able to modulate microglia polarization towards anti-inflammatory M2 phenotypes during inflammatory oxidative insult. In present study, we investigated effects LRP1...
Metabolic interactions between different cell types in the tumor microenvironment (TME) often result reprogramming of metabolism to be totally from their normal physiological processes order support growth. Many studies have attempted inhibit growth and activate immunity by regulating tumors other cells TME. However, metabolic inhibitors suffer heterogeneity tumors, since favorable regulation malignant TME is inconsistent with each other. Therefore, we reported design a pH-sensitive drug...
Neonatal heart undergoes metabolic conversion and cell cycle arrest preparing for the increased workload during adulthood. Herein, we report that neonatal ketone body elevation is a critical regulatory factor postnatal development. Through multiomics screening, found expression of 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2), rate-limiting enzyme ketogenesis, was transiently induced by colostrum in heart. Hmgcs2 knockout caused mitochondrial maturation defects. Meanwhile, development...
The liver lipid metabolism of older individuals canbecome impaired and the circadian rhythm genes involved in is also disturbed. Although link between rhythms already recognized, how these processes are decoupled during aging still largely unknown. Here, we show that for transcription factor Egr-1 expression shifted forward with age male mice. deletion accelerates age-related metabolic dysfunction, which associates increased triglyceride accumulation, disruption opposite rhythmic coupling...
Reperfusion injury presents a significant obstacle to neuronal survival following successful recanalization in ischemic stroke, which is characterized by intricate pathophysiological processes comprising numerous interconnected pathways. Oxidative stress-induced ferroptosis and the overactivation of glial cells play important roles this phenomenon. In study, we developed targeted cross-linked micelle loaded with idebenone rescue penumbra inhibiting overactivation. rat models, CREKA...
Abstract Fat‐tailed sheep have a unique characteristic of depositing fat in their tails. In the present study, we conducted genome‐wide association studies (GWAS) on traits related to tail deposition and body size Hulun Buir sheep. A total number 300 individuals belonging two fat‐tailed lines breed genotyped with Ovine Infinium HD SNP BeadChip were included current study. Two mixed models, one for continuous binary phenotypic traits, employed analyse ten that is, length (BL), height (BH),...
Rationale: Antiretroviral therapy can effectively suppress HIV-1 replication in the peripheral blood to an undetectable level. However, elimination of latent virus reservoirs remains a challenge and is major obstacle treatment HIV-1-infected patients. Exosomes exhibit huge promise as endogenous drug delivery nanosystem for delivering drugs solid tissues given their unique properties, including low immunogenicity, innate stability, high efficiency, most importantly ability penetrate due...
Microplastics and nanoplastics (MPs/NPs) are posing emerging potential threats to global ecosystems human health. Recently, the individual effects of MPs/NPs combined MPs/NPs-coexisting pollutants on soil–terrestrial plant systems have attracted increasing attention. Based latest research progress, this review firstly summarized sources interaction between coexisting in soil environment, then systematically induced their multilevel impacts properties terrestrial plants. Soil agroecosystem...
Abstract Background With the development and popularization of low-dose chest CT technology, diagnosis survival rates patients with early lung cancer (LC) have significantly improved. The occurrence colorectal (CRC) as second primary (SPC) in (PLC) survivors has become an essential factor affecting prognosis LC. This study explored potential association between PLC CRC genetically, laying a foundation for developing SPC-CRC prevention strategies after Methods Based on two-sample...
Background Glibenclamide has garnered attention due to its multifaceted neuroprotective effects in cases of acute central nervous system injury. We initiated a trial explore the effectiveness and safety high dose glibenclamide management cerebral oedema following aneurysmal subarachnoid haemorrhage (aSAH). Methods This constituted single-centre, randomised clinical study. Half 56 patients assigned group received 15 mg tablets daily for 10 days (5 mg, three times/day). The primary outcome was...